Physician

Oncology

Dr. Robert J. Lechleider, MD

Robert J. Lechleider, MD practices Oncology. He went to University of Illinois College of Medicine. Robert J. Lechleider is a published doctor and has 49 publications published. The lastest was: 'SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.'

Publications

Phase 1, open-label study of MEDI-547 in patients with relapsed or refractory solid tumors.
Circulating tumor cells: application as a biomarker for molecular characterization and predictor of survival in an all-comer solid tumor phase I clinical study.
A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
CD22 as a target for cancer therapy.
Thrombotic Microangiopathy with Targeted Cancer Agents.
Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an ...
Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies.
Transforming growth factor-beta receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?
Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src.
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.
Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta.
RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation.
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.
Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell line.
Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta.
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.
Conditional knockout of the Smad1 gene.
Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion.
Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner.
Hormesis and the law.
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
Selective loss of the transforming growth factor-beta apoptotic signaling pathway in mutant NRP-154 rat prostatic epithelial cells.
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.
Functional analysis of human Smad1: role of the amino-terminal domain.
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta.
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.
Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta.
Characterization of functional domains within Smad4/DPC4.
The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.
Retinoids increase cell-cell adhesion strength, beta-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: a role for serine k...
Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2.
Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2.
SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and i...
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
SH2 domains recognize specific phosphopeptide sequences.
Mechanism of proton-induced bone calcium release: calcium carbonate-dissolution.
Transcriptional control of expression of the TGF-betas.
Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.
Multiple forms of TGF-beta: distinct promoters and differential expression.
Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.
Identification and characterization of the chicken transforming growth factor-beta 3 promoter.

Schools

University of Illinois At Chicago College of Medicine

Doctors Specialties

Medical Oncology
Oncology

Accepted Insurances

Education

Beth Israel Deaconess Medical Center
University of Illinois College of Medicine

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