Associate Professor, Biochemistry and Molecular Biology, University of New Mexico School of Medicine
Pathology
Dr. Robert A. Orlando II, MD
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Dr. Robert A. Orlando II is an expert in the field of Pathology. He graduated from Rutgers New Jersey Medical School. Rutgers New Jersey Medical School has a rank of 76 in research and a 0 in primary care He received awards:"Top MD". Robert Orlando is a published doctor as well. He has 50 publications published. The latest was: Megalin is an endocytic receptor for insulin. He accepts Medicare.
Publications
- Prevention of skin carcinogenesis by the β-blocker carvedilol.
- The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.
- Curcumin Reduces Cytotoxicity of 5-Fluorouracil Treatment in Human Breast Cancer Cells.
- The genetics of childhood obesity and interaction with dietary macronutrients.
- SPION-Enhanced Magnetic Resonance Imaging of Alzheimer's Disease Plaques in A?PP/PS-1 Transgenic Mouse Brain.
- Increased CD36 expression signals monocyte activation among patients with type 2 diabetes.
- Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.
- Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription ...
- Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells.
- The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient f...
- Bioengineered implantation of megalin-expressing cells: a potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure.
- The low density lipoprotein receptor-related protein complexes with cell surface heparan sulfate proteoglycans to regulate proteoglycan-mediated lipoprotein catabolism.
- GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function.
- Molecular signatures in the prevention of radiation damage by the synergistic effect of N-acetyl cysteine and qingre liyan decoction, a traditional chinese medicine, u...
- DMH1, a Small Molecule Inhibitor of BMP Type I Receptors, Suppresses Growth and Invasion of Lung Cancer.
- Crosstalk between Immune Cells and Adipocytes Requires Both Paracrine Factors and Cell Contact to Modify Cytokine Secretion.
- Regulation of pyruvate kinase expression and growth in mastocytoma cells. I. Initial observations.
- Protease nexin-1 expression is altered in human breast cancer.
- Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).
- Identification of a pathogenic epitope involved in initiation of Heymann nephritis.
- Development of a Mammalian suspension culture for expression of active recombinant human urokinase-type plasminogen activator.
- Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells.
- Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.
- Induction of passive Heymann nephritis with antibodies specific for a synthetic peptide derived from the receptor-associated protein.
- Functional domains of the receptor-associated protein (RAP).
- gp330 and RAP: the Heymann nephritis antigenic complex.
- The expression of megalin (gp330) and LRP diverges during F9 cell differentiation.
- Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy.
- Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann n...
- Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions.
- Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein.
- The Heymann nephritis antigenic complex: megalin (gp330) and RAP.
- A Jurkat transcriptional reporter cell line for high-throughput analysis of the nuclear factor-kappaB signaling pathway.
- Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex.
- Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells.
- Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activ...
- Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes.
- gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex.
- All four putative ligand-binding domains in megalin contain pathogenic epitopes capable of inducing passive Heymann nephritis.
- Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes.
- TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.
- Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.
- Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway.
- Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton.
- Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes.
- Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin.
- The receptor-associated protein (RAP) interacts with several resident proteins of the endoplasmic reticulum including a glycoprotein related to actin.
- Megalin is an endocytic receptor for insulin.
- The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin.
Schools
University of Medicine And Dentistry of New Jersey Newark
University Chicago Hosps Clins
Doctors Specialties
- Anatomic Pathology
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Top MD
Education
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University of Chicago -
Rutgers New Jersey Medical School
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