Regents Professor, Medicine, University of Minnesota Medical School
Internal Medicine
Dr. Robert P. Hebbel, MD
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Robert Hebbel is an expert in the field of Internal Medicine. He attended University of Minnesota Medical School. University of Minnesota Medical School is ranked 40/10 in Research/PrimaryCare. He has 1 awards "Elected Member". Robert Hebbel is a published doctor. He published 101 publications, including: 'Iron compartments associated with sickle RBC membranes: a mechanism for the targeting of oxidative damage.'
Publications
- Sickle cell disease: renal manifestations and mechanisms.
- Ischemia-reperfusion Injury in Sickle Cell Anemia: Relationship to Acute Chest Syndrome, Endothelial Dysfunction, Arterial Vasculopathy, and Inflammatory Pain.
- Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery.
- Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.
- Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.
- Pilot study of vascular health in survivors of osteosarcoma.
- Age sensitizes the kidney to heme protein-induced acute kidney injury.
- Morphine promotes renal pathology in sickle mice.
- Pilot study of vascular health in survivors of Hodgkin lymphoma.
- Carbon-fiber microelectrode amperometry reveals sickle cell-induced inflammation and chronic morphine effects on single mast cells.
- Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness.
- Regional and Systemic Hemodynamic Responses Following the Creation of a Murine Arteriovenous Fistula.
- Shear Stress Responses of Adult Blood Outgrowth Endothelial Cells Seeded on Bioartificial Tissue.
- Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.
- Selective enhancement of contractions to α1-adrenergic receptor activation in the aorta of mice with sickle cell disease.
- Reconstructing sickle cell disease: a data-based analysis of the "hyperhemolysis paradigm" for pulmonary hypertension from the perspective of evidence-based ...
- Erythroid-Specific Expression of ?-globin from Sleeping Beauty-Transduced Human Hematopoietic Progenitor Cells.
- Circulating activated endothelial cells in pediatric obesity.
- Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
- Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
- Nuclear factor-kappa B (NFkappaB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for t...
- Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease.
- The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.
- Proinflammatory phenotype with imbalance of KLF2 and RelA: risk of childhood stroke with sickle cell anemia.
- Endothelial nitric oxide synthase and nitric oxide regulate endothelial tissue factor expression in vivo in the sickle transgenic mouse.
- Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease.
- Cell adhesion molecule 1: a novel risk factor for venous thrombosis.
- Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions.
- The systems biology-based argument for taking a bold step in chemoprophylaxis of sickle vasculopathy.
- Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice.
- Blood outgrowth endothelial cell migration and trapping in vivo: a window into gene therapy.
- Core2 1-6-N-glucosaminyltransferase-I is crucial for the formation of atherosclerotic lesions in apolipoprotein E-deficient mice.
- Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors.
- Genetic endothelial systems biology of sickle stroke risk.
- Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases.
- Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors.
- The establishment of murine blood outgrowth endothelial cells and observations relevant to gene therapy.
- Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
- Blood outgrowth endothelial cells as a vehicle for transgene expression of hepatocyte-secreted proteins via Sleeping Beauty.
- Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.
- Protective effect of arginine on oxidative stress in transgenic sickle mouse models.
- Robust vascular protective effect of hydroxamic acid derivatives in a sickle mouse model of inflammation.
- Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease.
- Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor.
- Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction.
- Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice.
- Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice.
- Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice.
- Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury.
- Polynitroxyl albumin inhibits inflammation and vasoocclusion in transgenic sickle mice.
- Opioids heal ischemic wounds in the rat.
- Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion.
- Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy.
- Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.
- Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin.
- Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice.
- Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia.
- Differential expression of E- and P-selectin in the microvasculature of sickle cell transgenic mice.
- Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice.
- Special issue of Microcirculation: examination of the vascular pathobiology of sickle cell anemia. Foreword.
- The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy.
- Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice.
- Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes.
- Transgenic sickle mice have vascular inflammation.
- Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis.
- Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.
- Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth.
- Use of blood outgrowth endothelial cells for gene therapy for hemophilia A.
- H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.
- Activation of endothelial and coagulation systems in left ventricular assist device recipients.
- Circulating endothelial cells in pulmonary hypertension.
- Sickle hemoglobin instability: a mechanism for malarial protection.
- Circulating endothelial cells. Biomarker of vascular disease.
- Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions.
- Semi-supervised learning via penalized mixture model with application to microarray sample classification.
- A practical question based on cross-platform microarray data normalization: are BOEC more like large vessel or microvascular endothelial cells or neither of them?
- CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane.
- The dynamic regulation of microcirculatory conduit function: features relevant to transfusion medicine.
- A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsis.
- Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells.
- Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo.
- Improved microvascular network in vitro by human blood outgrowth endothelial cells relative to vessel-derived endothelial cells.
- Adhesion of sickle red cells to endothelium: myths and future directions.
- Blood outgrowth endothelial cell-based systemic delivery of antiangiogenic gene therapy for solid tumors.
- Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis.
- Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancer.
- Systemic inhibition of tumour angiogenesis by endothelial cell-based gene therapy.
- Measuring circulating cell-derived microparticles.
- The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro.
- Iron compartments associated with sickle RBC membranes: a mechanism for the targeting of oxidative damage.
- Identification and functional assessment of endothelial P1H12.
- NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases.
- Oxidation-induced changes in microrheologic properties of the red blood cell membrane.
- Synergistic effects of oxidation and deformation on erythrocyte monovalent cation leak.
- Lipid hydroperoxides permit deformation-dependent leak of monovalent cation from erythrocytes.
- Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology.
- Reversible deformation-dependent erythrocyte cation leak. Extreme sensitivity conferred by minimal peroxidation.
- Monozygotic twins with sickle cell anemia and discordant clinical courses: clinical and laboratory studies.
- Hydroxyl radical formation by sickle erythrocyte membranes: role of pathologic iron deposits and cytoplasmic reducing agents.
- Nucleosomal histone protein protects DNA from iron-mediated damage.
Schools
University Of Minnesota Medical School
Fairview University Med Center
University Wa Med Center
Doctors Specialties
- Hematology
- Oncology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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University of Minnesota at Fairview -
University of Washington -
University of Minnesota Medical School
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