Physician
Neurology
Dr. Robert L. Knobler, MD
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Robert L. Knobler, MD works in the field of Neurology. He attended State University of New York Downstate Medical Center College of Medicine. Robert Knobler is a published doctor. He published 101 publications, including: 'Modulation of T cell-endothelial adhesion by astrocyte conditioned medium.'
Publications
- Extracorporeal photopheresis as second-line treatment for acute graft-versus-host Disease: impact on six-month freedom from treatment failure.
- Epidermal Elafin Expression is an Indicator of Poor Prognosis in Cutaneous Graft-versus-Host Disease.
- Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid refractory acute GVHD: A multicenter comparative analysis.
- Utililization of experimental animal model for correlative multispectral MRI and pathological analysis of brain tumors.
- Modulation of T cell-endothelial adhesion by astrocyte conditioned medium.
- Improved intracranial lesion characterization by tissue segmentation based on a 3D feature map.
- A multicenter, randomized, double-blind, placebo-controlled trial of influenza immunization in Multiple sclerosis.
- Formation of undifferentiated mesenteric tumors in transgenic mice expressing human neurotropic polymavirus early protein.
- Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters.
- Junctional region of the myelin basic protein-specific T cell receptor beta chain in mice.
- Regulation of myelin basic protein gene transcription: identification of a distal cis-acting regulatory element.
- Organ specific endothelial cell heterogeneity influences differential replication and cytopathogenicity of MHV-3 and MHV-4. Implications in viral tropism.
- Expression of the myelin basic protein gene in transgenic mice expressing human neurotropic virus, JCV, early protein.
- Preferential but not exclusive T cell receptor V beta chain utilization of myelin basic protein and peptide-specific T cell clones in mice.
- Distribution of the blood-brain barrier in heterotopic brain transplants and its relationship to the lesions of EAE.
- Crohn's Disease in a patient with multiple sclerosis.
- Interleukin-2 blocks oligodendrocyte progenitor proliferation.
- Genetic regulation of susceptibility and severity of demyelination.
- Neuroendocrine regulation of immune parameters. Photoperiod control of the spleen in Syrian hamsters.
- Brain transplantation in genetic analysis of experimental allergic encephalomyelitis.
- Immune effects of intracerebral infection with mouse hepatitis virus.
- Intracerebral beta-interferon in brain tumor therapy. Monitoring cerebral function with compressed spectral analysis.
- Down-regulation of gamma-interferon-induced class II expression of human glioma cells by recombinant beta-interferon.
- Proportions of immature CD19+CD21- B lymphocytes predict the response to extracorporeal photopheresis in patients with chronic graft-versus-host Disease.
- Differential effect of 8-methoxypsoralen, 4,6,4''-trimethylangelicin, and chlorpromazine on cell death and TNF-alpha production.
- UVA activated 8-MOP and chlorpromazine inhibit release of TNF-alpha by post-transcriptional regulation.
- Measuring therapeutic response in chronic graft-versus-host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chr...
- Extracorporeal photopheresis: past, present, and future.
- Defining early mycosis fungoides.
- Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organizatio...
- Heparin-induced thrombocytopenia: a complication in extracorporeal photochemotherapy (photopheresis).
- Total skin electron radiation in the management of mycosis fungoides: Consensus of the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lym...
- Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes.
- A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host Disease.
- Extracorporeal photopheresis for the treatment of refractory Crohn''s Disease: results of an open-label pilot study.
- Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients.
- Definition of TCR epitopes for CTL-mediated attack of cutaneous T cell lymphoma.
- Ibuprofen treatment versus gradual introduction of interferon beta-1b in patients with MS.
- Cutaneous ulcerations and pustular psoriasis flare caused by recombinant interferon beta injections in patients with Multiple sclerosis.
- Reflex sympathetic dystrophy: occurrence of chronic edema and nonimmune bullous skin lesions.
- Interleukin-6 induction in vitro in mouse brain endothelial cells and astrocytes by exposure to mouse hepatitis virus (MHV-4, JHM).
- Systemic recombinant human interferon-beta treatment of relapsing-remitting Multiple sclerosis: pilot study analysis and six-year follow-up.
- Cytokine induction in vitro in mouse brain endothelial cells and astrocytes by exposure to mouse hepatitis virus (MHV-4, JHM).
- Interferon-gamma-inducible endothelial cell class II major histocompatibility complex expression correlates with strain- and site-specific susceptibility to experiment...
- Distributional patterns of Multiple sclerosis brain lesions. Magnetic resonance imaging--clinical correlation.
- Regulation of the expression of intercellular adhesion molecule-1 (ICAM-1) and the putative adhesion molecule Basigin on murine cerebral endothelial cells by MHV-4 (JHM).
- Reflex sympathetic dystrophy revisited: MR imaging findings before and after infusion of contrast material.
- Generation of an anti-mouse brain endothelial cell monoclonal antibody that recognizes 84-110 kDa and 36 kDa determinants that are upregulated by cytokines.
- Effects of staphylococcal enterotoxin B on T cell receptor V beta utilization and clinical manifestations of experimental allergic encephalomyelitis.
- T cell receptor V beta gene utilization in myelin basic protein specific clones from CXJ1 recombinant inbred mice.
- Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis.
- Inverse ocular bobbing.
- Acute and persistent viral infections of differentiated Nerve cells.
- A neurologic rating scale (NRS) for use in Multiple sclerosis.
- Clinical trial of natural alpha interferon in Multiple sclerosis.
- Systemic alpha-interferon therapy of Multiple sclerosis.
- Virologic models of chronic relapsing demyelinating Disease.
- Peripheral neuropathy in the Twitcher mutant. A new experimental model of endoneurial edema.
- Mouse hepatitis virus type 4 infection of primary glial cultures from genetically susceptible and resistant mice.
- In vivo and in vitro models of demyelinating Diseases. V. Comparison of the assembly of mouse hepatitis virus, strain JHM, in two murine cell lines.
- Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS Diseases. Pathobiology of Disease induced by wild type and mutants ts8 and ts15 in B...
- Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4.
- Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell--cell fusion.
- Host and virus factors associated with CNS cellular tropism leading to encephalomyelitis or demyelination induced by the JHM strain of mouse hepatitis virus.
- Selective localization of wild type and mutant mouse hepatitis virus (JHM strain) antigens in CNS tissue by fluorescence, light and electron microscopy.
- Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system Disease. I. genetic control and murine neuron as the susceptible site of Disease.
- The failure of monoclonal antibody-defined lymphocyte subsets to monitor Disease activity in patients with multiple sclerosis.
- Disease activity markers in multiple sclerosis. Another look at suppressor cells defined by monoclonal antibodies OKT4, OKT5, and OKT8.
- Western and dot immunoblotting analysis of viral antigens and antibodies: application to murine hepatitis virus.
- Murine hepatitis virus-4 (strain JHM)-induced neurologic Disease is modulated in vivo by monoclonal antibody.
- Topographical mapping of epitopes on the glycoproteins of murine hepatitis virus-4 (strain JHM): correlation with biological activities.
- Host genetic control of mouse hepatitis virus type-4 (JHM strain) replication. II. The gene locus for susceptibility is linked to the Svp-2 locus on mouse chromosome 7.
- Host genetic control of mouse hepatitis virus type 4 (JHM strain) replication. I. Restriction of virus amplification and spread in macrophages from resistant mice.
- Bidirectionality in the tongue processes of the oligoendroglial cell investment of axons in the albino rat.
- A simple technique to improve contrast of low-contrast electron micrographs.
- Serial section analysis of myelin development in the central nervous system of the alino rat: an electron microscopical study of early axonal ensheathment.
- Oligodendroglial ensheathment of axons during myelination in the developing rat central nervous system. A serial section electron microscopical sttudy.
- Heterotopic brain transplants in the study of experimental allergic encephalomyelitis.
- Suppression of acute and relapsing experimental allergic encephalomyelitis with mitoxantrone.
- Relapsing experimental allergic encephalomyelitis in radiation bone marrow chimeras between high and low susceptible strains of mice.
- Neuroimmunology: modulation of the hamster immune system by photoperiod.
- Trigeminal neuralgia in a patient with multiple sclerosis treated with high Cervical spinal cord stimulation. Case report.
- Systemic interferon therapy of Multiple sclerosis: the pros.
- Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro.
- Reduced S-adenosylmethionine:protein-lysine N-methyltransferase activity (protein methylase III) in shiverer mutant mouse brain.
- Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating Disease. I. Differences between susceptible SJ...
- Down-regulation of interferon-gamma-induced class II expression on human glioma cells by recombinant interferon-beta: effects of dosage treatment schedule.
- Infection and involution of mouse thymus by MHV-4.
- Differential effects of MHV-4 infection of astrocytes and oligodendrocytes in vitro.
- Host genetic regulation of acute MHV-4 viral encephalomyelitis and acute experimental autoimmune encephalomyelitis in (BALB/cKe x SJL/J) recombinant-inbred mice.
- Epitope-specific antibody response to murine hepatitis virus-4 (strain JHM).
- Differential modulation of MHC class I antigen expression on mouse brain endothelial cells by MHV-4 infection.
- Antibodies to GM1 and GD1b in patients with motor neuron Disease without plasma cell dyscrasia.
- Myelin basic protein-specific protein methylase I activity in shiverer mutant mouse brain.
- Immunological complications in Multiple sclerosis patients receiving interferon.
- Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.
- Regulation of MHC class I and II antigens on cerebral endothelial cells and astrocytes following MHV-4 infection.
- Is the 110K glycoprotein the only receptor for MHV and does its expression determine species specificity?
- Lower extremity motor evoked potentials in Multiple sclerosis.
- Reflex sympathetic dystrophy. Occurrence of inflammatory skin lesions in patients with stages II and III Disease.
Schools
SUNY Dwnstate M C Coll Med
Downstate SUNY Med Ctr
Scripps Clin Rsch Fdn
City college of New York
Conditions Treated
- Autonomic Disorders
- Brachial Plexus Injuries
- Brachial Plexus Palsy
- Cervical Radiculopathy
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Doctors Specialties
- Neurology
Accepted Insurances
Education
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SUNY Health Science Center at Brooklyn -
State University of New York Downstate Medical Center College of Medicine
Hospital
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Thomas Jefferson University Hospital
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