Physician
Pathology
Dr. Russell R. Broaddus, MD
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Russell Broaddus practices Pathology. He graduated from Baylor College of Medicine. Doctor Russell R. Broaddus, MD is also published. He has 101 publications published. The lastest publication: "Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.' He accepts all Medicare patients.
Publications
- Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.
- Cytokine Stimulation of MUC4 Expression in Human Female Reproductive Tissue Carcinoma Cell Lines and Endometrial Cancer.
- Use of clinical next-generation sequencing to identify melanomas harboring SMARCB1 mutations.
- Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.
- Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.
- Identifying aggressive forms of endometrioid-type endometrial cancer: new insights into molecular subtyping.
- Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation.
- Combined colonoscopy and endometrial biopsy cancer screening results in women with Lynch syndrome.
- Naturally Occurring Neomorphic PIK3R1 Mutations Activate the MAPK Pathway, Dictating Therapeutic Response to MAPK Pathway Inhibitors.
- Clinically Significant Endometrial Cancer Risk Following a Diagnosis of Complex Atypical Hyperplasia.
- Expression of Estrogen-Induced Genes and Estrogen Receptor β in Pancreatic Neuroendocrine Tumors: Implications for Targeted Therapy.
- Clinical Significance of CTNNB1 Mutation and Wnt Pathway Activation in Endometrioid Endometrial Carcinoma.
- Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations.
- Fallopian Tube High-grade Serous Carcinoma With Intramucosal Spread and Presenting as a Malignancy on Pap Smear.
- Evaluation of Clinical Criteria for the Identification of Lynch Syndrome among Unselected Patients with Endometrial Cancer.
- Consequences of universal MSI/IHC in screening ENDOMETRIAL cancer patients for lynch syndrome.
- Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome.
- CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity.
- The Search Continues: Looking for Predictive Biomarkers for Response to Mammalian Target of Rapamycin Inhibition in Endometrial Cancer.
- Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H).
- Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors.
- Crosstalk between EphA2 and BRaf/CRaf is a Key Determinant of Response to Dasatinib.
- Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy.
- β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition.
- Molecular pathogenesis of endometrial cancers in patients with Lynch syndrome.
- Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Synd...
- Critical Tumor Suppressor Function Mediated by Epithelial Mig-6 in Endometrial Cancer.
- Utility of MLH1 Methylation Analysis in the Clinical Evaluation of Lynch Syndrome in Women with Endometrial Cancer.
- Relationship between PTEN, DNA mismatch repair, and tumor histotype in endometrial carcinoma: retained positive expression of PTEN preferentially identifies sporadic n...
- Chemopreventive effects of metformin on obesity-associated endometrial proliferation.
- Integrated Analyses Identify a Master MicroRNA Regulatory Network for the Mesenchymal Subtype in Serous Ovarian Cancer.
- Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization.
- Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
- Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant low-grade serous carcinoma of the ovary, peritoneum, or fallopian tube.
- Integrated analysis of gene expression and tumor nuclear image profiles associated with chemotherapy response in serous ovarian carcinoma.
- Uterine Serous Carcinoma: Increased Familial Risk for Lynch-Associated Malignancies.
- Personalized therapy in endometrial cancer: Challenges and opportunities.
- Pathologic scoring of PTEN immunohistochemistry in endometrial carcinoma is highly reproducible.
- Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.
- Identification of Cancer Patients with Lynch Syndrome: Clinically Significant Discordances and Problems in Tissue Based Mismatch Repair Testing.
- High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability.
- Molecular clustering based on ERα and EIG121 predicts survival in high-grade serous carcinoma of the ovary/peritoneum.
- Clinicodemographic factors influencing outcomes in patients with low-grade serous ovarian carcinoma.
- Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer.
- A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma.
- Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.
- Loss of inhibitory insulin receptor substrate-1 phosphorylation: An early event in endometrial hyperplasia and progression to carcinoma.
- Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.
- Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signal...
- Microscopic evaluation of lymph-node-bearing tissue in early-stage cervical cancer: a dual-institution review.
- Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma.
- Primary peritoneal cancer after bilateral salpingo-oophorectomy in two patients with Lynch syndrome.
- Mouse models of uterine corpus tumors: clinical significance and utility.
- Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression.
- S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling.
- Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway.
- Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.
- Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.
- Clinicopathological features in endometrial carcinoma associated with Lynch syndrome in China.
- Enhanced estrogen-induced proliferation in obese rat endometrium.
- Endometrial cancer and Lynch syndrome: clinical and pathologic considerations.
- Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome.
- AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
- Differential roles of telomere attrition in type I and II endometrial carcinogenesis.
- ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease.
- Role of PELP1/MNAR signaling in ovarian tumorigenesis.
- Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat.
- Regulation of inflammatory responses by IL-17F.
- Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.
- Primary liver sarcoma in an immunocompetent patient with hepatitis C virus infection.
- Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.
- Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer.
- Generation of a Mig-6 conditional null allele.
- Hypomethylation-induced expression of S100A4 in endometrial carcinoma.
- Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer.
- Serology- and biopsy-proven celiac disease in a patient with AIDS: case report.
- Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.
- Florid cystic endosalpingiosis presenting as an obstructive colon mass mimicking malignancy: case report and literature review.
- Lymphatic mapping and sentinel node biopsy in women with high-risk endometrial cancer.
- Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium.
- The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary.
- Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas.
- The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers.
- Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant epithelial ovarian and primary peritoneal cancers.
- Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma.
- Women with HNPCC: a target population for the chemoprevention of gynecologic cancers.
- Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?
- Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer.
- Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis.
- Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia.
- Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas.
- BRAF mutations in aberrant crypt foci and hyperplastic polyposis.
- Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndrome.
- Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endom...
- Expression of imatinib mesylate-targeted kinases in endometrial carcinoma.
- Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer.
- Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
- Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome.
- Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases.
- The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas.
Schools
University of Texas At Houston Medical School At Houston
Baylor College Of Med
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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Baylor College of Medicine -
University of Texas Medical School
Hospital
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University of Texas M.D. Anderson Cancer Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1891881967 |
| Last Name Of The Provider | BROADDUS |
| First Name Of The Provider | RUSSELL |
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