Professor, Medicine, UCSF School of Medicine
Infectious Disease
Dr. Richard M. Locksley, MD
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Dr. Richard M. Locksley practices Infectious Disease. He went to medical school at University of Rochester School of Medicine and Dentistry. He over the years received 2 awards: "Elected Member" and "Investigator". Richard Locksley has written publications. He has 83 publications published with PubMed. The lastest paper is: 'IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.'
Publications
- A Novel Model for IFN-γ-Mediated Autoinflammatory Syndromes.
- IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
- I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.
- Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
- Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis.
- Allergic Inflammation-Innately Homeostatic.
- Interleukin-5 producing group 2 innate lymphoid cells (ILC2) control eosinophilia induced by interleukin-2 therapy.
- Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
- Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
- Eosinophils are Recruited in Response to Chitin Exposure and Enhance Th2-Mediated Immune Pathology in Aspergillus fumigatus infection.
- Asthma and the flu: a tricky two-step.
- Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells.
- Type 2 innate lymphoid cells control eosinophil homeostasis.
- Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.
- Eosinophils secrete IL-4 to facilitate liver regeneration.
- Traumatic brain injury induces macrophage subsets in the brain.
- Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
- Raggin' on T-bet.
- Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
- Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease.
- Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin e.
- Marking and Quantifying IL-17A-Producing Cells In Vivo.
- Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
- Infectious (Non)tolerance--Frustrated Commensalism Gone Awry?
- A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.
- Deletion of syk in neutrophils prevents immune complex arthritis.
- The airway epithelium as a regulator of th2 responses in asthma.
- Fungal Chitin from Asthma-Associated Home Environments Induces Eosinophilic Lung Infiltration.
- Genetic analysis of basophil function in vivo.
- Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
- Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
- IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
- Lymphocyte development requires S-nitrosoglutathione reductase.
- Murine B cells regulate serum IgE levels in a CD23-dependent manner.
- Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
- Asthma and allergic inflammation.
- Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands.
- IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway.
- Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
- Nine lives: plasticity among T helper cell subsets.
- Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
- In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.
- Cytokine-secreting follicular T cells shape the antibody repertoire.
- Basophils: a nonredundant contributor to host immunity.
- Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.
- Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
- Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
- Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.
- Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
- Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.
- The Roaring Twenties.
- Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
- Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.
- Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages.
- IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
- Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
- A failure to launch: fuelling cytokine secretion in iNKT cells.
- Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
- Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
- Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.
- Activation of the integrated stress response during T helper cell differentiation.
- Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence.
- TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
- Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
- A two-step process for cytokine production revealed by IL-4 dual-reporter mice.
- Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
- Interleukin-4 can be a key positive regulator of inflammatory arthritis.
- CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
- The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice.
- Innate immune responses in peptidoglycan recognition protein L-deficient mice.
- Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production.
- Th2 cells: orchestrating barrier immunity.
- Basal chromatin modification at the IL-4 gene in helper T cells.
- Leishmania major LACK antigen is required for efficient vertebrate parasitization.
- Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
- Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
- Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity.
- Stat signals release activated naive Th cells from an anergic checkpoint.
- CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
- Blood lines.
- Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.
- Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the o...
Schools
University Of Rochester
Moffitt Hospital University Of Ca
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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UCSF -
University of Rochester School of Medicine and Dentistry
Hospital
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UCSF Medical Center
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