Professor and Vice Chair, Medicine, University of Pittsburgh School of Medicine
Pulmonology
Dr. Rama K. Mallampalli, MD
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Rama Mallampalli is an expert in the field of Pulmonology. He attended University of Wisconsin School of Medicine and Public Health. Rama Mallampalli has written publications. He has 90 publications published with PubMed. The lastest publication is: 'Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia.'
Publications
- Small molecule therapeutics targeting F-box proteins in Cancer.
- Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.
- The Ubiquitin E3 Ligase SCF-FBXO24 Recognizes Deacetylated Nucleoside Diphosphate Kinase A To Enhance Its Degradation.
- The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections.
- The acute respiratory distress syndrome: from mechanism to translation.
- Cardiolipin Signaling Mechanisms: Collapse of Asymmetry and Oxidation.
- Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.
- Decoding the growth advantage of hypoxia-sensitive Lung cancer.
- Glycogen Synthase Kinase-3β Stabilizes the Interleukin (IL)-22 Receptor from Proteasomal Degradation in Murine Lung Epithelia.
- Lung Macrophages "Digest" Carbon Nanotubes Using a Superoxide/Peroxynitrite Oxidative Pathway.
- Long-chain Acyl-CoA Dehydrogenase Deficiency as a Cause of Pulmonary Surfactant Dysfunction.
- E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia.
- Regulation of histone modifying enzymes by the ubiquitin-proteasome system.
- Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation.
- A new mechanism of RhoA ubiquitination and degradation: Roles of SCF(FBXL19) E3 ligase and Erk2.
- The Emerging Role of the Ubiquitin Proteasome in Pulmonary Biology and Disease.
- Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.
- A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.
- New insights on the function of SCF ubiquitin E3 ligases in the Lung.
- F-box protein substrate recognition: A new insight.
- SCF E3 ligase F-box protein complex SCFFBXL19 regulates cell migration by mediating Rac1 ubiquitination and degradation.
- Surfactant phospholipid metabolism.
- SCFFbxw15 Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation.
- SPLUNC1/BPIFA1 Contributes to Pulmonary Host Defense against Klebsiella Pneumoniae Respiratory Infection.
- Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis.
- STAT1-regulated Lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia.
- Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A causing mitotic arrest.
- FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
- 14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulates the six-to-five heme pocket coordination and the rate of nitrite reduction to nitric oxide.
- Surfactant and its role in the pathobiology of Pulmonary infection.
- PLUNC: a multifunctional surfactant of the airways.
- Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis.
- Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis.
- Reply to "The flip side of cardiolipin import".
- LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant en...
- Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of Lung injury in experimental pneumonia.
- Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1.
- 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in Lung epithelia.
- Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination.
- PLUNC is a novel airway surfactant protein with anti-biofilm activity.
- Masking of a nuclear signal motif by monoubiquitination leads to mislocalization and degradation of the regulatory enzyme cytidylyltransferase.
- 15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase.
- Human adenovirus modulates surfactant phospholipid trafficking.
- Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase.
- Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR.
- Chronic Pseudomonas aeruginosa infection reduces surfactant levels by inhibiting its biosynthesis.
- Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis.
- Transcriptional regulation of Lung cytidylyltransferase in developing transgenic mice.
- Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced Lung injury.
- c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase.
- Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.
- LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in Lung epithelia.
- Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein.
- Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2.
- Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine.
- Upregulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux.
- Oxysterols trigger ABCA1-mediated basolateral surfactant efflux.
- Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.
- Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.
- The CCT promoter directs high-level transgene expression in distal Lung epithelial cell lines.
- Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated cleavage of CTP:phosphocholine cytidylyltransferase.
- Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity.
- Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis.
- Pulmonary-specific expression of tumor necrosis factor-alpha alters surfactant lipid metabolism.
- Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promo...
- Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages.
- Lipoprotein deprivation stimulates transcription of the CTP:phosphocholine cytidylyltransferase gene.
- Tumor necrosis factor-alpha inhibits expression of CTP:phosphocholine cytidylyltransferase.
- Effects of intratracheal instillation of TNF-alpha on surfactant metabolism.
- Identification of sex-specific differences in surfactant synthesis in rat Lung.
- TNF-alpha increases ceramide without inducing apoptosis in alveolar type II epithelial cells.
- A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macroph...
- Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous Lungs and regulation by hypoxia.
- Sphingomyelin metabolism is developmentally regulated in rat Lung.
- Very low density lipoproteins stimulate surfactant lipid synthesis in vitro.
- Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat Lung.
- gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibi...
- Oxygen modulates surfactant protein mRNA expression and phospholipid production in human fetal Lung in vitro.
- Betamethasone activation of CTP:cholinephosphate cytidylyltransferase is mediated by fatty acids.
- Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids.
- Epidermal growth factor is a positive in vivo regulator of CTP:cholinephosphate cytidylyltransferase.
- Betamethasone activation of CTP:cholinephosphate cytidylyltransferase in vivo is lipid dependent.
- Expression of immunoreactive cytidine 5'-triphosphate: cholinephosphate cytidylyltransferase in developing rat Lung.
- Lung CTP:choline-phosphate cytidylyltransferase: activation of cytosolic species by unsaturated fatty acid.
- Isolation and immortalization of rat pre-type II cell lines.
- Nonreactive pupils due to monoamine oxidase inhibitor overdose.
- F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
- Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis.
- Crystal Structure and Interaction Studies of the Human FBxo3 ApaG Domain.
Schools
University of Wisconsin Madison
Hennepin Co Mc
University Iowa Hosps and Clins
Conditions Treated
- COPD (Chronic Obstructive Pulmonary Disease)
- Lung Cancer
Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
- Cigna
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
- United Healthcare
Education
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University of Iowa Hospitals and Clinics -
Hennepin County Medical Center -
University of Wisconsin School of Medicine and Public Health
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