Physician
Pathology
Dr. Robert J. Konrad, MD
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Dr. Robert J. Konrad practices Pathology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. Robert Konrad is a published doctor as well. He has 91 publications published. The latest was: Glucose-induced tyrosine phosphorylation of p125 in beta cells and pancreatic islets. A novel proximal signal in insulin secretion.
Publications
- Evaluation of immunogenicity of LY2963016 insulin glargine compared with Lantus® insulin glargine in patients with type 1 or type 2 diabetes mellitus.
- Low Incidence of Anti-Drug Antibodies in Type 2 Diabetes Patients Treated with Once Weekly GLP-1 Receptor Agonist Dulaglutide.
- Affinity capture elution bridging assay: A novel immunoassay format for detection of anti-therapeutic protein antibodies.
- The Effect of Discontinuing Treatment with Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women with Low Bone Mineral Density.
- Novel sandwich immunoassays for the measurement of total and active FGF21.
- PCSK9 is Present in Human Cerebrospinal Fluid and is Maintained at Remarkably Constant Concentrations Throughout the Course of the Day.
- Hepcidin-25 concentrations are markedly increased in patients with chronic kidney disease and are inversely correlated with estimated glomerular filtration rates.
- Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry.
- Serum hepcidin levels are associated with obesity but not liver disease.
- Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia.
- A novel high-sensitivity electrochemiluminescence (ECL) sandwich immunoassay for the specific quantitative measurement of plasma glucagon.
- Determination of Cathepsin S Abundance and Activity in Human Plasma and Implications for Clinical Investigation.
- Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration.
- Glycerolipid acyltransferases in triglyceride metabolism and energy homeostasis-potential as drug targets.
- Development of a novel radioimmunoassay to detect autoantibodies to amyloid beta peptides in the presence of a cross-reactive therapeutic antibody.
- Validation of ELISA Methods for Quantification of Total Tau and Phosporylated-Tau181 in Human Cerebrospinal Fluid with Measurement in Specimens from Two Alzheimer's Di...
- Plasma proprotein convertase subtilisin kexin type 9 is a heritable trait of familial combined hyperlipidemia.
- Dual-Monoclonal, Sandwich Immunoassay Specific for Glucose-Dependent Insulinotropic Peptide1-42, the Active Form of the Incretin Hormone.
- Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.
- A dual-monoclonal sandwich ELISA specific for hepcidin-25.
- High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol.
- Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels.
- Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9.
- The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.
- Longitudinal studies of cardiac troponin-I concentrations in serum from male Sprague Dawley rats: baseline reference ranges and effects of handling and placebo dosing ...
- Peroxisome proliferator-activated receptor alpha agonists regulate cholesterol ester transfer protein.
- Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.
- AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
- A novel splicing variant of proprotein convertase subtilisin/kexin type 9.
- Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.
- An apolipoprotein A-I mimetic dose-dependently increases the formation of prebeta1 HDL in human plasma.
- Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice.
- Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9.
- Ultrasensitive cross-species measurement of cardiac troponin-I using the Erenna immunoassay system.
- Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA.
- Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol.
- Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis.
- Alloxan is an inhibitor of O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.
- Definitive N-terminal protein sequence and further characterization of the novel apolipoprotein A5 in human serum.
- Administration of a PPARalpha agonist increases serum apolipoprotein A-V levels and the apolipoprotein A-V/apolipoprotein C-III ratio.
- A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.
- The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other ap...
- Glucose stimulates the association of Crk with p130Cas in pancreatic beta cells.
- Glucose stimulates the tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells.
- Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.
- Comparison of non-diglyceride- and diglyceride-based assays for pancreatic lipase activity.
- Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung.
- Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus.
- Inhibition of phospholipase A2 and insulin secretion in pancreatic islets.
- Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets.
- Brief report: myeloma-associated paraprotein directed against the HIV-1 p24 antigen in an HIV-1-seropositive patient.
- Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells.
- Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglyc...
- The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.
- Glucose and carbachol synergistically stimulate phosphatidic acid accumulation in pancreatic islets.
- The role of apolipoprotein A5 in non-alcoholic fatty liver disease.
- Fuel secretagogue stimulation of arachidonic acid accumulation in fresh and cultured pancreatic islets.
- Detection of ketosis in vitreous at autopsy after embalming.
- An unusual multiple drug intoxication case involving citalopram.
- Postmortem diagnosis of unsuspected diabetes mellitus established by determination of decedent's hemoglobin A1c level.
- Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase.
- Glucose-induced tyrosine phosphorylation of p125 in beta cells and pancreatic islets. A novel proximal signal in insulin secretion.
- Automated chemiluminescent assay for C-peptide.
- Evaluation of a fully automated high-performance liquid chromatography assay for hemoglobin A1c.
- The influence of matrix type, diurnal rhythm and sample collection and processing on the measurement of plasma beta-amyloid isoforms using the INNO-BIA plasma Abeta fo...
- New automated chemiluminescent assay for erythropoietin.
- Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship wit...
- Development and validation of a phosphorylated SMAD ex vivo stimulation assay.
- Purification of the O-glycosylated protein p135 and identification as O-GlcNAc transferase.
- The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.
- A modified method of islet isolation preserves the ability of pancreatic islets to increase protein O-glycosylation in response to glucose and streptozotocin.
- Glucose and streptozotocin stimulate p135 O-glycosylation in pancreatic islets.
- Evaluation of a homogeneous direct LDL-cholesterol assay in diabetic patients: effect of glycemic control.
- The role of O-linked protein glycosylation in beta-cell dysfunction.
- Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion.
- Optimization of analytical and pre-analytical variables associated with an ex vivo cytokine secretion assay.
- Differential reactivity of anti-primate and anti-human secondary antibodies against human and monkey immunoglobulins: implications for determining the sensitivity of i...
- Effect of double antigen bridging immunoassay format on antigen coating concentration dependence and implications for designing immunogenicity assays for monoclonal an...
- The diabetogenic antibiotic streptozotocin modifies the tryptic digest pattern for peptides of the enzyme O-GlcNAc-selective N-acetyl-beta-d-glucosaminidase that conta...
- Relationship of apolipoprotein A5 and apolipoprotein C3 levels to serum triglycerides in patients with type 2 diabetes.
- An Affinity Capture Elution (ACE) assay for detection of anti-drug antibody to monoclonal antibody therapeutics in the presence of high levels of drug.
- The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells.
- A novel method for quantitative measurement of a biomarker in the presence of a therapeutic monoclonal antibody directed against the biomarker.
- Development of a novel sandwich ELISA for measuring cell lysate ABCA1 protein levels.
- The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in rats.
- Comparison of assay formats for drug-tolerant immunogenicity testing.
- Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population.
- Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents.
- Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease.
- A novel, high-sensitivity and drug-tolerant sandwich immunoassay for the quantitative measurement of circulating proteins.
Schools
Perelman School of Medicine University of Pennsylvania
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Education
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University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
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