Professor, Dermatology and Cutaneous Biology, Jefferson Medical College-Thos Jefferson Univ
Rheumatology
Dr. Sergio A. Jimenez, MD
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Sergio Jimenez is an expert in the field of Rheumatology. He received awards:"CMS Meaningful Use Stage 1 Certification" and "Super Doctor". Sergio Jimenez has written publications. He has 65 publications published with PubMed. The lastest publication is: 'Severe eosinophilic fasciitis: comparison of treatment with d-penicillamine plus corticosteroids vs. corticosteroids alone.'
Publications
- Severe eosinophilic fasciitis: comparison of treatment with d-penicillamine plus corticosteroids vs. corticosteroids alone.
- Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs.
- Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis.
- Induction of a type I interferon signature in normal human monocytes by gadolinium-based contrast agents: comparison of linear and macrocyclic agents.
- Acute retinal artery occlusion in systemic sclerosis: A rare manifestation of systemic sclerosis fibroproliferative vasculopathy.
- Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro.
- Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function.
- Systemic sclerosis disease modification clinical trials design: Quo vadis?
- Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases.
- A Prospective Observational Study of Mycophenolate Mofetil Treatment in Progressive Diffuse Cutaneous Systemic Sclerosis of Recent Onset.
- Effect of oxidative stress on protein tyrosine phosphatase-1B in scleroderma dermal fibroblasts.
- Scleroderma renal crisis-like acute renal failure associated with mucopolysaccharide accumulation in renal vessels in a patient with scleromyxedema.
- Tyrosine kinase inhibitor therapy for systemic sclerosis: Quo vadis?
- Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders.
- Protein kinase C δ and the c-Abl kinase are required for transforming growth factor-β induction of endothelial-mesenchymal transition in vitro.
- Effect of Protein Kinase C delta (PKC-?) Inhibition on the Transcriptome of Normal and Systemic Sclerosis Human Dermal Fibroblasts In Vitro.
- 46, XX SRY-positive male syndrome presenting with primary hypogonadism in the setting of scleroderma.
- Proteomic analysis identification of a pattern of shared alterations in the secretome of dermal fibroblasts from systemic sclerosis and nephrogenic systemic fibrosis.
- Maternal mixed connective tissue disease and offspring with chondrodysplasia punctata.
- Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies.
- Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells.
- Mechanism of NSF: New evidence challenging the prevailing theory.
- Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics.
- Induction of the expression of profibrotic cytokines and growth factors in normal human peripheral blood monocytes by gadolinium contrast agents.
- Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
- Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis.
- Angiotensin II blockade in Marfan's syndrome.
- Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis.
- Molecular ablation of transforming growth factor beta signaling pathways by tyrosine kinase inhibition: the coming of a promising new era in the treatment of tissue fi...
- Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis.
- Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors.
- T cells expressing allograft inflammatory factor 1 display increased chemotaxis and induce a profibrotic phenotype in normal fibroblasts in vitro.
- Regulation of the human SOX9 promoter by Sp1 and CREB.
- Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy: clinical aspects.
- The role of allograft inflammatory factor 1 in systemic sclerosis.
- Expression of allograft inflammatory factor 1 in tissues from patients with systemic sclerosis and in vitro differential expression of its isoforms in response to tran...
- Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin.
- Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literature.
- Single amino acid substitutions in the C-terminus of collagen II alter its affinity for collagen IX.
- Demonstration of autoimmunity in the tight skin-2 mouse: a model for scleroderma.
- Case 35-2004: nephrogenic fibrosing dermopathy.
- Scleroderma fibroblast survival in Aktion.
- Microchimerism and systemic sclerosis.
- Position of single amino acid substitutions in the collagen triple helix determines their effect on structure of collagen fibrils.
- A role for the androgen receptor in collagen content of the skin.
- Involvement of skeletal muscle in dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy).
- Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches.
- Dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy): study of inflammatory cells and transforming growth factor beta1 expression in affected skin.
- Impaired rectoanal inhibitory response in scleroderma (systemic sclerosis): an association with fecal incontinence.
- Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis.
- Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.
- Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743.
- Transcriptional activation of alpha 1(III) procollagen gene in Tsk2/+ dermal fibroblasts.
- Detection of microchimeric cells in the peripheral blood of nonpregnant women is enhanced by magnetic cell sorting before PCR.
- Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9.
- Murine animal models of systemic sclerosis.
- Inhibition of basal and transforming growth factor-beta-induced stimulation of COL1A1 transcription by the DNA intercalators, mitoxantrone and WP631, in cultured human...
- Increased microchimeric CD4+ T lymphocytes in peripheral blood from women with systemic sclerosis.
- Oligoclonal T cell expansion in the skin of patients with systemic sclerosis.
- Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase.
- Hepatitis C virus infection, inflammatory myopathy, and pulmonary fibrosis: are they related?
- Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis.
- Role of Endothelial to Mesenchymal Transition in the Pathogenesis of the Vascular Alterations in Systemic Sclerosis.
- Collagen Content in Skin and Internal Organs of the Tight Skin Mouse: An Animal Model of Scleroderma.
Schools
National Higher University of San Marcos Academy of Human Medicine
Philadelphia General Hospital
Hospital University Pa
Mayo Grad School
Doctors Specialties
- Internal Medicine
- Rheumatology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Super Doctor
Education
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Mayo School of Graduate Medical Education -
National University of San Marcos
Hospital
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Thomas Jefferson University Hospital
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