Professor, Pathology, University of Chicago, Pritzker School of Medicine
Pathology
Dr. Stephen C. Meredith, MD
Stephen Meredith practices Pathology. He attended Washington University School of Medicine in St. Louis. Stephen C. Meredith, MD is a published doctor. He has 75 papers published. The most current publication "Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide."
Publications
- Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.
- Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease.
- Molecular Structure of β-Amyloid Fibrils in Alzheimer's Disease Brain Tissue.
- Relapse or eradication of cancer is predicted by Peptide-major histocompatibility complex affinity.
- The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type A&I...
- The 2.5 å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
- Chaperone-like N-methyl peptide inhibitors of polyglutamine aggregation.
- Protein folding: sticky N17 speeds huntingtin pile-up.
- Novel semisynthetic method for generating full length beta-amyloid peptides.
- Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect.
- Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
- Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure.
- Versatile cyclic templates for assembly of axially oriented ligands.
- The specific amino acid sequence between helices 7 and 8 influences the binding specificity of human apolipoprotein A-I for high density lipoprotein (HDL) subclasses: ...
- Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity.
- Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
- Encapsulation and NMR on an aggregating peptide before fibrillogenesis.
- A mutant chaperone converts a wild-type protein into a tumor-specific antigen.
- Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acids.
- Peptide-based inhibitors of amyloid assembly.
- Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.
- Helix-turn-helix peptides that form alpha-helical fibrils: turn sequences drive fibril structure.
- Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid.
- Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel.
- Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.
- Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
- Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance.
- Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution.
- Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate.
- Fractionation of chylomicrons by heparin-sepharose chromatography. Characterization of two heparin-binding proteins.
- The determination of molecular weight of proteins by gel permeation chromatography in organic solvents.
- Determination of the affinity of vitamin D metabolites to serum vitamin D binding protein using assay employing lipid-coated polystyrene beads.
- Current laser microirradiation studies.
- Identification of the physiologically active state of the mycobacterial glycolipid trehalose 6,6'-dimycolate and the role of fibrinogen in the biologic activities of t...
- A method for probing the affinity of peptides for amphiphilic surfaces.
- Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.
- Characterization of the binding sites for dicarboxylic acids on bovine serum albumin.
- The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B.
- Binding of straight-chain saturated dicarboxylic acids to albumin.
- Deconvolution of gel filtration chromatographs of human plasma lipoproteins.
- Quantitation of aspartate and glutamate in HPLC analysis of phenylthiocarbamyl amino acids.
- Osmotic homeostasis in Dictyostelium discoideum: excretion of amino acids and ingested solutes.
- The role of surface in the biological activities of trehalose 6,6'-dimycolate. Surface properties and development of a model system.
- Mapping the major interaction between binding protein and Ig light chains to sites within the variable domain.
- Physical and surface properties of insect apolipophorin III.
- Ligand-induced conformational change of lipoprotein(a).
- Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered.
- Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.
- Review: model peptides and the physicochemical approach to beta-amyloids.
- Primary structure of guinea pig apolipoprotein E.
- Isolation of an active-site peptide of lipoprotein lipase from bovine milk and determination of its amino acid sequence.
- Tumor cells induce cytolytic T cells to a single immunodominant mutant peptide.
- Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
- Pharmacokinetic differences between a T cell-tolerizing and a T cell-activating peptide.
- Dipolar recoupling NMR of biomolecular self-assemblies: determining inter- and intrastrand distances in fibrilized Alzheimer's beta-amyloid peptide.
- Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.
- Specificity of ligand-induced conformational change of lipoprotein(a).
- Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation.
- The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.
- Conformationally specific enhancement of receptor-mediated LDL binding and internalization by peptide models of a conserved anionic N-terminal domain of human apolipop...
- Familial British dementia: expression and metabolism of BRI.
- Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis.
- Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein.
- A designed Zn2+-binding amphiphilic polypeptide: energetic consequences of pi-helicity.
- Peptide model of a highly conserved, N-terminal domain of apolipoprotein E is able to modulate lipoprotein binding to a member of the class A scavenger receptor family.
- A unique tumor antigen produced by a single amino acid substitution.
- Structure-function relationships in side chain lactam cross-linked peptide models of a conserved N-terminal domain of apolipoprotein E.
- Two-dimensional structure of beta-amyloid(10-35) fibrils.
- Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register.
- Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate...
- Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
- High-resolution structure of a self-assembly-competent form of a hydrophobic peptide captured in a soluble beta-sheet scaffold.
- Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure.
- ?? T cell receptors recognize the nonclassical Major Histocompatibility Complex (MHC) molecule T22 via conserved anchor residues in a MHC-peptide-like fashion.
Schools
Washington University In St Louis School Of Medicine
University Of Chicago Hosps
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
-
University of Chicago -
Washington University School of Medicine in St. Louis
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