Professor, Medicine, Perelman School of Medicine
Pulmonology
Dr. Steven M. Albelda, MD
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Steven Albelda is an expert in the field of Pulmonology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He received 1 awards: "Elected Member". Dr. Steven M. Albelda is a published doctor and has 99 publications published. The lastest was: 'PILOT AND FEASIBILITY TRIAL OF IMMUNO-GENE THERAPY OF MALIGNANT MESOTHELIOMA USING INTRAPLEURAL DELIVERY OF ADENOVIRUS- INTERFERON-ALPHA COMBINED WITH CHEMOTHERAPY.' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- PILOT AND FEASIBILITY TRIAL OF IMMUNO-GENE THERAPY OF MALIGNANT MESOTHELIOMA USING INTRAPleural DELIVERY OF ADENOVIRUS- INTERFERON-ALPHA COMBINED WITH CHEMOTHERAPY.
- Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.
- An optimized disaggregation method for human Lung tumors that preserves the phenotype and function of the immune cells.
- Intraoperative near-infrared imaging can identify Pulmonary nodules.
- Multifactorial T cell Hypofunction That is Reversible Can Limit the Efficacy of Chimeric Antibody Receptor-transduced Human T cells in Solid Tumors.
- Mesothelin-specific Chimeric Antigen Receptor mRNA-Engineered T cells Induce Anti-Tumor Activity in Solid Malignancies.
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity.
- Giving Oncolytic Vaccinia Virus More BiTE.
- Modifying tumor-associated macrophages: An important adjunct to immunotherapy.
- Use of Circulating Tumor Cell Technology (CELLSEARCH®) for the Diagnosis of Malignant Pleural Effusions.
- Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road.
- Inhibition of p300 impairs Foxp3(+) T regulatory cell function and promotes antitumor immunity.
- Immunological effects of the TGFβ-blocking antibody GC1008 in malignant Pleural mesothelioma patients.
- T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
- Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.
- Thymidylate Synthase and Folyl-Polyglutamate Synthase Are Not Clinically Useful Markers of Response to Pemetrexed in Patients with Malignant Pleural Mesothelioma.
- Using macrophage activation to augment immunotherapy of established tumours.
- The receptor for advanced glycation end products mediates Lung endothelial activation by RBCs.
- The Rac1 splice form Rac1b promotes K-ras-induced Lung tumorigenesis.
- Changes in the local tumor microenvironment in recurrent Cancers may explain the failure of vaccines after surgery.
- Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM).
- Peripheral immune cell gene expression predicts survival of patients with non-small cell Lung cancer.
- Mesothelin, a novel immunotherapy target for triple negative breast Cancer.
- Gene therapy for Lung neoplasms.
- Treating Tumors With a Vaccinia Virus Expressing IFN? Illustrates the Complex Relationships Between Oncolytic Ability and Immunogenicity.
- Lower serum endocan levels are associated with the development of acute Lung injury after major trauma.
- Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced Lung cancer by loss of the TGF-{be...
- Targeted Endothelial Delivery of Nanosized Catalase Immunoconjugates Protects Lung Grafts Donated After Cardiac Death.
- Resection of non-small cell Lung cancers reverses tumor-induced gene expression changes in the peripheral immune system.
- Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation.
- The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
- A trial of intraPleural adenoviral-mediated Interferon-?2b gene transfer for malignant Pleural mesothelioma.
- Gene therapy for mesothelioma.
- Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma.
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Eradication by Human T Cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor.
- Monocyte chemoattractant protein-1 blockade inhibits Lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells.
- ANGPT2 Genetic Variant is Associated with Trauma-Associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio.
- Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections.
- Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor.
- Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycat...
- Chemotherapy delivered after viral immunogene therapy augments antitumor efficacy via multiple immune-mediated mechanisms.
- Activation of the nucleotide oligomerization domain signaling pathway by the non-bacterially derived xanthone drug 5'6-dimethylxanthenone-4-acetic acid (Vadimezan).
- A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and Metastatic pleural effusions.
- Gene therapy for mesothelioma and Lung cancer.
- Urinary volatile compounds as biomarkers for Lung cancer: a proof of principle study using odor signatures in mouse models of Lung cancer.
- CCL2 blockade augments Cancer immunotherapy.
- Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-beta for use in malignant Pleural mesothelioma: heterogeneity in interferon respons...
- Targeted detoxification of selected reactive oxygen species in the vascular endothelium.
- Expression of IFN-beta enhances both efficacy and safety of oncolytic vesicular stomatitis virus for therapy of mesothelioma.
- Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.
- Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced Lung thrombosis and inflammation.
- The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and Lung cancer cells in vitro and in vivo with particular efficacy for small cell Lung cancer.
- Kinetics of soluble mesothelin in patients with malignant Pleural mesothelioma during treatment.
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.
- Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy.
- Variation in the myosin light chain kinase gene is associated with development of acute Lung injury after major trauma.
- Variation in the MYLK gene is associated with development of acute Lung injury after major trauma.
- Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid Cancers.
- B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models.
- Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the Pulmonary vasculature.
- Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.
- Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intr...
- A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and Metastatic pleural effusions: high rate of antitumor...
- The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.
- Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response.
- Gemcitabine has significant immunomodulatory activity in murine tumor models independent of its cytotoxic effects.
- A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and Lung squamous cell carcinoma.
- Cytokine gene therapy for malignant Pleural mesothelioma.
- A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor ...
- Dissociation between alveolar transmigration of neutrophils and Lung injury in hyperoxia.
- Blockade of TNF-alpha decreases both inflammation and efficacy of intraPulmonary Ad.IFNbeta immunotherapy in an orthotopic model of bronchogenic lung cancer.
- Cycloxygenase-2 inhibition augments the efficacy of a Cancer vaccine.
- Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysi...
- Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor im...
- Long-term follow-up of patients with malignant Pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy.
- Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity.
- IntraPulmonary IFN-beta gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung.
- Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell Lung cancer: a review.
- Regulatory T cells and cytokines in malignant Pleural effusions secondary to mesothelioma and carcinoma.
- Treatment of Lung cancer using clinically relevant oral doses of the cyclooxygenase-2 inhibitor rofecoxib: potential value as adjuvant therapy after surgery.
- Soluble type II transforming growth factor-beta receptor inhibits established murine malignant mesothelioma tumor growth by augmenting host antitumor immunity.
- Role of lateral cell-cell border location and extracellular/transmembrane domains in PECAM/CD31 mechanosensation.
- Role for platelet-endothelial cell adhesion molecule-1 in macrophage Fcgamma receptor function.
- TNFerade to the rescue? Guidelines for evaluating phase I Cancer gene transfer trials.
- Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.
- Use of cyclooxygenase-2 inhibition to enhance the efficacy of immunotherapy.
- Differentially expressed apoptotic genes in early stage Lung adenocarcinoma predicted by expression profiling.
- PECAM-directed delivery of catalase to endothelium protects against Pulmonary vascular oxidative stress.
- Gene expression profiling of malignant mesothelioma.
- PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis.
- Microarray data simulator for improved selection of differentially expressed genes.
- Gene expression profiling of the early Pulmonary response to hyperoxia in mice.
- ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface.
- Alterations in cell cycle genes in early stage Lung adenocarcinoma identified by expression profiling.
- PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.
- Immunotargeting of catalase to the Pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury.
- Platelet endothelial cell adhesion molecule-1 in neutrophil emigration during acute bacterial Pneumonia in mice and rats.
- BRAF and RAS mutations in human Lung cancer and melanoma.
Schools
Perelman School of Medicine University of Pennsylvania
Hospital Of The University Of Pennsylvania
Procedures Preformed
- Bronchoscopy
- Thoracentesis
- Ventilation Management
Conditions Treated
- Acidosis
- Asthma
- Bronchiectasis
- Bronchiolitis
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Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Blue Card PPO
- Great West Healthcare-Cigna PPO
- Commercial Insurance Company
- Coventry Health America PPO
- First Health (Coventry Health Care) PPO
- Geisinger Health Plan
- HealthPartners
- Community Blue PPO
- Direct Access
- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
- Horizon Blue Cross Blue Shield PPO
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicaid
- Medicare MCR
- MultiPlan PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- Elected Member
Education
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University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Hospital of the University of Pennsylvania
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1730111733 |
| Last Name Of The Provider | ALBELDA |
| First Name Of The Provider | STEVEN |
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