Physician
Hematology
Dr. Rodger P. McEver, MD
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Rodger McEver practices Hematology. He attended University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10/19 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Dr. Rodger P. McEver is a published doctor and has 101 publications published. The lastest was: 'Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein.'
Publications
- Neutrophils scan for activated platelets to initiate inflammation.
- Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin.
- Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets.
- Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.
- Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice.
- P-selectin glycoprotein ligand-1 forms dimeric interactions with e-selectin but monomeric interactions with L-selectin on cell surfaces.
- Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.
- Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.
- Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.
- Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.
- Regulation of catch bonds by rate of force application.
- Molecular stiffness of selectins.
- Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum.
- Differential regulation of human and murine P-selectin expression and function in vivo.
- Rolling cell adhesion.
- Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.
- E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.
- Core 1-derived O-glycans are essential E-selectin ligands on neutrophils.
- Rolling back neutrophil adhesion.
- Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane.
- Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation.
- Bending rigidities of cell surface molecules P-selectin and PSGL-1.
- A role for leukocyte-endothelial adhesion mechanisms in epilepsy.
- Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow.
- Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
- CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes.
- Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x.
- Mechanisms for flow-enhanced cell adhesion.
- Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion.
- Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow.
- A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
- Monitoring receptor-ligand interactions between surfaces by thermal fluctuations.
- A catch to integrin activation.
- Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.
- Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.
- Flow-enhanced adhesion regulated by a selectin interdomain hinge.
- Probabilistic modeling of rosette formation.
- Measuring molecular elasticity by atomic force microscope cantilever fluctuations.
- Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice.
- Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells.
- A sulfated address for lymphocyte homing.
- Catch bonds: physical models and biological functions.
- Contributions of Ca2+ to galectin-1-induced exposure of phosphatidylserine on activated neutrophils.
- Force history dependence of receptor-ligand dissociation.
- Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.
- Forces required to initiate membrane tether extrusion from cell surface depend on cell type but not on the surface molecule.
- Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow.
- Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics.
- Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin.
- Catch bonds govern adhesion through L-selectin at threshold shear.
- Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans.
- Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan.
- Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow.
- Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum.
- Dimeric galectin-1 induces surface exposure of phosphatidylserine and phagocytic recognition of leukocytes without inducing apoptosis.
- Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin.
- Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.
- Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
- CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligan...
- P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules.
- N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin.
- Discordant expression of selectin ligands and sialyl Lewis x-related epitopes on murine myeloid cells.
- Glycosulfopeptides with O-glycans containing sialylated and polyfucosylated polylactosamine bind with low affinity to P-selectin.
- Selectins: lectins that initiate cell adhesion under flow.
- Glycosulfopeptides modeled on P-selectin glycoprotein ligand 1 inhibit P-selectin-dependent leukocyte rolling in vivo.
- Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow.
- The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin.
- P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow.
- Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans.
- Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans.
- Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
- Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle.
- Catch bonds: physical models, structural bases, biological function and rheological relevance.
- Characterization of a sialic acid- and P-selectin glycoprotein ligand-1-independent adhesin activity in the granulocytotropic bacterium Anaplasma phagocytophilum.
- Direct observation of catch bonds involving cell-adhesion molecules.
- Selectins: a family of adhesion receptors.
- P-selectin and PSGL-1: exploiting connections between inflammation and venous thrombosis.
- Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation.
- Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow.
- AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells.
- A third specificity-determining site in mu 2 adaptin for sequences upstream of Yxx phi sorting motifs.
- Binding of glycosulfopeptides to P-selectin requires stereospecific contributions of individual tyrosine sulfate and sugar residues.
- Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.
- Leukocyte-leukocyte interactions mediated by platelet microparticles under flow.
- Divergent inducible expression of P-selectin and E-selectin in mice and primates.
- Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin.
- A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin.
- Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein.
- Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1.
- Interactions of the cytoplasmic domain of P-selectin with clathrin-coated pits enhance leukocyte adhesion under flow.
- Endothelial cells in physiology and in the pathophysiology of vascular disorders.
- Tumor necrosis factor-alpha- or lipopolysaccharide-induced expression of the murine P-selectin gene in endothelial cells involves novel kappaB sites and a variant acti...
- Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells.
- Identification of N-terminal residues on P-selectin glycoprotein ligand-1 required for binding to P-selectin.
- A proteasome inhibitor, an antioxidant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-inducible expression of P-selectin in human endothe...
- Role of PSGL-1 binding to selectins in leukocyte recruitment.
- Comparison of tethering and rolling of eosinophils and neutrophils through selectins and P-selectin glycoprotein ligand-1.
- Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils.
- Soluble monomeric P-selectin containing only the lectin and epidermal growth factor domains binds to P-selectin glycoprotein ligand-1 on leukocytes.
- Selectin-carbohydrate interactions during inflammation and metastasis.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Elected Member
Education
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Washington University - Barnes-Jewish Hospital -
University of Chicago Pritzker School of Medicine
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