Physician

Internal Medicine

Roger H. Griffin, MD is an expert in the field of Internal Medicine. He researched medicine at University of Pittsburgh School of Medicine. He over the years received 1 awards: "CMS Meaningful Use Stage 1 Certification". Roger Griffin has written publications. He has 43 publications published with PubMed. The lastest paper is: 'MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.'

Publications

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• MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.
• Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.
• Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301.
• Nucleoside transport inhibitors: structure-activity relationships for pyrimido[5,4-d]pyrimidine derivatives that potentiate pemetrexed cytotoxicity in the presence of ...
• Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.
• DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
• DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemot...
• Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.
• Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK).
• Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates.
• Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.
• Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.
• Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction.
• 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).
• DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell Chronic lymphocytic leukemia.
• Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase.
• Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2.
• Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inh...
• Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase ...
• A new strategy for the synthesis of taurine derivatives using the ''safety-catch'' principle for the protection of sulfonic acids.
• Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.
• Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
• Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination.
• Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
• Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
• Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.
• Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization ...
• Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
• Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
• Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside tran...
• Effect of Cell cycle inhibition on Cisplatin-induced cytotoxicity.
• N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
• Potentiation of cytotoxic drug activity in human tumour Cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
• Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol.
• 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
• Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
• Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
• 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
• Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
• Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
• Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.
• Designing inhibitors of cyclin-dependent kinases.

Schools

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• University Of Pittsburgh

• Miami Valley Hospital

• Presbyterian Hospital Pittsburgh

• University Of Cincinnati College Of Med

Procedures Preformed

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• Steroid Injection

Conditions Treated

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• Adhesive Capsulitis
• Antiphospholipid Syndrome (APS)
• Arthritis
• Bursitis
• View All

Doctors Specialties

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• Rheumatology
• Internal Medicine

Accepted Insurances

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Awards

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• CMS Meaningful Use Stage 1 Certification

Education

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• University of Pittsburgh Medical Center
• University of Pittsburgh School of Medicine

Hospital

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• Miami Valley Hospital

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