Associate Professor of Pediatrics, University Pittsburgh
Pediatric Hematology & Oncology
Dr. Regina I. Jakacki, MD
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Regina Jakacki is an expert in the field of Pediatric Hematology & Oncology. She graduated from Perelman School of Medicine at the University of Pennsylvania. She received 3 awards: "America's Top Doctors", "America's Top Doctors for Cancer" and "Pittsburgh Magazine". Regina Jakacki has written publications. She has 69 publications published with PubMed. The lastest publication is: 'Imaging the central nervous system effects of radiation and chemotherapy of pediatric tumors.'
Publications
- A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors.
- Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Childr...
- Neurocutaneous melanosis is associated with tethered spinal cord.
- Bevacizumab for symptomatic radiation-induced tumor enlargement in pediatric low grade Gliomas.
- Pseudoprogression of low-grade Gliomas after radiotherapy.
- Ketamine PCA for Treatment of End-of-Life Neuropathic Pain in Pediatrics.
- Multimodality therapy for CNS mixed malignant germ cell tumors (MMGCT): results of a phase II multi-institutional study.
- The development of moyamoya syndrome after proton beam therapy.
- Marked Recovery of Vision in Children With Optic Pathway Gliomas Treated With Bevacizumab.
- Ependymomas: development of immunotherapeutic strategies.
- Bevacizumab (BVZ)-associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT-11): A Pediatric Brain Tumor Cons...
- Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade Gliomas.
- Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy.
- Bevacizumab-associated osteonecrosis of the wrist and knee in three pediatric patients with recurrent CNS tumors.
- Motexafin-gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a children's oncology group phase 2 study.
- Optic pathway glioma as part of a constitutional mismatch-repair deficiency syndrome in a patient meeting the criteria for neurofibromatosis type 1.
- A phase 1 study of vinblastine in combination with carboplatin for children with low-grade Gliomas: a Children's Oncology Group phase 1 consortium study.
- Childhood Brain tumors: epidemiology, current management and future directions.
- Stereotactic radiosurgery for pilocytic Astrocytomas part 2: outcomes in pediatric patients.
- Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.
- A phase I trial of temozolomide and lomustine in newly diagnosed high-grade Gliomas of childhood.
- Extraventricular neurocytoma in neurofibromatosis Type 1: case report.
- Phase I trial of imatinib in children with newly diagnosed Brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report.
- Treatment strategies for high-risk Medulloblastoma and supratentorial primitive neuroectodermal tumors. Review of the literature.
- A pilot study of preirradiation chemotherapy and 1800 cGy craniospinal irradiation in young children with Medulloblastoma.
- Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central Nervous system germinoma.
- Immunization of leukemic children with Haemophilus conjugate vaccine.
- Multiple hemangioendotheliomas of the liver.
- Haemophilus influenzae diphtheria protein conjugate immunization after therapy in splenectomized patients with Hodgkin Disease.
- Chondrosarcoma.
- Carboplatin and vincristine for recurrent and newly diagnosed low-grade Gliomas of childhood.
- Treatment of diencephalic syndrome with chemotherapy: growth, tumor response, and long term control.
- Flow cytometric DNA analysis of pediatric intracranial ependymomas.
- Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade Gliomas.
- A phase I/II study of carboplatin combined with hyperfractionated radiotherapy for Brainstem gliomas.
- Recurrent Medulloblastoma following pediatric double-lung transplant.
- Quantitative analysis of three-dimensional conformal radiotherapy techniques for posterior fossa treatment in children.
- NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight.
- Phase II trial of intravenous lobradimil and carboplatin in childhood Brain tumors: a report from the Children''s Oncology Group.
- Pharmacokinetics of phenylacetate administered as a 30-min infusion in children with refractory Cancer.
- A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk Medulloblastoma/primitive neuroectodermal tum...
- Objective response of multiply recurrent low-grade Gliomas to bevacizumab and irinotecan.
- Phase 1 and pharmacokinetic study of concurrent carboplatin and irinotecan in subjects aged 1 to 21 years with refractory solid tumors.
- Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018.
- A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed Brainstem gliomas.
- Phase 1 study of concurrent RMP-7 and carboplatin with radiotherapy for children with newly diagnosed Brainstem gliomas.
- Imaging the central Nervous system effects of radiation and chemotherapy of pediatric tumors.
- Dose-intensification of procarbazine, CCNU (lomustine), vincristine (PCV) with peripheral blood stem cell support in young patients with Gliomas.
- Phase II evaluation of topotecan for pediatric central Nervous system tumors.
- Cardiac dysfunction following spinal irradiation during childhood.
- Treatment of standard risk Medulloblastoma with craniospinal irradiation, carboplatin, and vincristine.
- Feasibility of sequential high-dose chemotherapy and peripheral blood stem cell support for pediatric central Nervous system malignancies.
- Testing the hypothalamic-pituitary-Adrenal axis in survivors of childhood brain and skull-based tumors.
- Comparison of cardiac function tests after anthracycline therapy in childhood. Implications for screening.
- Increased risk of cardiac dysfunction after anthracyclines in girls.
- Restrictive lung disease following treatment for malignant Brain tumors: a potential late effect of craniospinal irradiation.
- Survival and prognostic factors following radiation and/or chemotherapy for primitive neuroectodermal tumors of the pineal region in infants and children: a report of ...
- Pulsatile secretion of luteinizing hormone in children.
- Electrocardiographic changes and arrhythmias after Cancer therapy in children and young adults.
- Phase II evaluation of interferon-alpha-2a for progressive or recurrent craniopharyngiomas.
- Dose-intensive, time-compressed procarbazine, CCNU, vincristine (PCV) with peripheral blood stem cell support and concurrent radiation in patients with newly diagnosed...
- Pineal and nonpineal supratentorial primitive neuroectodermal tumors.
- IDH1 mutations are common in malignant Gliomas arising in adolescents: a report from the Children''s Oncology Group.
- Akt activation is a common event in pediatric malignant Gliomas and a potential adverse prognostic marker: a report from the Children''s Oncology Group.
- Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant Gliomas: a report from the Children''s Oncology Group.
- A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples.
- Phase I trial of pegylated interferon-alpha-2b in young patients with plexiform neurofibromas.
- Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the C...
Schools
Univ Of Pa Sch Of Med
Children39s Hospital Of Philadelphia
Conditions Treated
- Acute Leukemia
- Adrenal Gland Cancer
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Pittsburgh Magazine
Education
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Children's Hospital of Philadelphia -
Perelman School of Medicine at the University of Pennsylvania
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