Professor, Genetics, Perelman School of Medicine
Hematology
Dr. Stephen A. Liebhaber, MD
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Stephen A. Liebhaber works in the field of Hematology. He received 1 awards: "Investigator Alumnus". Stephen A. Liebhaber, MD has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Tritium-arrested human diploid fibroblasts maintain balanced RNA and protein metabolism.'
Publications
- Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.
- Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster.
- αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome.
- Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs.
- The Poly(C) binding protein Pcbp2, and its retrotransposed derivative Pcbp1, are independently essential to mouse development.
- Autonomous actions of the human growth hormone long-range enhancer.
- An auto-regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus.
- Cytoplasmic poly(a) binding protein C4 serves a critical role in erythroid differentiation.
- Tissue specific CTCF occupancy and boundary function at the human growth hormone locus.
- Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.
- αCP Poly(C) binding proteins act as global regulators of alternative polyadenylation.
- Identification of a secondary promoter within the human B-cell receptor component gene, hCD79b.
- Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression.
- DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.
- Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis.
- An RNA-Independent Linkage of Noncoding Transcription to Long-Range Enhancer Function.
- Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.
- An RNA-protein complex links enhanced nuclear 3' processing with cytoplasmic mRNA stabilization.
- The poly(rC)-binding protein {alpha}CP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation.
- The Role of the hGH Locus Control Region in Somatotrope Restriction of hGH-N Gene Expression.
- Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage.
- Too much PABP, too little translation.
- miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.
- Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1...
- Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism.
- Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay.
- An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene.
- Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.
- Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an indepen...
- A cell type-restricted mRNA surveillance pathway triggered by ribosome extension into the 3' untranslated region.
- The 3' untranslated region complex involved in stabilization of human alpha-globin mRNA assembles in the nucleus and serves an independent role as a splice enhancer.
- The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context.
- A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions.
- Locus control region transcription plays an active role in long-range gene activation.
- Shared stabilization functions of pyrimidine-rich determinants in the erythroid 15-lipoxygenase and alpha-globin mRNAs.
- Tissue-specific chromatin modifications at a multigene locus generate asymmetric transcriptional interactions.
- Butyrate increases the efficiency of translation of gamma-globin mRNA.
- Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.
- Neurobeachin is essential for neuromuscular synaptic transmission.
- Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation.
- Activation of the human GH gene cluster: roles for targeted chromatin modification.
- A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins.
- Identification of mRNAs associated with alphaCP2-containing RNP complexes.
- Regulation of alpha-globin mRNA stability.
- In vivo association of the stability control protein alphaCP with actively translating mRNAs.
- The KH-domain protein alpha CP has a direct role in mRNA stabilization independent of its cognate binding site.
- Specification of unique Pit-1 activity in the hGH locus control region.
- Targeting a KH-domain protein with RNA decoys.
- The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.
- 129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment.
- ZAP70 expression assessed by immunohistochemistry on peripheral blood: a simple prognostic assay for patients with chronic lymphocytic leukemia.
- Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes.
- The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression.
- Effects of local mRNA structure on posttranscriptional gene silencing.
- The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin.
- MicroRNA silencing through RISC recruitment of eIF6.
- Bystander gene activation by a locus control region.
- A defined locus control region determinant links chromatin domain acetylation with long-range gene activation.
- Differences in rRNA metabolism of primary and SV40-transformed human fibroblasts.
- Tritium-arrested human diploid fibroblasts maintain balanced RNA and protein metabolism.
- Suppressor T cells.
- The response of T cells to histocompatibility-2 antigens. Dose-response kinetics.
- Bidirectional effects of interaction between parental thymocytes and F1 spleen cells in the production of graft vs host splenomegaly.
- Significance of cell interactions in production of graft versus host splenomegaly.
- Dual pathways for ribonucleic acid turnover in WI-38 but not in I-cell human diploid fibroblasts.
- Translationally associated helix-destabilizing activity in rabbit reticulocyte lysate.
- Nucleic Acid degradation.
- PERK-dependent regulation of IAP translation during ER stress.
- Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.
- Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster.
- Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism.
- High-level production of human alpha- and beta-globins in insect cells.
- Translation inhibition by an mRNA coding region secondary structure is determined by its proximity to the AUG initiation codon.
- Developmental switching of messenger RNA expression from the human alpha-globin cluster: fetal/adult pattern of theta-globin gene expression.
- Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript.
- Developmental switch in the relative expression of the alpha 1- and alpha 2-globin genes in humans and in transgenic mice.
- Human embryonic zeta-globin chain expression in deletional alpha-thalassemias.
- A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms.
- Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.
- Human alpha-globin genes demonstrate autonomous developmental regulation in transgenic mice.
- Alpha-thalassemia resulting from deletion of regulatory sequences far upstream of the alpha-globin structural genes.
- Human growth hormone variant produces insulin-like and lipolytic responses in rat adipose tissue.
- Substrate specificity of the dsRNA unwinding/modifying activity.
- Binding of human growth hormone (GH)-variant (placental GH) to GH-binding proteins in human plasma.
- Human growth hormone-variant is a biologically active somatogen and lactogen.
- Identification of a splice-site mutation in the human growth hormone-variant gene.
- Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif.
- Alteration in the receptor binding specificity of human growth hormone by genomic exon exchange.
- A difference in the splicing patterns of the closely related normal and variant human growth hormone gene transcripts is determined by a minimal sequence divergence be...
- Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg)
- Human growth hormone-variant demonstrates a receptor binding profile distinct from that of normal pituitary growth hormone.
- Alpha thalassemia.
- Characterization and histologic localization of human growth hormone-variant gene expression in the placenta.
- Glycosylated human growth hormone variant.
- Theta, zeta, and epsilon globin messenger RNAs are expressed in adults.
- Locus assignment of two alpha-globin structural mutants from the Caribbean basin: alpha Fort de France (alpha 45 Arg) and alpha Spanish Town (alpha 27 Val).
- Locus assignment of alpha-globin structural mutations by hybrid-selected translation.
- Synthesis of growth hormone-prolactin chimeric proteins and processing mutants by the exchange and deletion of genomic exons.
- Destabilization of messenger RNA/complementary DNA duplexes by the elongating 80 S ribosome.
- Evidence for posttranslational control of Hb C synthesis in an individual with Hb C trait and alpha-thalassemia.
Schools
Yale University
Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Investigator Alumnus
Education
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Washington University - Barnes-Jewish Hospital -
University of Colorado -
Case Western Reserve University - MetroHealth
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