Professor of Medicine, Beth Israel Deaconess Medical Center
Nephrology
Dr. Seth L. Alper, MD
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Seth Alper practices Nephrology. He studied medicine at Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care He over the years received 1 awards: "Fellow (ASNF)". Seth Alper is also published. He has 84 publications published. The lastest publication: "Atypical patterns of segregation of familial enlargement of the vestibular aqueduct.'
Publications
- Atypical patterns of segregation of familial enlargement of the vestibular aqueduct.
- Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.
- Hereditary xerocytosis revisited.
- Evolution of the primate trypanolytic factor APOL1.
- Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger.
- Short-term responses of the kidney to high altitude in mountain climbers.
- Molecular Dynamics Simulations of the STAS Domains of Rat Prestin and Human Pendrin Reveal Conformational Motions in Conserved Flexible Regions.
- Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report.
- Use of SLC26A4 Mutation Testing for Unilateral Enlargement of the Vestibular Aqueduct.
- TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.
- Strain-specific variations in cation content and transport in mouse erythrocytes.
- The SLC26 gene family of anion transporters and channels.
- Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis.
- Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout.
- Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.
- SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts.
- Substitution of transmembrane domain Cys residues alters pH(o)-sensitive anion transport by AE2/SLC4A2 anion exchanger.
- Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK.
- The Pendrin Anion Exchanger Gene is Transcriptionally Regulated by Uroguanylin: A Novel Entero-Renal Link.
- Guanine nucleotides differentially modulate backbone dynamics of the STAS domain of the SulP/SLC26 transport protein Rv1739c of M. tuberculosis.
- This, too, shall pass - like a kidney stone: a possible path to prophylaxis of nephrolithiasis?
- Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.
- A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1.
- SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization.
- Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis.
- Solution structure of the guanine nucleotide-binding STAS domain of SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.
- Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange.
- Tubular transport: core curriculum 2010.
- Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D.
- Anion exchanger 1 interacts with nephrin in podocytes.
- Regulated transport of sulfate and oxalate by SLC26A2/DTDST.
- AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon.
- The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes.
- Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.
- Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass.
- Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion.
- Efficient molecular genetic diagnosis of enlarged vestibular aqueducts in East Asians.
- Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss.
- Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.
- Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells.
- Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter.
- Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental p...
- Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH.
- HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization.
- Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach.
- Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest.
- Let's look at cysts from both sides now.
- Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity.
- Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass.
- Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes.
- Zebrafish ae2.2 encodes a second slc4a2 anion exchanger.
- Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.
- Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice.
- Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.
- Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters.
- Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
- Hypertonicity triggers RhoA-dependent assembly of myosin-containing striated polygonal actin networks in endothelial cells.
- Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO(3)(-) exchanger AE1.
- Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1).
- Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induc...
- IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.
- Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain.
- Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols.
- Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization.
- The abts and sulp families of anion transporters from Caenorhabditis elegans.
- Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes.
- Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity.
- Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain.
- Regulation of the Cl-/HCO3- exchanger AE2 in rat thick ascending limb of Henle's loop in response to changes in acid-base and sodium balance.
- Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.
- Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.
- Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric.
- Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
- Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells.
- Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer.
- KCl cotransport is an important modulator of human cervical cancer growth and invasion.
- Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells.
- Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity.
- Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.
- Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis.
- Genetic diseases of acid-base transporters.
- How pH regulates a pH regulator: a regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger.
- Cellular actions and signaling by endostatin.
Schools
Yale University School Of Medicine
Beth Israel Deaconess Hospital
Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Fellow (ASNF)
Education
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Beth Israel Deaconess Medical Center -
Yale University School of Medicine
Hospital
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Beth Israel Deaconess Medical Center
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