Physician

Pediatric Nephrology

Dr. Stephen I. Alexander, MD

Stephen I. Alexander, MD practices Pediatric Nephrology. Dr. Stephen I. Alexander is a published physician. He has 75 papers published. The most current publication "IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement."

Publications

Sphingosine kinase 1 regulates measles virus replication.
Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future.
IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease.
Approaching the Promise of Operational Tolerance in Clinical Transplantation.
Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus.
Rejection of the kidney allograft.
IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis.
Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression.
Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice.
Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies.
Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubula...
Foxp3 as a marker of tolerance induction versus rejection.
Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells.
Vesicoureteral reflux.
Evaluation and management of steroid-sensitive nephrotic syndrome.
T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice.
Chimerism and tolerance in a recipient of a deceased-donor liver transplant.
Regulatory T cells in renal disease.
TLR4 activation mediates kidney ischemia/reperfusion injury.
Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy.
CD4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease.
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells.
Persistence of naive CD45RA+ regulatory T cells in adult life.
Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin.
DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury.
Multicystic dysplastic kidney and variable phenotype in a family with a novel deletion mutation of PAX2.
DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy.
The role of tubulointerstitial inflammation.
"Pruning" of alloreactive CD4+ T cells using 5- (and 6-)carboxyfluorescein diacetate succinimidyl ester prolongs skin allograft survival.
Human CD62L- memory T cells are less responsive to alloantigen stimulation than CD62L+ naive T cells: potential for adoptive immunotherapy and allodepletion.
DNA vaccination against specific pathogenic TCRs reduces proteinuria in active Heymann nephritis by inducing specific autoantibodies.
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies.
Interferon gamma is required for activation-induced death of T lymphocytes.
Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments.
The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis.
Early cyst growth is associated with the increased nuclear expression of cyclin D1/Rb protein in an autosomal-recessive polycystic kidney disease rat model.
Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura.
CD8 regulatory T cells: what''s old is now new.
Chronic allograft nephropathy.
Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression.
The use of ocular abnormalities to diagnose X-linked Alport syndrome in children.
Chronic allograft nephropathy in paediatric renal transplantation.
Nephrotoxicity with cyclooxygenase 2 inhibitor use in children.
Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia.
T cell receptor BV repertoires using real time PCR: a comparison of SYBR green and a dual-labelled HuTrec fluorescent probe.
Regulatory gamma delta T cells in Heymann nephritis express an invariant Vgamma6/Vdelta1 with a canonical CDR3 sequence.
A novel mutation of WT1 exon 9 in a patient with Denys-Drash syndrome and pyloric stenosis.
Matching T-cell receptors identified in renal biopsies and urine at the time of acute rejection in pediatric renal transplant patients.
Prophylactic bilateral nephrectomies in two paediatric patients with missense mutations in the WT1 gene.
CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection.
NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using...
Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical ...
CCL2 DNA vaccine to treat renal disease.
Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.
Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis.
IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.
Cell-mediated cytotoxicity: a predictor of chronic rejection in pediatric HLA haploidentical renal transplants.
IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement.
Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4(+) T cell alloactivation.
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without...
NK cells do not mediate renal injury in murine adriamycin nephropathy.
A protective role for programmed death 1 in progression of murine adriamycin nephropathy.
Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease.
Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.
Interactions between T lymphocytes and endothelial cells in allograft rejection.
Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro.
Human endothelial cell costimulation of T cell IFN-gamma production.
The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis.
Regulatory immune cells in kidney disease.
Adenovirus associated haematuria.
Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?
Towards a molecular understanding of human diseases using Dictyostelium discoideum.

Doctors Specialties

Pediatric Nephrology

Accepted Insurances

Education

University of Melbourne Faculty of Medicine

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