Professor, Pharmacological/Physiological Sciences, St Louis University School of Medicine
Pulmonology
Dr. Randy S. Sprague, MD
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Randy Sprague is an expert in the field of Pulmonology. He went to medical school at Saint Louis University School of Medicine. Saint Louis University School of Medicine is ranked 67 in research and 57 in primary care medicine Randy Sprague is a published physician as well. He has 88 publications published. The latest was: Deformation-induced ATP release from red blood cells requires CFTR activity.
Publications
- Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle.
- Mechanisms of C-peptide-mediated rescue of low O2-induced ATP release from erythrocytes of humans with Type 2 diabetes.
- Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with pulmonary arterial hypertension.
- Prostacyclin receptor expression on platelets of humans with type 2 diabetes is inversely correlated with hemoglobin A1c levels.
- Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin.
- Reply by the authors to the comments of Mortimer Lorber, MD.
- Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3',5' monophosphate accumulation and adenosine 3'5' triphosphate relea...
- Simvastatin and GGTI-2133, a geranylgeranyl transferase inhibitor, increase erythrocyte deformability but reduce low O2 tension-induced ATP release.
- Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP.
- Erythrocyte-derived ATP and Perfusion Distribution: Role of Intracellular and Intercellular Communication.
- Prostacyclin Receptor-Mediated ATP Release from Erythrocytes Requires the Voltage-Dependent Anion Channel (VDAC).
- A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: Implication for vascular control.
- The Rho kinase inhibitor, Y27632 increases erythrocyte deformability and low oxygen tension-induced ATP release.
- Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
- Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes.
- Divergent effects of low-O(2) tension and iloprost on ATP release from erythrocytes of humans with type 2 diabetes: implications for O(2) supply to skeletal muscle.
- Vascular disease in pre-diabetes: new insights derived from systems biology.
- Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats.
- Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes.
- Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans.
- Erythrocytes: oxygen sensors and modulators of vascular tone.
- Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP.
- Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes.
- Red not dead: signaling in and from erythrocytes.
- Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries.
- Reduced expression of G(i) in erythrocytes of humans with type 2 diabetes is associated with impairment of both cAMP generation and ATP release.
- 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase.
- Erythrocytes of humans with cystic fibrosis fail to stimulate nitric oxide synthesis in isolated rabbit lungs.
- NO inhibits signal transduction pathway for ATP release from erythrocytes via its action on heterotrimeric G protein Gi.
- Nitric oxide inhibits ATP release from erythrocytes.
- Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes.
- Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance.
- COX and the control of the pulmonary circulation.
- Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit.
- The stoichiometric fate of azaserine metabolized in vitro by tissues from azaserine-treated dogs and mice.
- Pseudohyponatremia in multiple myeloma.
- Expression of the heterotrimeric G protein Gi and ATP release are impaired in erythrocytes of humans with diabetes mellitus.
- Chemiluminescence detection of ATP release from red blood cells upon passage through microbore tubing.
- Determination of ATP release from erythrocytes using microbore tubing as a model of resistance vessels in vivo.
- Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi.
- Relaxation of porcine coronary artery to bradykinin. Role of arachidonic acid.
- Effect of indomethacin on increases in leukotriene B4 and pulmonary edema in response to phorbol ester administration in dogs.
- Inhibition of nitric oxide synthesis results in a selective increase in arterial resistance in rabbit lungs.
- Endothelium-dependent relaxation to arachidonic acid in porcine coronary artery: is there a fourth pathway?
- Relationship of arachidonic acid release to porcine coronary artery relaxation.
- Alterations in the fraction of oxygen in inspired gas affect rates of renal prostaglandin E2 synthesis in anesthetized dogs.
- Effect of ventilatory rate on renal venous PGE2 and PGF2 alpha efflux in anesthetized dogs.
- Unilateral acute lung injury induced by ethchlorvynol in anesthetized dogs.
- Differential response of the pulmonary circulation to prostaglandins E2 and F2 alpha in the presence of unilateral alveolar hypoxia.
- Prostaglandin I2 supports blood flow to hypoxic alveoli in anesthetized dogs.
- Effects of ibuprofen on the hypoxemia of established ethchlorvynol-induced unilateral acute lung injury in anesthetized dogs.
- Increased leukotriene C4 in ethchlorvynol-induced acute lung injury in dogs.
- Relationship of leukotriene C4 and D4 to hypoxic pulmonary vasoconstriction in dogs.
- Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs.
- Proposed role for leukotrienes in the pathophysiology of multiple systems organ failure.
- Leukotrienes and the microvascular permeability of acute lung injury.
- Thromboxane does not mediate pulmonary hypertension in phorbol ester-induced acute lung injury in dogs.
- Production of leukotrienes in phorbol ester-induced acute lung injury.
- Identification of the anterior psoas sheath as a landmark for lumbar sympathetic block.
- Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
- Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits.
- Enhanced microvascular permeability of PMA-induced acute lung injury is not mediated by cyclooxygenase products.
- OKY-046 prevents increases in LTB4 and pulmonary edema in phorbol ester-induced lung injury in dogs.
- Receptor-mediated activation of the heterotrimeric G-protein Gs results in ATP release from erythrocytes.
- Impaired release of ATP from red blood cells of humans with primary pulmonary hypertension.
- Red blood cell regulation of microvascular tone through adenosine triphosphate.
- Deformation-induced ATP release from red blood cells requires CFTR activity.
- 5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog.
- Biosynthesis of sulfidopeptide leukotrienes via the transfer of leukotriene A4 from polymorphonuclear cells to bovine retinal pericytes.
- Nitric oxide opposes phorbol ester-induced increases in pulmonary microvascular permeability in dogs.
- Vascular endothelial growth factor mRNA in pericytes is upregulated by phorbol myristate acetate.
- ATP: the red blood cell link to NO and local control of the pulmonary circulation.
- Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs.
- Inhibition of nitric oxide synthesis improves arterial oxygenation in ethchlorvynol-induced acute lung injury in dogs.
- Effect of L-NAME on pressure-flow relationships in isolated rabbit lungs: role of red blood cells.
- Hypotheses regarding the role of pericytes in regulating movement of fluid, nutrients, and hormones across the microcirculatory endothelial barrier.
- Timing of fledging is influenced by glucocorticoid physiology in Laysan Albatross chicks.
- Erythrocytes as controllers of perfusion distribution in the microvasculature of skeletal muscle.
- Plasma-binding globulins and acute stress response.
- The role of G protein beta subunits in the release of ATP from human erythrocytes.
- Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP release.
- Rabbit erythrocytes release ATP and dilate skeletal muscle arterioles in the presence of reduced oxygen tension.
- Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular control.
- Diamide decreases deformability of rabbit erythrocytes and attenuates low oxygen tension-induced ATP release.
- Regulation of cAMP by phosphodiesterases in erythrocytes.
- Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase.
- Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5.
Schools
Saint Louis University School Of Medicine
St Louis University Hospital
Doctors Specialties
- Pulmonology
Accepted Insurances
Education
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St Louis University School of Medicine -
Saint Louis University School of Medicine
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