Professor, Medicine, University of Pittsburgh School of Medicine
Gastroenterology
Dr. Stephen J. O'Keefe, MD
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Stephen J. O'Keefe works in the field of Gastroenterology. He has 3 awards "CMS Meaningful Use Stage 1 Certification", "Fellow (AGAF)" and "Fellow (FACG)". Dr. Stephen J. O'Keefe is a published doctor as well. He has 100 publications published. The latest was: Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF recepto...
Publications
- Diet, microbiota, and dysbiosis: a 'recipe' for Colorectal cancer.
- Jejunal Feeding in Patients With Pancreatitis.
- Study of teduglutide effectiveness in parenteral nutrition-dependent short-Bowel syndrome subjects.
- The Microbiota and Its Metabolites in Colonic Mucosal Health and Cancer Risk.
- Early jejunal feeding initiation and clinical outcomes in patients with severe acute Pancreatitis.
- A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203...
- Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.
- Effect of severe undernutrition and subsequent refeeding on gut mucosal protein fractional synthesis in human subjects.
- Bacterial overgrowth and liver complications in short bowel Intestinal failure patients.
- Short Bowel syndrome: clinical guidelines for nutrition management.
- Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.
- Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
- Targeted therapy of short-Bowel syndrome with teduglutide: the new kid on the block.
- Malnutrition and immuno-incompetence in patients with liver Disease.
- Enteral feeding without pancreatic stimulation.
- Microbial induction of immunity, inflammation, and Cancer.
- Pancreatic enzyme replacement therapy. Importance of Gastric acid secretion, H2-antagonists, and enteric coating.
- Improvement in specificity of [14C]d-xylose breath test for bacterial overgrowth.
- Nutrition in the management of necrotizing Pancreatitis.
- The fat and the thin--a survey of nutritional status and Disease patterns among urbanized Black South Africans.
- The metabolic response and problems with nutritional support in acute tetanus.
- Impact of Malnutrition and its therapy on liver transplantation.
- Effect of fiber supplementation on the microbiota in critically ill patients.
- Efficacy and tolerability of 20 mg pantoprazole versus 300 mg ranitidine in patients with mild reflux-oEsophagitis: a randomized, double-blind, parallel, and multicent...
- Nutritional support for liver transplantation: identifying caloric and protein requirements.
- The plight of modern Bushmen.
- Interventional procedures.
- Products of the colonic microbiota mediate the effects of diet on colon Cancer risk.
- A guide to enteral access procedures and enteral nutrition.
- "Catabolic" Loss of body nitrogen in response to surgery.
- Milk-induced Malabsorption in malnourished African patients.
- Why do African Americans get more colon Cancer than Native Africans?
- Physiological evaluation of the severity of pancreatic exocrine dysfunction during endoscopy.
- Increased plasma tyrosine concentrations in patients with cirrhosis and fulminant hepatic failure associated with increased plasma tyrosine flux and reduced hepatic ox...
- Nutrition in liver failure.
- Comparison of precursor pools with leucine, alpha-ketoisocaproate, and phenylalanine tracers used to measure splanchnic protein synthesis in man.
- Measurement of pancreatic enzyme synthesis in humans. Problems in patients with calcific Pancreatitis.
- Steroids and bowel rest versus elemental diet in the treatment of patients with Crohn's Disease: the effects on protein metabolism and immune function.
- Contribution of elevated protein turnover and anorexia to cachexia in patients with hepatocellular carcinoma.
- Treatment of Intestinal failure: home parenteral nutrition.
- Measurement of gastric and Duodenal mucosal protein turnover in humans.
- The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic Pancreatitis.
- Effect of tramadol and morphine on Pain and gastrointestinal motor function in patients with chronic pancreatitis.
- Severe malnutrition associated with alpha-heavy chain Disease: response to tetracycline and intensive nutritional support.
- Omeprazole and ranitidine in Duodenal ulcer healing.
- Small Bowel intussusception and brown Bowel syndrome in association with severe malnutrition.
- Severe hypophosphataemia in anorexia nervosa.
- Duodenal juice total protein and pancreatic enzyme synthesis, turnover, and secretion in patients after acute pancreatitis.
- Pancreatic enzyme synthesis and turnover in human subjects.
- Short-term effects of an intravenous infusion of a nutrient solution containing amino acids, glucose and insulin on leucine turnover and amino acid metabolism in patie...
- Home parenteral nutrition--a 3-year analysis of clinical and laboratory monitoring.
- Plasma vitamin levels in patients on prolonged total parenteral nutrition.
- Nutrition support in severe acute Pancreatitis.
- Recurrent sepsis in home parenteral nutrition patients: an analysis of risk factors.
- Long-acting somatostatin analogue therapy and protein metabolism in patients with jejunostomies.
- Nutritional support in acute Pancreatitis.
- Trypsin and splanchnic protein turnover during feeding and fasting in human subjects.
- Short bowel syndrome and Intestinal failure: consensus definitions and overview.
- Enteral and parenteral branched chain amino acid-supplemented nutritional support in patients with encephalopathy due to alcoholic liver Disease.
- Feeding the injured pancreas.
- Total enteral nutrition or total parenteral nutrition for prophylaxis of infection in patients with severe acute Pancreatitis?
- Teduglutide for the treatment of short Bowel syndrome.
- Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short Bowel syndrome.
- Nutrition support during acute Pancreatitis.
- Transnasal endoscopic placement of feeding tubes in the intensive care unit.
- Altered bowel function and Duodenal bacterial overgrowth in patients treated with omeprazole.
- Substituted imidazoles as glucagon receptor antagonists.
- Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.
- FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin.
- Effect of chronic Duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroDuodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF recepto...
- Dietary fatty acids modulate chronic Colitis, Colitis-associated colon neoplasia and COX-2 expression in IL-10 knockout mice.
- Hypocaloric jejunal feeding is better than total parenteral nutrition in acute Pancreatitis: results of a randomized comparative study.
- Therapeutic efficacy of Intestinal and multivisceral transplantation: survival and nutrition outcome.
- SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.
- p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.
- A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus.
- Reconstitution of active human calcineurin from recombinant subunits expressed in bacteria.
- L-selectin signaling of neutrophil adhesion and degranulation involves p38 mitogen-activated protein kinase.
- Octreotide as an adjunct to home parenteral nutrition in the management of permanent end-jejunostomy Syndrome.
- Severe acute Pancreatitis: nutritional management in the ICU.
- Trypsin secretion and turnover in patients with acute Pancreatitis.
- Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-[2-(3,4-Bisdifluromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypr...
- Impaired gastric acid and pancreatic enzyme secretion in patients with Crohn's Disease may be a consequenece of a poor nutritional state.
- p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.
- Enteral feeding patients with Gastric outlet obstruction.
- Nutritional immunomodulation of acute Pancreatitis.
- Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway.
- Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors.
- Impaired pancreatic secretion in severely malnourished patients is a consequence of primary pancreatic dysfunction.
- p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.
- A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor.
- Nutrition and quality of life following small Intestinal transplantation.
- Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
- Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.
- The effect of severe undernutrition, and subsequent refeeding on Digestive function in human patients.
- Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
- Pyridazine based inhibitors of p38 MAPK.
- Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex.
- Pyrroles and other heterocycles as inhibitors of p38 kinase.
Schools
Guy39s Hospital Medical School University Of London
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Abdominal Pain
- Anemia
- Benign Neoplasm of the Digestive System
- Cholecystitis and Gallstones
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (AGAF)
- Fellow (FACG)
Education
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Guy's, King's and St Thomas' School of Medical Education
Hospital
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UPMC Presbyterian Shadyside
Drug Facts
| NPI NUMBER | 1366417065 | |
| NPPES Provider LastName | O'KEEFE | |
| NPPES Provider FirstName | STEPHEN | |
| NPPES Provider ZIPCode | 152132546 | |
| NPPES Provider State | PA | |
| Specialty Description | Gastroenterology | |
| Total Claim Count | 101.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1366417065 |
| Last Name Of The Provider | O'KEEFE |
| First Name Of The Provider | STEPHEN |
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