Professor, Medicine, UCSD School of Medicine
Internal Medicine
Dr. Robert Terkeltaub, MD
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Robert Terkeltaub is an expert in the field of Internal Medicine. He received 2 awards: "Fellow" and "Fellow (FACR)". Robert Terkeltaub has written publications. He has 101 publications published with PubMed. The lastest paper is: 'AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages.'
Publications
- Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase.
- AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages.
- Emerging regulators of the inflammatory process in osteoArthritis.
- Apolipoprotein a-I at the interface of vascular inflammation and Arthritis.
- Treatment of acute Gout: A systematic review.
- Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression.
- C/EBP homologous protein drives pro-catabolic responses in chondrocytes.
- Gout: Multinational Gout guidelines: how do we move beyond 'déjàvu'?
- Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes.
- A Delphi Exercise to Identify Characteristic Features of Gout -- Opinions from Patients and Physicians, the First Stage in Developing New Classification Criteria.
- Are cherries now ripe for use as a complementary therapeutic in Gout? Appraisal of the state of evidence.
- Imaging joints for calcium pyrophosphate crystal deposition: a knock to the Knees.
- Rilonacept (interleukin-1 trap) for prevention of Gout flares during initiation of uric acid-lowering therapy: Results from a phase III randomized, double-blind, place...
- Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia.
- RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity.
- The growing array of innate inflammatory ignition switches in osteoArthritis.
- Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.
- Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.
- PseudoGout, hypomagnesemia, and liver transplantation.
- IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation.
- Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.
- Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression.
- One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist.
- Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: new developments relevant to the clinician.
- Parallels between arterial and cartilage calcification: what understanding artery calcification can teach us about chondrocalcinosis.
- Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in...
- Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.
- Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.
- Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice.
- The mutational spectrum of ENPP1 as arising after the analysis of 23 unrelated patients with generalized arterial calcification of infancy (GACI).
- Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage.
- The role of hypertension in cyclosporine-induced hyperuricemia.
- Mediation of spontaneous knee osteoArthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs.
- Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1.
- Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
- Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide...
- Calcium-containing crystals and osteoArthritis: implications for the clinician.
- What do epidemiologic studies tell us about hyperuricemia and cardiovascular Disease and death?
- Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products.
- Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced in...
- Invited review: the mitochondrion in osteoArthritis.
- TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation.
- Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification.
- Evil humors take their toll as innate immunity makes Gouty joints TREM-ble.
- Low vitamin K status is associated with osteoArthritis in the hand and knee.
- Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics.
- The inflammatory process of Gout and its treatment.
- Gout in 2006: the perfect storm.
- Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing OsteoArthritis Study.
- Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.
- Transglutaminase 2 limits murine peritoneal acute Gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
- Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice.
- Hyperuricemia treatment: is creatinine clearance a safer allopurinol dosing meter than plasma creatinine levels?
- Enzyme replacement therapy for murine hypophosphatasia.
- Learning how and when to employ uricase as bridge therapy in refractory Gout.
- Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2.
- Last call for alcohol in Gout?
- Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes.
- Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification.
- Evaluation of an instrument assessing influence of Gout on health-related quality of life.
- Macrophage glucocorticoid receptors join the intercellular dialogue in atherosclerotic lesion calcification.
- Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study.
- Perceptions of Disease and health-related quality of life among patients with gout.
- A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in Gout.
- The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to infla...
- Update on Gout: new therapeutic strategies and options.
- Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy.
- Inorganic pyrophosphatase induces type I collagen in osteoblasts.
- Gout. Novel therapies for treatment of Gout and hyperuricemia.
- Shifting HIFs in osteoArthritis.
- Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4...
- Cartilage cell clusters.
- Gout Study Group: update on hyperuricemia and Gout.
- Serum urate is not associated with coronary artery calcification: the NHLBI Family Heart Study.
- Npp1 promotes atheroSclerosis in ApoE knockout mice.
- Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1? and tumor necrosis factor ?.
- Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.
- Rilonacept (interleukin-1 trap) in the prevention of acute Gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, pla...
- Generalized Arterial Calcification of Infancy and Pseudoxanthoma Elasticum Can Be Caused by Mutations in Either ENPP1 or ABCC6.
- Are either or both hyperuricemia and xanthine oxidase directly toxic to the vasculature? A critical appraisal.
- Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors.
- Minimally important differences of the Gout impact scale in a randomized controlled trial.
- Arterial calcification is driven by RAGE in Enpp1-/- mice.
- Health care utilization in patients with Gout.
- Predictors of doctor-rated and patient-rated Gout severity: Gout impact scales improve assessment.
- Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty Arthritis.
- High versus low dosing of oral colchicine for early acute Gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, ...
- The interleukin 1 inhibitor rilonacept in treatment of chronic gouty Arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind p...
- Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoArthritis severity in the Hartley guinea pig model of knee OA.
- A sugar transporter regulates serum urate levels: implications for prevention and management of hyperuricemia in Gout.
- Colchicine update: 2008.
- Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation.
- Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells.
- Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank mice.
- Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement.
- Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoArthritis.
- New developments in clinically relevant mechanisms and treatment of hyperuricemia.
- Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoArthritis: results of two prospective longitudinal magnetic reson...
- Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.
- Recent developments in diet and Gout.
Schools
University of California At San Diego
Montreal General Hospital
Conditions Treated
- Ankylosing Spondylitis
- Arthritis
- Bursitis
- Carpal Tunnel Syndrome
- View All
Doctors Specialties
- Geriatric Medicine
- Rheumatology
- Internal Medicine
Accepted Insurances
Awards
- Fellow
- Fellow (FACR)
Education
-
Scripps Clinic -
McGill University Faculty of Medicine
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