Associate Professor of Psychiatry, Massachusetts General Hospital
Psychiatry
Dr. Roy H. Perlis, MD
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Roy H. Perlis, MD works in the field of Psychiatry. He attended Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care Dr. Roy H. Perlis is a published doctor as well. He has 100 publications published. The latest was: A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder.
Publications
- A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder.
- Discriminating Between Bipolar Disorder and Major Depressive Disorder.
- Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study.
- Contributions of the social environment to first-onset and recurrent mania.
- Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.
- Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.
- A tool to utilize adverse effect profiles to identify brain-active medications for repurposing.
- Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
- Use of large data sets and the future of personalized treatment.
- Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.
- Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.
- An Electronic Health Records Study of Long-Term Weight Gain Following Antidepressant Use.
- Bipolar polygenic loading and bipolar spectrum features in major depressive disorder.
- Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder.
- Pharmacogenomic Testing and Personalized Treatment of Depression.
- Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association.
- Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorde...
- Translation: Screening for Novel Therapeutics With Disease-Relevant Cell Types Derived from Human Stem Cell Models.
- A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder.
- Association Between Therapeutic Alliance, Care Satisfaction, and Pharmacological Adherence in Bipolar Disorder.
- A Clinical Risk Stratification Tool for Predicting Treatment Resistance in Major Depressive Disorder.
- Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease.
- QT interval and antidepressant use: a cross sectional study of electronic health records.
- Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis.
- Epigenetic mechanisms in mood disorders: Targeting neuroplasticity.
- Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.
- Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: ...
- Copy Number Variation in Subjects with Major Depressive Disorder Who Attempted Suicide.
- Do suicidal thoughts or behaviors recur during a second antidepressant treatment trial?
- Cognitive therapy for anxious depression in STAR(â)D: What have we learned?
- Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development.
- Risks for the transition from major depressive disorder to bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions.
- Limbic system white matter microstructure and long-term treatment outcome in major depressive disorder: A diffusion tensor imaging study using legacy data.
- Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder.
- Hard outcomes: clinical trials to reduce suicide.
- Sleep disturbance in euthymic bipolar patients.
- Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Genetic Variation and Stress Interact to Influence Reward Learning.
- Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework.
- Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
- Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder.
- Betting on biomarkers.
- A critical review of pharmacotherapy for major depressive disorder.
- L-type calcium channels and psychiatric disorders: A brief review.
- Transition to mania during treatment of bipolar depression.
- Personalized medicine for depression: can we match patients with treatments?
- Can single genes matter in a polygenic world?
- Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
- The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
- Neuroleptic malignant syndrome: further lessons from a case report.
- Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.
- Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression.
- Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder.
- Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study.
- Assuring that double-blind is blind.
- Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report.
- Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans.
- Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder.
- Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study.
- Low-dose transdermal testosterone augmentation therapy improves depression severity in women.
- Does study design explain the relationship between conflict of interest and positive outcome in clinical trials in psychiatry?
- Pharmacogenetics studies in STAR*D: strengths, limitations, and results.
- Efficacy of electroconvulsive therapy in Fahr disease associated with bipolar psychotic disorder: a case report.
- When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study.
- A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.
- Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.
- Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.
- Effective agents in treating mania.
- Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
- Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD.
- Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD.
- Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study.
- Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?
- Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task.
- A roadmap to key pharmacologic principles in using antipsychotics in the treatment of bipolar disorder.
- Clinical insights into pharmacogenetics and schizophrenia, part 2.
- A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder.
- Efficacy of duloxetine for the treatment of depression: relationship to most recent antidepressant trial.
- Clinical decision making in the treatment of mania.
- Family-based association study of lithium-related and other candidate genes in bipolar disorder.
- Treatment of bipolar disorder: the evolving role of atypical antipsychotics.
- Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD.
- Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder.
- Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the ...
- Pharmacogenetic studies of antidepressant response: how far from the clinic?
- Concordance with treatment guidelines for bipolar disorder: data from the systematic treatment enhancement program for bipolar disorder.
- Early symptomatic worsening during treatment with fluoxetine in major depressive disorder: prevalence and implications.
- The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder.
- Olanzapine versus risperidone in the treatment of manic or mixed States in bipolar I disorder: a randomized, double-blind trial.
- A 24-week open-label extension study of olanzapine-fluoxetine combination and olanzapine monotherapy in the treatment of bipolar depression.
- Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials.
- A survey of antidepressant prescribing practices in major depression with comorbid attention-deficit hyperactivity disorder.
- Pharmacogenetics, race, and psychiatry: prospects and challenges.
- Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD.
- Clinical features of bipolar depression versus major depressive disorder in large multicenter trials.
- Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
- A meta-analysis of early sustained response rates between antidepressants and placebo for the treatment of major depressive disorder.
- The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry.
- Incidence of and risk factors for medical malpractice lawsuits among Mohs surgeons.
- Misdiagnosis of bipolar disorder.
Schools
Harvard Medical School
Mass General HospMcLean Hospital
Doctors Specialties
- Psychiatry
Accepted Insurances
Education
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Massachusetts General Hospital -
Harvard Medical School
Hospital
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Massachusetts General Hospital
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