Physician
Rheumatology
Dr. Robert M. Plenge, MD
Robert Plenge practices Rheumatology. He graduated from Case Western Reserve University School of Medicine. He received 2 awards: "Elected Member" and "Fellow". Robert Plenge is a published doctor. He published 82 publications, including: 'Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.'
Publications
- Accuracy of the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) As a Research Tool for Identification of Patients with Uveit...
- Lack of gene-diuretic interactions on the risk of incident gout: the Nurses' Health Study and Health Professionals Follow-up Study.
- Genomic architecture of pharmacological efficacy and adverse events.
- HLA-DRB1-Associated Rheumatoid Arthritis Risk at Multiple Levels in African Americans: Hierarchical Classification Systems, Amino Acid Positions, and Residues.
- Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.
- A role for noncoding variation in schizophrenia.
- (Epi)Genetic Analyses of Age-Related Macular Degeneration: Case-Control and Discordant Twin Studies.
- Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity.
- Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
- Identification of secreted phosphoprotein 1 gene as a new rheumatoid Arthritis susceptibility gene.
- Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid Arthritis: recent findings and challenges.
- The influence of polygenic risk scores on heritability of anti-CCP level in RA.
- Quantifying Missing Heritability at Known GWAS Loci.
- Genetics of rheumatoid Arthritis contributes to biology and drug discovery.
- Lipid and lipoprotein levels and trend in rheumatoid Arthritis compared to the general population.
- Validating therapeutic targets through human genetics.
- Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn's Disease.
- Association between low density lipoprotein and rheumatoid Arthritis genetic factors with low density lipoprotein levels in rheumatoid Arthritis and non-rheumatoid art...
- Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
- Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway.
- Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.
- Improving Case Definition of Crohn's Disease and Ulcerative Colitis in Electronic Medical Records Using Natural Language Processing: A Novel Informatics Approach.
- Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis.
- PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid Arthritis.
- Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid Arthritis cases and non-rheumatoid ar...
- Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
- Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease.
- Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid Arthritis.
- Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis.
- Informed conditioning on clinical covariates increases power in case-control association studies.
- Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease.
- Bayesian inference analyses of the polygenic architecture of rheumatoid Arthritis.
- Genomic technology applied to pharmacological traits.
- Recommendations for publication of genetic association studies in Arthritis & rheumatism.
- Personalized medicine in rheumatoid Arthritis: miles to go before we sleep.
- Meta-analysis of genome-wide association studies in celiac disease and rheumatoid Arthritis identifies fourteen non-HLA shared loci.
- Genetic basis of autoantibody positive and negative rheumatoid Arthritis risk in a multi-ethnic cohort derived from electronic health records.
- Genetic risk score predicting risk of rheumatoid Arthritis phenotypes and age of symptom onset.
- Most common single-nucleotide polymorphisms associated with rheumatoid Arthritis in persons of European ancestry confer risk of rheumatoid Arthritis in African Americans.
- Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue Syndrome or chronic immunomodulatory conditions.
- Most common SNPs associated with rheumatoid Arthritis in subjects of European ancestry confer risk of rheumatoid Arthritis in African-Americans.
- Electronic medical records for discovery research in rheumatoid Arthritis.
- Rheumatoid Arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
- Leveraging human genetics to develop future therapeutic strategies in rheumatoid Arthritis.
- Unlocking the pathogenesis of celiac disease.
- Rheumatoid Arthritis genetics: 2009 update.
- De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
- REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid Arthritis.
- The PRL -1149 G/T polymorphism and rheumatoid Arthritis susceptibility.
- Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid Arthritis.
- Recent progress in rheumatoid Arthritis genetics: one step towards improved patient care.
- Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid Arthritis.
- The chromosome 7q region association with rheumatoid Arthritis in females in a British population is not replicated in a North American case-control series.
- Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid Arthritis in the exten...
- Shared genetic risk factors for type 1 diabetes and celiac disease.
- Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
- Common variants at CD40 and other loci confer risk of rheumatoid Arthritis.
- Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
- Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid Arthritis.
- A novel polymorphism of the human CD40 receptor with enhanced function.
- A broad analysis of IL1 polymorphism and rheumatoid Arthritis.
- Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
- Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid Arthritis, independent of the DRB1 locus.
- Defining the role of the MHC in autoimmunity: a review and pooled analysis.
- Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid Arthritis: current challenges and future directions.
- Analysis and application of European genetic substructure using 300 K SNP information.
- Two independent alleles at 6q23 associated with risk of rheumatoid Arthritis.
- TRAF1-C5 as a risk locus for rheumatoid Arthritis--a genomewide study.
- STAT4 and the risk of rheumatoid Arthritis and systemic lupus erythematosus.
- Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
- X chromosome-inactivation patterns of 1,005 phenotypically unaffected females.
- Principal components analysis corrects for stratification in genome-wide association studies.
- Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia.
- Replication of putative candidate-gene associations with rheumatoid Arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN2...
- An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse.
- Skewed X-chromosome inactivation is a common feature of X-linked mental retardation disorders.
- Autosomal dominant mutations affecting X inactivation choice in the mouse.
- Allele-specific methylation occurs at genetic variants associated with complex disease.
- Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.
- Modeling disease severity in multiple sclerosis using electronic health records.
- Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.
Schools
Case Western Reserve University School of Medicine
University Ca Sf School Of Med
Procedures Preformed
- Joint Drainage
Conditions Treated
- Adhesive Capsulitis
- Arthritis
- OsteoArthritis
- OsteoArthritis of Hand or Wrist
- View All
Doctors Specialties
- Rheumatology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Medicare Advantage PFFS
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
- Fellow
Education
-
Brigham and Women's Hospital -
UCSF -
Case Western Reserve University School of Medicine
Hospital
-
Brigham and Women's Faulkner Hospital -
Brigham and Women's Hospital
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