Professor, Medicine, Boston University School of Medicine
Rheumatology
Dr. Robert A. Lafyatis, MD
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Doctor Robert A. Lafyatis, MD works in the field of Rheumatology. He graduated from University of Cincinnati College of Medicine. He over the years received 2 awards: "Fellow" and "Fellow (FACR)". Doctor Robert A. Lafyatis, MD is a published doctor as well. He has 101 publications published. The latest was: Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. Robert A. Lafyatis is registered with Medicare.
Publications
- The relationship between skin symptoms and the Scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in p...
- Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1.
- Local skin gene expression reflects both local and systemic skin Disease in patients with systemic sclerosis.
- A Longitudinal Biomarker for the Extent of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis.
- CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin.
- Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in Systemic sclerosis.
- Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis.
- Immunochip analysis identifies multiple susceptibility Loci for Systemic sclerosis.
- Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis.
- Key roles for interferon- and TGF-beta-regulated genes, and macrophage activation in progressive lung fibrosis associated with Systemic Sclerosis.
- Epstein-Barr Virus Infection Induces Aberrant TLR Activation Pathway and Fibroblast-Myofibroblast Conversion in Scleroderma.
- Global chemokine expression in Systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin.
- Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis.
- HLA-B35 and dsRNA Induce Endothelin-1 via Activation of ATF4 in Human Microvascular Endothelial Cells.
- Increased expression of endoplasmic reticulum stress genes in patients with limited cutaneous Systemic sclerosis and pulmonary arterial hypertension.
- p300 Is Elevated in Systemic Sclerosis and Its Expression Is Positively Regulated by TGF-?: Epigenetic Feed-Forward Amplification of Fibrosis.
- Toll-like receptor 4 signaling augments transforming growth factor-? responses: a novel mechanism for maintaining and amplifying fibrosis in Scleroderma.
- TSLP upregulation in human SSc skin and induction of overlapping profibrotic genes and intracelullar signaling with IL-13 and TGFÃ
- Ciprofloxacin has antifibrotic effects in Scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
- Connective tissue Disease: SSc-fibrosis takes flight with Wingless inhibition.
- A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with Systemic sclerosis and induced by type I interferons and toll-like receptor agoni...
- Myofibroblasts and hyalinized collagen as markers of skin Disease in systemic sclerosis.
- Microfibril-associated MAGP-2 stimulates elastic fiber assembly.
- Targeting fibrosis in Systemic sclerosis.
- Transcription factor T-bet regulates skin Sclerosis through its function in innate immunity and via IL-13.
- B cell infiltration in systemic sclerosis-associated interstitial lung Disease.
- Fibrosis in connective tissue Disease: the role of the myofibroblast and fibroblast-epithelial cell interactions.
- Type I interferons inhibition of inflammatory T helper cell responses in systemic Lupus erythematosus.
- Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
- Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin Deposition and systemic sclerosis.
- Toll-like receptors and innate immune responses in systemic Lupus erythematosus.
- Capillary regeneration in Scleroderma: stem cell therapy reverses phenotype?
- Cartilage oligomeric matrix protein expression in Systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor beta.
- The -2518A>G promoter polymorphism in the CCL2 gene is not associated with Systemic sclerosis susceptibility or phenotype: results from a multicenter study of European...
- TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
- B cell depletion with rituximab in patients with diffuse cutaneous Systemic sclerosis.
- Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in Systemic sclerosis that is possibly implicated in CCL18 se...
- The pronounced Th17 profile in Systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.
- Increased frequency and compromised function of T regulatory cells in Systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.
- Innate immunity and inflammation in Systemic sclerosis.
- Rituximab: a potential therapeutic advance in Scleroderma: what is the evidence?
- A four-gene biomarker predicts skin Disease in patients with diffuse cutaneous systemic sclerosis.
- Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan Syndrome.
- Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous Systemic sclerosis.
- Care of patients with Scleroderma in the intensive care setting.
- Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in Systemic sclerosis.
- Skewed X chromosomal inactivation impacts T regulatory cell function in Systemic sclerosis.
- Generation of transgene-free lung Disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.
- Limited Systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.
- The cytokine language of monocytes and macrophages in Systemic sclerosis.
- dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts.
- The c-Abl tyrosine kinase controls protein kinase Cô-induced Fli-1 phosphorylation in human dermal fibroblasts.
- Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for Scleroderma?
- Interferon and alternative activation of macrophage/monocytes in Systemic sclerosis-associated pulmonary arterial hypertension.
- Role for Toll-like receptor 3 in muscle regeneration after cardiotoxin injury.
- Application of biomarkers to clinical trials in Systemic sclerosis.
- Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets.
- Antibodies in Rheumatoid synovial fluids bind to a restricted series of protein antigens in Rheumatoid synovial tissue.
- Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by Rheumatoid synovium: coexpression with heparin b...
- Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.
- Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system.
- Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif.
- Localization and actions of transforming growth factor-beta s in the embryonic nervous system.
- Multiple forms of TGF-beta: distinct promoters and differential expression.
- Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.
- The cytokine network in rheumatoid Arthritis.
- Endothelial cells and the pathogenesis of rheumatoid Arthritis in humans and streptococcal cell wall Arthritis in Lewis rats.
- Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced Arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion.
- Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
- Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.
- Transforming growth factor-beta in rheumatoid Arthritis.
- IL-1 regulation of transin/stromelysin transcription in Rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prost...
- Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site.
- Cytokines and growth regulation of synoviocytes from patients with rheumatoid Arthritis and rats with streptococcal cell wall Arthritis.
- Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3.
- Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced Arthritis in rats.
- Platelet-derived growth factor and IL-1 interactions in rheumatoid Arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transc...
- Transin/stromelysin expression in Rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes.
- Transforming growth factor-beta production by synovial tissues from Rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fi...
- Transin/stromelysin expression in the synovium of rats with experimental erosive Arthritis. In situ localization and kinetics of expression of the transformation-assoc...
- Mechanisms of bone and cartilage destruction in rheumatoid Arthritis: lessons from the streptococcal cell wall Arthritis model in LEW/N rats.
- Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming g...
- Hyperplastic synoviocytes from rats with streptococcal cell wall-induced Arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable.
- The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.
- Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.
- Xerostomia in Systemic sclerosis: systematic evaluation by salivary scintigraphy and lip biopsy in thirty-four patients.
- Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-whit...
- Regulation of the transforming growth factor-beta 1 and -beta 3 promoters by transcription factor Sp1.
- Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1.
- The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS.
- Alternative splicing of the 5' region of cathepsin B pre-messenger RNA in Rheumatoid synovial tissue.
- Transforming growth factor-beta and platelet derived growth factor regulation of fibrillar fibronectin matrix formation by synovial fibroblasts.
- Rheumatology. Biological agents--is the promise realised?
- Integrin engagement regulates proliferation and collagenase expression of Rheumatoid synovial fibroblasts.
- SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation.
- Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.
- Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins.
- Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3.
- Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation.
- Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure.
Schools
University Of Cincinnati College Of Medicine
North Carolina Baptist Hospital
National Institute Of Musculoskeletal and Skin Disease
Procedures Preformed
- Joint Drainage
- Steroid Injection
Conditions Treated
- Arthritis
- Bursitis
- Calcium Pyrophosphate Dihydrate Deposition Disease (CPPD)
- Degenerative Disc Disease
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Doctors Specialties
- Rheumatology
Accepted Insurances
Awards
- Fellow
- Fellow (FACR)
Education
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National Institutes of Health Clinical Center -
Wake Forest University -
University of Cincinnati College of Medicine
Hospital
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Boston Medical Center
Drug Facts
| NPI NUMBER | 1902896822 | |
| NPPES Provider LastName | LAFYATIS | |
| NPPES Provider FirstName | ROBERT | |
| NPPES Provider ZIPCode | 021182526 | |
| NPPES Provider State | MA | |
| Specialty Description | Rheumatology | |
| Total Claim Count | 973.0 | |
| Distinct Opioid Count | 6.0 | |
| Opioid Claim Count | 131.0 | |
| Percent Opioid Claims | 13.46 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1902896822 |
| Last Name Of The Provider | LAFYATIS |
| First Name Of The Provider | ROBERT |
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