Associate Professor of Medicine, Massachusetts General Hospital

Internal Medicine

Soberman is an expert in the field of Internal Medicine. Soberman is a published physician. He has 101 papers published. The most current publication "Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase."

Publications

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• CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.
• The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer.
• An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma.
• Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis.
• 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.
• The nuclear membrane organization of leukotriene synthesis.
• Revisiting prostacyclin: new directions in pulmonary fibrosis and inflammation.
• Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human pol...
• The membrane organization of leukotriene synthesis.
• Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter.
• The organization and consequences of eicosanoid signaling.
• The expanding network of redox signaling: new observations, complexities, and perspectives.
• Membrane localization and topology of leukotriene C4 synthase.
• The CD200-CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host-Pathogen Interactions.
• Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region.
• Percutaneous transluminal dilation in renal transplant arterial stenosis.
• Late follow-up of percutaneous transluminal angioplasty for treatment of transplant renal artery stenosis.
• The clinical use of steroids in pancreatic transplantation.
• Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes.
• Clinical segmental pancreatic transplantation with ureter-to-pancreatic duct anastomosis for exocrine drainage.
• Plasma and red cell cholinesterase activity in uremic patterns (effects of hemodialysis and renal transplantation).
• Long-term effects of pancreatic transplant function in patients with advanced juvenile-onset diabetes.
• Long-term patient survival after cadaver renal transplantation.
• No association between post-transplant erythrocytosis, thromboembolic events, and cyclosporine therapy.
• Long-term results of O-antigen match cadaver transplants--a single-institution study.
• Successful transplantation after conversion of a positive crossmatch to negative by dissociation of IgM antibody.
• When further ALG administration becomes futile.
• Timing of cyclosporine administration in patients with delayed graft function.
• Recurrent membranoproliferative glomerulonephritis type 1 in successive renal transplants.
• The effect of the referring dialysis center on renal transplant results.
• Individualization of immediate posttransplant immunosuppression. The value of antilymphocyte globulin in patients with delayed graft function.
• Successful transplantation of highly sensitized patients without regard to HLA matching.
• Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor.
• 2,8-dihydroxyadenine urolithiasis: report of a case first diagnosed after renal transplant.
• Renal transplantation in patients with a history of heroin abuse.
• Transplantation of pediatric donor kidneys to adult recipients. Is there a critical donor age?
• ALG treatment of steroid-resistant rejection in patients receiving cyclosporine.
• Definition, diagnosis, and management of rejection in the second to sixth months posttransplant--an overview.
• Simultaneous bilateral posterior nephrectomy in transplant recipients.
• Pancreatic transplantation in New York.
• Clinical segmental pancreatic transplantation with ureter-pancreatic duct anastomosis for exocrine drainage.
• The fate of the renal transplant with delayed function.
• Effects of hemodialysis and renal transplantation on pulmonary function.
• Pancreatic duct to ureter anastomosis for exocrine drainage in pancreatic transplantation.
• Irreversible liver damage after azathioprine.
• The value of needle renal allograft biopsy. III. A prospective study.
• Cyclosporine: preliminary experience in 79 patients with renal transplants.
• Treatment of renal transplant rejection episodes in patients receiving prednisone and azathioprine. A cost-effective approach.
• Male fertility in cyclosporine-treated renal transplant patients.
• Activation energy for water diffusion across the toad bladder: evidence against the pore enlargement hypothesis.
• Internal arteriovenous fistulae in a hemodialysis-transplant program.
• The value of needle renal allograft biopsy. II: Reflection of acute rejection changes throughout the kidney by percutaneous biopsy.
• Single lung transplantation in paraquat intoxication.
• Successful kidney transplantation with current-sera-negative/historical-sera-positive T cell crossmatch.
• Regulated formation of eicosanoids.
• Differential localization of 5- and 15-lipoxygenases to the nuclear envelope in RAW macrophages.
• Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.
• Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase.
• Joining of DNA fragments by repeated cycles of denaturation, annealing and extension.
• The fate of the patient returned to hemodialysis after losing a renal transplant.
• Radioimmunoassay for leukotriene B4.
• Internal arteriovenous fistula for hemodialysis.
• Purification of human leukotriene C4 synthase.
• Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells.
• omega-Hydroxylation of 15-hydroxyeicosatetraenoic acid by lung microsomes from pregnant rabbits.
• Oxidation of 15-hydroxyeicosatetraenoic acid and other hydroxy fatty acids by lung prostaglandin dehydrogenase.
• Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuc...
• Properties of highly purified leukotriene C4 synthase of guinea pig lung.
• Leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
• 5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes.
• Antilymphoblast globulin treatment of steroid-resistant rejection in cyclosporine-immunosuppressed renal transplant recipients.
• Leukotriene C4 synthase from rat basophilic leukemia cell microsomes.
• Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3.
• Eosinophils cocultured with endothelial cells have increased survival and functional properties.
• Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts.
• Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase.
• Critical considerations in the development of an assay for sulfidopeptide leukotrienes in plasma.
• Workshop: Potential therapeutic uses of inhibitors of leukotriene generation and function. June 23, 1986, Bethesda, Maryland. Sponsored by the National Institute of Al...
• Synthesis and release of leukotriene C4 by human eosinophils.
• Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
• Kinetics of the arachidonic acid 5- and 15-lipoxygenases of the human polymorphonuclear leukocyte.
• Perspectives on additional areas for research in leukotrienes.
• The identification and formation of 20-aldehyde leukotriene B4.
• Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.
• Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.
• The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils.
• Enzymes of the 5-lipoxygenase pathway.
• Identification of an aldehyde dehydrogenase in the microsomes of human polymorphonuclear leukocytes that metabolizes 20-aldehyde leukotriene B4.
• The cell biology and biochemistry of leukotriene C4 biosynthesis.
• Letter: Carbamazepine in uremic neuropathy.
• Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony s...
• A morphometric study of normodense and hypodense human eosinophils that are derived in vivo and in vitro.
• Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes.
• Cytochrome P-450LTB and inactivation of leukotriene B4.
• Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.
• The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes.
• Docosahexaenoic acid, a constituent of rodent fetal serum and fish oil diets, inhibits acquisition of macrophage tumoricidal function.
• Covalent linkage of prosthetic heme to CYP4 family P450 enzymes.
• Alternative splicing determines the function of CYP4F3 by switching substrate specificity.
• Metabolism of purines in macrophages. Effect of functional state of the cells.

Schools

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• New York University

• Bellevue Hospital Center

• Harvard Med Center

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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