Physician
Hematology
Dr. Steven M. Lipkin, MD
Steven Lipkin works in the field of Hematology. He graduated from University of California San Diego School of Medicine. University of California San Diego School of Medicine has a rank of 17 in research and a 19 in primary care He received awards:"CMS Meaningful Use Stage 1 Certification". Dr. Steven M. Lipkin has written publications. He has 58 publications published with PubMed. The lastest paper is: 'Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leu...'
Publications
- A Phase IIa Randomized, Double-Blind Trial of Erlotinib in Inhibiting Epidermal Growth Factor Receptor Signaling in Aberrant Crypt Foci of the Colorectum.
- A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
- Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant.
- Unbiased Metabolite Profiling Indicates that a Diminished Thymidine Pool Is the Underlying Mechanism of Colon Cancer Chemoprevention by Alpha-Difluoromethylornithine.
- Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the "Guilt-by-Association" Principle.
- Asymmetric division: a marker for cancer stem cells in early stage tumors?
- A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells.
- Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.
- Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.
- The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.
- miR-23a Promotes the Transition from Indolent to Invasive Colorectal Cancer.
- Three-dimensional reconstruction of protein networks provides insight into human genetic disease.
- Frequency Domain Analysis Reveals External Periodic Fluctuations Can Generate Sustained p53 Oscillation.
- The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.
- Clinical genetics of hereditary colorectal cancer.
- A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.
- Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
- Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.
- NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer.
- Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
- Survival of distinct Asian groups among colorectal cancer cases in California.
- A population-based, descriptive analysis of malignant intraductal papillary mucinous neoplasms of the pancreas.
- Effects of socioeconomic status and treatment disparities in colorectal cancer survival.
- Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).
- Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
- Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
- Familial colorectal cancer syndrome X.
- Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California.
- Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair.
- Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
- What are SNPs and haplotypes and how will they help us manage the prevention of adult cancer?
- Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
- CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.
- The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
- Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor.
- Meiotic arrest and aneuploidy in MLH3-deficient mice.
- Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer.
- Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
- Use of dermagraft, a cultured human dermis, to treat diabetic foot ulcers.
- Mouse models of inherited cancer syndromes.
- Pharmacogenomics of colorectal cancer prevention and treatment.
- Phase IIA trial testing erlotinib as an intervention against intraductal pancreatic mucinous neoplasms.
- Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.
- The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.
- Regulation of gene expression by thyroid hormones and retinoic acid.
- A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains.
- A nonsense mutation in MLH1 causes exon skipping in three unrelated HNPCC families.
- Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers.
- MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
- Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leu...
- Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients.
- A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.
- Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.
- Kinetics of cancer: a method to test hypotheses of genetic causation.
- Genetic testing to identify high-risk populations for chemoprevention studies.
- Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer.
- A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.
Doctors Specialties
- Clinical Genetics
- Internal Medicine
- Hematology
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Cigna HMO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Empire Blue Cross Blue Shield HMO
- Pathway Enhanced Guided Access
- Prism Blue Priority EPO
- Medicare MCR
- Freedom Plan
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
Awards
- CMS Meaningful Use Stage 1 Certification
Education
-
National Institutes of Health Clinical Center -
Duke University Hospital -
University of California San Diego School of Medicine
Hospital
-
NewYork-Presbyterian/Weill Cornell -
UC Irvine Medical Center
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