Associate Professor, Medicine, Perelman School of Medicine
Oncology
Dr. Robert H. Vonderheide, MD
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Robert Vonderheide practices Oncology. He attended Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School has a rank of 1 in research and a 12 in primary care He received awards:"Elected Member". Robert Vonderheide is also a published doctor. He has 72 paper published. The most recent paper is: Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.
Publications
- Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.
- Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in Cancer.
- NKG2D expression by CD8+ T-cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT.
- Awakening the immune system with radiation: Optimal dose and fractionation.
- Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.
- Immune Activation and a 9-Year Ongoing Complete Remission Following CD40 Antibody Therapy and Metastasectomy in a Patient with Metastatic Melanoma.
- Tumor-promoting inflammatory networks in pancreatic neoplasia: another reason to loathe kras.
- CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice.
- Mitigating the toxic effects of antiCancer immunotherapy.
- Engineering T cells for Cancer: our synthetic future.
- Role of crosslinking for agonistic CD40 monoclonal antibodies as immune therapy of Cancer.
- Dynamic Interplay of Oncogenes and T Cells Induces PD-L1 in the Tumor Microenvironment.
- A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma.
- Immunotherapy at Large: The road to personalized Cancer vaccines.
- CD40 Therapy and Surgery: A Potential Immunologic Partnership.
- Cracking the stone: combination vaccination and ctla-4 blockade in pancreatic Cancer.
- CD40 immunotherapy for pancreatic Cancer.
- Agonistic CD40 Antibodies and Cancer Therapy.
- Inflammatory networks and immune surveillance of pancreatic carcinoma.
- Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors.
- Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease.
- Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic Cancer.
- CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients.
- Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian Cancer in first or second remi...
- Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population.
- Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene.
- CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans.
- Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.
- Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity...
- CD40-Activated B Cell Cancer Vaccine Improves Second Clinical Remission and Survival in Privately Owned Dogs with Non-Hodgkin's Lymphoma.
- Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors.
- Tremelimumab in combination with exemestane in patients with advanced Breast cancer and treatment-associated modulation of inducible costimulator expression on patient...
- Regulatory T cells: overcoming suppression of T-cell immunity.
- A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and metastatic pleural effusions.
- Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.
- Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.
- Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells.
- Functional unresponsiveness and replicative senescence of myeloid leukemia antigen-specific CD8+ T cells after allogeneic stem cell transplantation.
- Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.
- Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other Cancers.
- Survivin as a universal tumor antigen for novel Cancer immunotherapy: functions of a killer clone.
- Differential lysis of tumors by polyclonal T cell lines and T cell clones specific for hTERT.
- Telomerase-specific T-cell immunity in Breast cancer: effect of vaccination on tumor immunosurveillance.
- Dynamics of the immune reaction to pancreatic Cancer from inception to invasion.
- Universal tumor antigens for Cancer vaccination: targeting telomerase for immunoprevention.
- A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor...
- Anti-CD40 agonist antibodies: preclinical and clinical experience.
- Shared MHC class II-dependent Melanoma ribosomal protein L8 identified by phage display.
- Clinical activity and immune modulation in Cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.
- Prospect of targeting the CD40 pathway for Cancer therapy.
- Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.
- Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma.
- Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation.
- Cancer-testis antigens in tumor biology and immunotherapy.
- Getting to the surface: a link between tumor antigen discovery and natural presentation of peptide-MHC complexes.
- Regulatory T cells and cytokines in malignant pleural effusions Secondary to mesothelioma and carcinoma.
- RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy.
- High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy.
- Vaccination of Cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
- The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.
- Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell t...
- Targeting adult and pediatric Cancers via cell-based vaccines and the prospect of activated B lymphocytes as a novel modality.
- Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction.
- A translational bridge to Cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cell immunotherapy.
- HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy.
- Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinica...
- Cellular Composition of the Tumor Microenvironment.
- Methods for Analysis of the Immune System in Mouse Cancer Models.
- Multicolor Flow Cytometric Analysis of Immune Cell Subsets in Tumor-Bearing Mice.
- Immunohistochemical assessment of immune cells in mouse tumor tissue.
- A myeloid-derived suppressor cell-mediated T-cell suppression assay for functional evaluation of immune cells in tumor-bearing mice.
Schools
Harvard Medical School
Mass Gen Hospital
Dana Farber Canc Institute
Procedures Preformed
- Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
Conditions Treated
- Breast Cancer
- Lung Cancer
- Melanoma
- Secondary Malignancies
- View All
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Blue Card PPO
- Coventry Health America PPO
- Coventry Health Care of Delaware PPO
- First Health (Coventry Health Care) PPO
- Geisinger Health Plan
- Community Blue PPO
- Direct Access
- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
- Horizon Blue Cross Blue Shield PPO
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
Awards
- Elected Member
Education
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Brigham and Women's Hospital -
Massachusetts General Hospital -
Harvard Medical School
Hospital
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Philadelphia Veterans Affairs Medical Center -
Hospital of the University of Pennsylvania
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