Associate Professor, Internal Medicine, Washington University School of Medicine

Infectious Disease

Dr. Robyn S. Klein, MD

Robyn Klein practices Infectious Disease. She studied medicine at Albert Einstein College of Medicine of Yeshiva University. Robyn Klein is a published doctor. She published 43 publications, including: 'The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.'

Publications

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.
Viral sensing at the blood-brain barrier: New roles for innate immunity at the CNS vasculature.
TREM2 regulates microglial cell activation in response to demyelination in vivo.
IL-1R1 Signaling Regulates CXCL12-Mediated T Cell Localization and Fate within the Central Nervous System during West Nile Virus Encephalitis.
Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system.
IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis.
Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain ba...
Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS.
CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity.
Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model...
Mediators of oligodendrocyte differentiation during remyelination.
CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity.
The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system.
CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination.
Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis.
IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalom...
Tumor necrosis factor alpha protects against lethal West Nile virus infection by promoting trafficking of mononuclear leukocytes into the central nervous system.
CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis.
Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis.
CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis.
A moving target: the multiple roles of CCR5 in infectious diseases.
CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis.
CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis.
A tumor necrosis factor receptor 1-dependent conversation between central nervous system-specific T cells and the central nervous system is required for inflammatory i...
Detecting axon damage in spinal cord from a mouse model of multiple sclerosis.
Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.
West Nile virus: crossing the blood-brain barrier.
Regulation of neuroinflammation: the role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis.
IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis.
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
Targeting monocyte recruitment in CNS autoimmune disease.
Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone.
Molecular targets for disrupting leukocyte trafficking during multiple sclerosis.
Quantification of increased cellularity during inflammatory demyelination.
TNF-alpha-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis.
The blood-brain barrier, chemokines and multiple sclerosis.
Immunological headgear: antiviral immune responses protect against neuroinvasive West Nile virus.
A genetic basis for human susceptibility to West Nile virus.
Region-specific regulation of inflammation and pathogenesis in experimental autoimmune encephalomyelitis.
Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity.
BDNF stimulates migration of cerebellar granule cells.
Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers.

Schools

Albert Einstein College of Medicine of Yeshiva University
Brigham and Women39s Hospital
Massachusetts General Hospital

Doctors Specialties

Infectious Disease Medicine
Infectious Disease

Accepted Insurances

Education

Massachusetts General Hospital
Brigham and Women's Hospital
Albert Einstein College of Medicine of Yeshiva University

Hospital

Barnes-Jewish Hospital

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