Professor of Pediatrics, Johns Hopkins University School of Medicine; Director of Pediatric Endocrinology, Lawson Wilkins Professor
Pediatric Endocrinology
Dr. Sally Radovick, MD
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Sally Radovick, MD works in the field of Pediatric Endocrinology. He studied medicine at Northeast Ohio Medical University. He received awards:"Elected Member". Sally Radovick is also a published doctor. He has 90 paper published. The most recent paper is: A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein.
Publications
- Developmental and endocrine regulation of kisspeptin expression in mouse leydig cells.
- Positive, but not negative feedback actions of estradiol in female mice require estrogen receptor α (ERα) in kisspeptin neurons.
- Potential biomarker of metformin action.
- Glucagon regulates hepatic kisspeptin to impair insulin secretion.
- Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism.
- Preterm birth and random plasma insulin levels at birth and in early childhood.
- Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell.
- Both Estrogen Receptor Alpha and Beta Stimulate Pituitary GH Gene Expression.
- Activation of Basal Gluconeogenesis by Coactivator p300 Maintains Hepatic Glycogen Storage.
- Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells.
- Vertical Transmission of Hypopituitarism: Critical Importance of Appropriate Interpretation of Thyroid Function Tests and Levothyroxine Therapy During Pregnancy.
- Genetic Mechanisms Mediating Kisspeptin Regulation of GnRH gene Expression.
- CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
- Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice.
- CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.
- Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates.
- cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes.
- CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression.
- Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.
- Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.
- A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein.
- Direct regulation of GnRH transcription by CRF-like peptides in an immortalized neuronal cell line.
- Leptin levels in children with central precocious puberty.
- The molecular basis of hypopituitarism.
- The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty.
- Regulation of gonadotropin-releasing hormone (GnRH) gene expression by insulin-like growth factor I in a cultured GnRH-expressing neuronal cell line.
- An alternative gonadotropin-releasing hormone (GnRH) RNA splicing product found in cultured GnRH neurons and mouse hypothalamus.
- Phorbol ester regulation of the gonadotropin-releasing hormone (GnRH) gene in GnRH-secreting cell lines: a molecular basis for species differences.
- Primary hypothyroidism presenting as severe vaginal bleeding in a prepubertal girl.
- Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.
- Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells.
- Cell-specific expression of the human gonadotropin-releasing hormone gene in transgenic animals.
- A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene.
- AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.
- A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.
- Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals.
- Cloning of the human thyrotropin beta-subunit gene and transient expression of biologically active human thyrotropin after gene transfection.
- Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.
- Pre-translational and post-translational regulation of TSH synthesis in normal and neoplastic thyrotrophs.
- Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species.
- Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.
- Analysis of gonadotropin-releasing hormone gene structure in families with familial central precocious puberty and idiopathic hypogonadotropic hypogonadism.
- Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone.
- Pre-translational and post-translational regulation of TSH: relationship to bioactivity.
- Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.
- Evidence for direct estrogen regulation of the human gonadotropin-releasing hormone gene.
- Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thy...
- Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3.
- A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.
- A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.
- Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1.
- Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-beta subunit gene expression.
- Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse.
- Development of an immortalised, post-pubertal gonadotrophin-releasing hormone neuronal cell line.
- Pubertal development and menarche.
- Long-Term Surveillance of Growth Hormone Therapy.
- Novel mutations associated with combined pituitary hormone deficiency.
- Deletion of otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism.
- The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity.
- Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons.
- Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
- Divergent roles of growth factors in the GnRH regulation of puberty in mice.
- Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model.
- Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines.
- Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.
- Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1).
- Estrogen regulation of gene expression in GnRH neurons.
- Endocrinology of female puberty.
- Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology.
- Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice.
- A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency.
- Community and family perspectives on addressing overweight in urban, African-American youth.
- Does treatment of childhood congenital adrenal hyperplasia with prednisone adversely affect final height?
- Approach to the growth hormone-deficient child during transition to adulthood.
- Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin.
- In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone.
- A novel technique for temporally regulated cell type-specific Cre expression and recombination in the pituitary gonadotroph.
- Deciphering the genetics of stature--another piece of the puzzle.
- Insulin augments GnRH-stimulated LHbeta gene expression by Egr-1.
- Bisphosphonate treatment of pediatric bone disease.
- The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency.
- Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee.
- Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia.
- Molecular mechanisms responsible for combined pituitary hormone deficiency.
- The GnRH neuron: molecular aspects of migration, gene expression and regulation.
- Other transcription factors and hypopituitarism.
- Molecular basis of combined pituitary hormone deficiencies.
- Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcripti...
- Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo.
Schools
Northeastern Ohio Universities College Of Medicine
Rainbow BabiesChldnsCase
National Institute Of Health
Doctors Specialties
- Pediatric Endocrinology
Accepted Insurances
- Amerigroup (Wellpoint)
- Blue Card PPO
- Blue Choice Advantage
- Blue Choice Network POS
- Blue Preferred PPO
- CareFirst Maryland POS
- Commercial Insurance Company
- Southern Health PPO
- Geisinger Health Plan
- Choice Care PPO
- Medicaid
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Options PPO
Awards
- Elected Member
Education
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Case Western Reserve University - University Hospitals -
Northeast Ohio Medical University
Hospital
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Johns Hopkins Hospital -
Robert Wood Johnson University Hospital
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