D.K. Ludwig Professor of Rad and Cellular Oncology, University of Chicago Medicine
Radiation Oncology
Dr. Ralph R. Weichselbaum, MD
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Ralph Weichselbaum works in the field of Radiation Oncology. He attended University of Illinois College of Medicine. He has 2 awards "Elected Member" and "Super Doctor". Doctor Ralph R. Weichselbaum, MD is also published. He has 99 publications published. The lastest publication: "Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.'
Publications
- Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.
- RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
- MUC1-C activates the TAK1 inflammatory pathway in colon cancer.
- Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes.
- Increasing radiation therapy dose is associated with improved survival in patients undergoing stereotactic body radiation therapy for stage I non-small-cell lung cancer.
- Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.
- S-phase-dependent p50/NF-úB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability.
- Defining the Benefit of Adjuvant Therapy Following Resection for Intrahepatic Cholangiocarcinoma.
- Loss of Nfkb1 leads to early onset aging.
- Disparities in Treatment of Patients with Inoperable Stage I Non-Small Cell Lung Cancer: A Population-Based Analysis.
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
- Combination of linear accelerator-based intensity-modulated total marrow irradiation and myeloablative fludarabine/busulfan: a phase I study.
- Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer.
- Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor.
- Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs.
- The Effect of Radiotherapy Dose on Survival in Stage III Non-Small-Cell Lung Cancer Patients Undergoing Definitive Chemoradiotherapy.
- The oligometastatic state-separating truth from wishful thinking.
- DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy.
- An analysis of radiation necrosis of the central nervous system treated with bevacizumab.
- A Phase I trial of Oncolytic HSV-1, G207, Given in Combination with Radiation for Recurrent GBM demonstrates Safety and Radiographic Responses.
- RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
- Stereotactic body radiotherapy for the treatment of oligometastatic renal cell carcinoma.
- Small molecule derived from a natural product that mitigates radiation injury.
- Effect of Postradiotherapy Neck Dissection on Nonregional Disease Sites.
- Race and competing mortality in advanced head and neck cancer.
- Racial parities in outcomes after radiotherapy for head and neck cancer.
- EPR Oxygen Images Predict Tumor Control by a 50% Tumor Control Radiation Dose.
- Comparison of carboplatin-paclitaxel to docetaxel-cisplatin-5-flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and ne...
- Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma.
- A survivin-associated adaptive response in radiation therapy.
- Radiation-Induced Equilibrium Is a Balance between Tumor Cell Proliferation and T Cell-Mediated Killing.
- Improved Survival Associated with Neoadjuvant Chemoradiation in Patients with Clinical Stage IIIA(N2) Non-Small-Cell Lung Cancer.
- Extracranial oligometastases: a subset of metastases curable with stereotactic radiotherapy.
- Role of MIF in Age-Related Susceptibility to Radiation Lung Injury Via Nrf2 and Antioxidant Regulation.
- A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing ...
- Sphingosine-1-Phosphate, FTY720 and Sphingosine-1-Phosphate Receptors in the Pathobiology of Acute Lung Injury.
- A Manganese Superoxide Dismutase (SOD2)-Mediated Adaptive Response.
- Modulating vascular intimal hyperplasia using HSV-1 mutant requires activated MEK.
- New paradigms and future challenges in radiation oncology: an update of biological targets and technology.
- DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site.
- Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.
- Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.
- Molecular Pathways: Interferon/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth.
- Hypofractionated Image-Guided Radiation Therapy for Patients with Limited Volume Metastatic Non-small Cell Lung Cancer.
- Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner.
- p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.
- Mg ATP and antioxidants augment the radioprotective effect of surfactant copolymers.
- Stereotactic body radiotherapy for multisite extracranial oligometastases: Final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease.
- Improved survival time trends for glioblastoma using the SEER 17 population-based registries.
- Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs.
- Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
- The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity.
- Oligometastases revisited.
- Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression.
- Outcomes in black patients with early breast cancer treated with breast conservation therapy.
- MicroRNA Expression Characterizes Oligometastasis(es).
- A downside to apoptosis in cancer therapy?
- Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes.
- Predictors of competing mortality in early breast cancer.
- Where It's at Really Matters: In Situ In Vivo Vascular Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO(2) Images in Tumors of Li...
- Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.
- Concomitant proliferation and caspase-3 mediated apoptosis in response to low shear stress and balloon injury.
- Statin use and risk of prostate cancer recurrence in men treated with radiation therapy.
- Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.
- Vascular endothelial growth factor pathway.
- Dose-escalated radiotherapy for high-risk prostate cancer: outcomes in modern era with short-term androgen deprivation therapy.
- Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis.
- Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy.
- Predictors of competing mortality in advanced head and neck cancer.
- Extraction and assembly of tissue-derived gels for cell culture and tissue engineering.
- Characterization of response to radiation mediated gene therapy by means of multimodality imaging.
- Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy.
- Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.
- Dose-escalated radiation therapy for intermediate-risk prostate cancer: patient selection for androgen deprivation therapy using percentage of positive cores.
- MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.
- MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer.
- STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.
- MUCing around with tumor suppression.
- An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer.
- Magnetic resonance imaging identifies multifocal and multicentric disease in breast cancer patients who are eligible for partial breast irradiation.
- A chemical compound that stimulates the human homologous recombination protein RAD51.
- A rationale for the targeted treatment of oligometastases with radiotherapy.
- An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease.
- Salvage radiotherapy after postprostatectomy biochemical failure: does pretreatment radioimmunoscintigraphy help select patients with locally confined disease?
- Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer.
- More on cetuximab in head and neck cancer.
- Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy.
- Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.
- Characterization of the theorectical radiation dose enhancement from nanoparticles.
- Enhancing radiotherapy with genetically engineered viruses.
- Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
- Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow.
- Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
- Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
- Establishment of a syngeneic model of hepatic colorectal oligometastases.
- ReVOLT: radiation-enhanced viral oncolytic therapy.
- Role of external beam radiotherapy with low-dose-rate brachytherapy in treatment of prostate cancer.
- Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
Schools
University of Illinois At Chicago College of Medicine
Highland Alameda Co Hospital
Harvard Med School
Jt Center Rad Therapy
Harvard School Ph
Doctors Specialties
- Radiation Oncology
- Radiology
Accepted Insurances
Awards
- Elected Member
- Super Doctor
Education
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Brigham and Women's Hospital -
Alameda County Medical Center -
University of Illinois College of Medicine
Hospital
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University of Chicago Medical Center -
University of Illinois Hospital & Health Sciences System
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