Assistant Professor of Neurology, Massachusetts General Hospital
Neurology
Dr. Raymond J. Kelleher III, MD
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Raymond Kelleher is an expert in the field of Neurology. He attended Stanford University School of Medicine. Stanford University School of Medicine is a top medical university. Stanford University School of Medicine is ranked 2 in research and 25 in primary care medicine Dr. Raymond J. Kelleher III is a published doctor. He has 28 papers published. The most current publication "Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade." Raymond Kelleher accepts all Medicare patients.
Publications
- Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade.
- Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease.
- Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on γ-Secretase Activity and Aβ Production.
- Exposure to Factor VIII in the presence of Phosphatidylserine induces hypo-responsiveness towards Factor VIII challenge in Hemophilia A mice.
- Familial Frontotemporal Dementia-Associated Presenilin-1 c.548G>T Mutation Causes Decreased mRNA Expression and Reduced Presenilin Function in Knock-In Mice.
- Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain.
- Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis.
- Genetics. Gamma-secretase and human Disease.
- Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors.
- A presenilin-1 mutation identified in familial Alzheimer Disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
- Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.
- IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments.
- Indirect regulation of presenilins in CREB-mediated transcription.
- Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" ...
- The autistic neuron: troubled translation?
- Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null...
- Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.
- The presenilin hypothesis of Alzheimer's Disease: evidence for a loss-of-function pathogenic mechanism.
- B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells.
- Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-ga...
- Translational regulatory mechanisms in persistent forms of synaptic plasticity.
- Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells.
- Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
- Translational control by MAPK signaling in long-term synaptic plasticity and memory.
- Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.
- Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells.
Schools
Stanford University School Of Medicine
Massachusetts General Hospital
Procedures Preformed
- EEG (Electroencephalogram)
- EMG (Electromyography)
Conditions Treated
- Alzheimer's Disease
- Convulsions
- Parkinson's Disease
Doctors Specialties
- Neurology
Accepted Insurances
Education
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Massachusetts General Hospital -
Stanford University School of Medicine
Hospital
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Massachusetts General Hospital
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