Professor, Pediatrics, University of Texas Southwestern Medical Center, Southwestern Medical School
Pediatric Hematology & Oncology
Dr. Stephen X. Skapek, MD
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Stephen X. Skapek, MD works in the field of Pediatric Hematology & Oncology. He studied medicine at Duke University School of Medicine. Duke University School of Medicine is a top medical college. Duke University School of Medicine has a rank of 8 in research and a 29 in primary care Stephen Skapek is a published doctor and has 62 publications published. The lastest was: 'Combination chemotherapy using vinblastine and methotrexate for the treatment of progressive desmoid tumor in children.'
Publications
- Clonality and evolutionary history of rhabdomyosarcoma.
- Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database.
- Sarcomas.
- Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children's Oncology Group.
- Myogenin, AP2β, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology...
- Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
- A novel algorithm for simplification of complex gene classifiers in cancer.
- Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's...
- Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma: A report from the children's oncology group.
- A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye.
- PAX-FOXO1 Fusion Status Drives Unfavorable Outcome for Children With Rhabdomyosarcoma: A Children's Oncology Group Report.
- Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: results of a Children's Oncology Group (COG) phase II study.
- The clinical, research, and social value of autopsy after any cancer death: A perspective from the Children's Oncology Group Soft Tissue Sarcoma Committee.
- Retinoic acid fails to induce cell cycle arrest with myogenic differentiation in rhabdomyosarcoma.
- Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group.
- Myogenesis and rhabdomyosarcoma the Jekyll and Hyde of skeletal muscle.
- Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK.
- Childhood rhabdomyosarcoma: new insight on biology and treatment.
- Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature.
- Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development.
- p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor.
- Pediatric nonrhabdomyosarcoma soft tissue sarcomas.
- Prolactinoma as the first manifestation of Gardner's syndrome.
- Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma.
- MRI and biologic behavior of desmoid tumors in children.
- Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature.
- Vinblastine and methotrexate for desmoid fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial.
- Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor.
- Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma.
- Regulation of cell lineage specification by the retinoblastoma tumor suppressor.
- Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells.
- The Arf tumor suppressor regulates platelet-derived growth factor receptor beta signaling: a new view through the eyes of Arf(-/-) mice.
- Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye.
- Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene.
- Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.
- Synovial sarcoma in pediatric patients.
- The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development.
- The proliferative and apoptotic activities of E2F1 in the mouse retina.
- Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development.
- Cytogenetics and the biologic basis of sarcomas.
- Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB.
- Combination chemotherapy using vinblastine and methotrexate for the treatment of progressive desmoid tumor in children.
- Cytogenetics and the biological basis of sarcomas.
- Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia.
- Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation.
- Genes in the RB pathway and their knockout in mice.
- Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase.
- Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.
- Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal.
- Sinusitis and bacteremia caused by Flavobacterium meningosepticum in a sixteen-year-old with Shwachman Diamond syndrome.
- Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine.
- Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts.
- Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.
- Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma.
- Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.
- Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.
- Negative regulation of initial steps in skeletal myogenesis by mTOR and other kinases.
- Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney.
- Isolation and characterization of mammalian cells expressing the Arf promoter during eye development.
- Varied manifestations of persistent hyperplastic primary vitreous with graded somatic mosaic deletion of a single gene.
- Arf Induction by Tgfβ Is Influenced by Sp1 and C/ebpβ in Opposing Directions.
Schools
Duke Univ Sch Of Med
Wilford Hall Med Center Aetc
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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San Antonio Uniformed Services Health Education Consortium -
Duke University School of Medicine
Hospital
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University of Chicago Medical Center -
Children's Health System of Texas -
University of Texas Southwestern Medical Center
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