Professor, Medicine and Pediatrics, Sidney Kimmel Medical College-Thos Jefferson Univ
Hematology
Dr. Steven E. McKenzie, MD
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Steven E. McKenzie, MD practices Hematology. He went to Perelman School of Medicine at the University of Pennsylvania. He has 1 awards "CMS Meaningful Use Stage 1 Certification". Steven McKenzie is a published MD. He published 67 publications, including: 'System for preparing microhybridization arrays on glass slides.'
Publications
- Anti-miR-148a regulates Platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.
- Platelet transactivation by monocytes promotes the prothrombotic State in heparin-induced thrombocytopenia.
- Analysis of 13 Cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs.
- Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia.
- Human Platelet microRNA-mRNA networks associated with age and gender revealed by integrated Plateletomics.
- Identification of a developmental gene expression signature, including HOX genes, for the normal human colonic crypt stem cell niche - Overexpression of the signature ...
- MicroRNAs in Platelet production and activation.
- Cooperative integrin/ITAM signaling in Platelets enhances thrombus formation in vitro and in vivo.
- Erythropoietin levels in patients with Sickle cell disease do not correlate with known inducers of erythropoietin.
- MicroRNA Expression Differences in Human Hematopoietic Cell Lineages Enable Regulated Transgene Expression.
- The human Platelet: strong transcriptome correlations among individuals associate weakly with the Platelet proteome.
- Identification of an altered immunoglobulin heavy-chain gene rearrangement in the central nervous system in B-precursor acute lymphoblastic leukemia.
- Enhancement in vitro of the low interferon-gamma production of leukocytes from human newborn infants.
- Bilateral microtia and cleft palate in cousins with Diamond-Blackfan Anemia.
- Effect of gamma interferon on expression of Fc gamma receptors in monocytes of newborn infants and adults.
- Nucleic acid detection using non-radioactive labelling methods.
- The biophysics of DNA hybridization with immobilized oligonucleotide probes.
- Humanized mouse models of FcR clearance in immune platelet Disorders.
- Human Fc gamma RII: the structure of the Fc gamma RII cytosolic domain governs phagocytic function.
- Generation of patterns from gene expression data by assigning confidence to differentially expressed genes.
- Variation in human FCGR2C gene copy number.
- Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism.
- GATA and NF-Y participate in transcriptional regulation of FcgammaRIIA in megakaryocytic Cells.
- System for preparing microhybridization arrays on glass slides.
- Parallel molecular genetic analysis.
- Fluorescence-based RT PCR analysis: determination of the ratio of soluble to membrane-bound forms of Fc gamma RIIA transcripts in hematopoietic Cell lines.
- Fc gamma receptors in phagocytes.
- Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED).
- Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function.
- Characterization of the 5''-flanking transcriptional regulatory region of the human Fc gamma receptor gene, Fc gamma RIIA.
- Relationship between Fc receptor IIA polymorphism and infection in children with Sickle cell disease.
- Lineage-specific alternative splicing of the human Fc gamma RIIA transmembrane exon requires sequences near the 3' splice site.
- Differential expression of Fc gamma RIIA, Fc gamma RIIB and Fc gamma RIIC in hematopoietic Cells: analysis of transcripts.
- -245 bp of 5'-flanking region from the human Platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo.
- A soluble form of the human Fc receptor Fc gamma RIIA: cloning, transcript analysis and detection.
- Biological advances and clinical applications of Fc receptors for IgG.
- Human c-kit ligand (stem cell factor) induces Platelet Fc receptor expression in megakaryoblastic cells.
- Localization of distal regulatory domains in the megakaryocyte-specific Platelet basic protein/Platelet factor 4 gene locus.
- Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).
- Thrombosis and shock induced by activating antiPlatelet antibodies in human Fc gamma RIIA transgenic mice: the interplay among antibody, spleen, and Fc receptor.
- Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model.
- A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor.
- Thrombopoietin in preterm infants: gestational age-dependent response.
- The role of the human Fc receptor Fc gamma RIIA in the Immune clearance of platelets: a transgenic mouse model.
- Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/Platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopen...
- Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human Platelet factor 4 and Platelet activation through FcgammaRIIA.
- CalDAG-GEFI deficiency protects mice in a novel model of Fc? RIIA-mediated thrombosis and thrombocytopenia.
- PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.
- Amelioration of murine Immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP?
- Dominant expression of the inhibitory FcgammaRIIB prevents antigen presentation by murine plasmacytoid dendritic Cells.
- The clot thickens (or not).
- Thrombopoietin following transfusion of Platelets in preterm neonates.
- Heparin-induced thrombocytopenia: an autoImmune disorder regulated through dynamic autoantigen assembly/disassembly.
- Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive micro...
- Platelet FcgammaRIIA binds and internalizes IgG-containing complexes.
- Development of spontaneous multisystem autoImmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice.
- A novel human CD32 mAb blocks experimental Immune haemolytic anaemia in FcgammaRIIA transgenic mice.
- PF4/heparin complexes are T Cell-dependent antigens.
- Heparin-induced thrombocytopenia and other Immune thrombocytopenias: lessons from mouse models.
- Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.
- Short-term use of umbilical artery catheters may not be associated with increased risk for thrombosis.
- Mechanisms of action of therapeutics in idiopathic Thrombocytopenic purpura.
- Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response?
- Mechanisms of action of IVIg: physiology of Fc receptors.
- Insights from mouse models of heparin-induced thrombocytopenia and thrombosis.
- Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential.
Schools
Perelman School of Medicine University of Pennsylvania
Children39s Hospital Philadelphia
Conditions Treated
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Hypercoagulable State
- Immune Thrombocytopenic Purpura (ITP)
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Doctors Specialties
- Hematology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Children's Hospital of Philadelphia -
University of Pennsylvania -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Thomas Jefferson University Hospital
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