Professor, Pediatrics, UCSD School of Medicine
Pediatric Infectious Disease
Dr. Stephen A. Spector, MD
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Stephen A. Spector, MD is an expert in the field of Pediatric Infectious Disease. He graduated from Tufts University School of Medicine. Tufts University School of Medicine is ranked 49/52 in Research/PrimaryCare. He received 2 awards: "Honored" and "Fellow (FAAP)". Stephen Spector has written publications. He has 83 publications published with PubMed. The lastest publication is: 'Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.'
Publications
- Pharmacokinetics and 48-Week Safety and Efficacy of Raltegravir for Oral Suspension in Human Immunodeficiency Virus Type-1-Infected Children 4 Weeks to 2 Years of Age.
- Single high-dose vitamin D at birth corrects vitamin D deficiency in infants in Mexico.
- Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1.
- IL-23 Produced by Myeloid Dendritic Cells Contributes to T-Cell Dysfunction in HIV-1 Infection by Inducing SOCS1 Expression.
- Raltegravir Pharmacokinetics in Neonates Following Maternal Dosing.
- In-Country Migration and Risk Factors for HIV Acquisition among Pregnant Women in Tijuana, Mexico.
- Associations of Host Genetic Variants on CD4+ Lymphocyte Count and Plasma HIV-1 RNA in Antiretroviral Naïve Children.
- Trends in Hospitalizations among Children and Young Adults with Perinatally Acquired HIV.
- Immunogenicity of Licensed Influenza A (H1N1) 2009 Monovalent Vaccines in HIV-Infected Children and Youth.
- Vitamin D-related host genetic variants alter HIV disease progression in children.
- Pharmacokinetics, Safety and 48 Week Efficacy of Oral Raltegravir in Human Immunodeficiency Virus type-1 (HIV) infected Children 2 through 18 years of Age.
- HIV-1 gp120 Induced Expansion of Myeloid Derived Suppressor Cells is Dependent on Interleukin-6 and Suppresses Immunity.
- Effect of HIV genotypic drug resistance testing on the management and clinical course of HIV-infected children and adolescents.
- Conformity of Pediatric/Adolescent HIV Clinics to the Patient-Centered Medical Home Care Model.
- Genetic Variants in TLR -2, -4 and -9 and FC?RII are Associated with Antibody Response to Quadrivalent Meningococcal Conjugate Vaccine In HIV-Infected Youth.
- Vitamin D Attenuates Nucleoside Reverse Transcriptase Inhibitor Induced Human Skeletal Muscle Mitochondria DNA Depletion.
- Identification of a candidate therapeutic autophagy-inducing peptide.
- High proportions of regulatory B and T cells are associated with decreased cellular responses to pH1N1 influenza vaccine in HIV-infected children and youth (IMPAACT P1...
- Parallel Rapid HIV Testing in Pregnant Women at Tijuana General Hospital, Baja California, Mexico.
- Genetic Variants in the Host Restriction Factor APOBEC3G are Associated with HIV-1 Related Disease Progression and Central Nervous System Impairment in Children.
- Toll-Like Receptor 8 Ligands Activate a Vitamin D Mediated Autophagic Response that Inhibits Human Immunodeficiency Virus Type 1.
- Immunogenicity and safety of 1 vs 2 doses of quadrivalent meningococcal conjugate vaccine in youth infected with human immunodeficiency virus.
- Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1.
- Nevirapine Exposure with WHO Pediatric Weight Band Dosing - Enhanced Therapeutic Concentrations Predicted Based on Extensive International Pharmacokinetic Experience.
- The Influence of HLA on HIV-Associated Neurocognitive Impairment in Anhui, China.
- Predictors of highly active antiretroviral therapy utilization for behaviorally HIV-1-infected youth: impact of adult versus pediatric clinical care site.
- Vitamin D Inhibits Human Immunodeficiency Virus Type 1 and Mycobacterium tuberculosis Infection in Macrophages through the Induction of Autophagy.
- Production of interferon α by human immunodeficiency virus type 1 in human plasmacytoid dendritic cells is dependent on induction of autophagy.
- Clinical Outcomes and Hospitalizations among Children Perinatally Infected with HIV-1 in Baja California, Mexico.
- Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis.
- Hormonally active vitamin D3 (1{alpha},25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.
- Vitamin D and HIV: Letting the Sun Shine In.
- HLA Alleles are Associated with Altered Risk for Disease Progression and Central Nervous System Impairment of HIV-Infected Children.
- Differential Induction of Rat Neuronal Excitotoxic Cell Death by Human Immunodeficiency Virus Type 1 Clade B and C Tat Proteins.
- Substance use in HIV-Infected women during pregnancy: self-report versus meconium analysis.
- CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy.
- Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins.
- Mother-to-child HIV transmission in a cohort of pregnant women diagnosed by rapid HIV testing at Tijuana General Hospital, Baja California, Mexico.
- HIV-1 clade B Tat, but not clade C Tat, increases X4 HIV-1 entry into resting but not activated CD4+ T cells.
- Human metapneumovirus associated with central nervous system infection in children.
- Vitamin D earns more than a passing grade.
- Host genetic determinants of human immunodeficiency virus infection and disease progression in children.
- CCL2 increases X4-tropic HIV-1 entry into resting CD4+ T cells.
- Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.
- Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells.
- An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1-related disease in children.
- Autophagy: an overlooked mechanism of HIV-1 pathogenesis and neuroAIDS?
- Undiagnosed respiratory viruses in children.
- Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection.
- Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction.
- Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors.
- Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral t...
- High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage.
- Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism.
- Human immunodeficiency virus type 1 subtype C Tat fails to induce intracellular calcium flux and induces reduced tumor necrosis factor production from monocytes.
- Human bocavirus: prevalence and clinical spectrum at a children's hospital.
- Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy.
- Perinatal HIV counseling and rapid testing in Tijuana, Baja California, Mexico: seroprevalence and correlates of HIV infection.
- The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells.
- Hospital and outpatient health services utilization among HIV-infected children in care 2000-2001.
- Immunologic function and virologic suppression among children with perinatally acquired HIV Infection on highly active antiretroviral therapy.
- Myelomeningocele in an infant with intrauterine exposure to efavirenz.
- Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load.
- Migration and risk factors for HIV acquisition in pregnant women in Baja California, Mexico.
- Human cytomegalovirus-specific CD4+-T-cell cytokine response induces fractalkine in endothelial cells.
- Treatment of infants coinfected with HIV-1 and cytomegalovirus with combination antiretrovirals and ganciclovir.
- Decrease in hospitalization and mortality rates among children with perinatally acquired HIV type 1 infection receiving highly active antiretroviral therapy.
- Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children.
- Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States.
- Intrapatient variability of efavirenz concentrations as a predictor of virologic response to antiretroviral therapy.
- Impaired lymphoid chemokine-mediated migration due to a block on the chemokine receptor switch in human cytomegalovirus-infected dendritic cells.
- Lack of protective effects of interleukin-4 -589-C/T polymorphism against HIV-1-related disease progression and central nervous system impairment, in children.
- Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with ...
- Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA.
- Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children.
- HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
- Protease inhibitors and decreased birth weight in HIV-infected pregnant women with impaired glucose tolerance.
- Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus...
- Detection of replication-competent human immunodeficiency virus type 1 (HIV-1) in cultures from patients with levels of HIV-1 RNA in plasma suppressed to less than 500...
- Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children.
- Characterization of Functional Antibody and Memory B-Cell Responses to pH1N1 Monovalent Vaccine in HIV-Infected Children and Youth.
- Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.
Schools
Tufts University
Calif Moffitt Hospital
University Calif
Doctors Specialties
- Pediatric Infectious Disease Medicine
- Pediatric Infectious Disease
Accepted Insurances
Awards
- Honored
- Fellow (FAAP)
Education
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University of California San Diego -
UCSF -
Tufts University School of Medicine
Hospital
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Rady Children's Hospital - San Diego
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