Lillly Professor at Indiana University School of Medicine
Endocrinology
Dr. Raghavendra G. Mirmira, MD
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Raghavendra Mirmira is an expert in the field of Endocrinology. He attended University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10/19 in Research/PrimaryCare. He has 3 awards "America's Top Doctors", "Indianapolis Monthly" and "Elected Member". Raghavendra Mirmira has written publications. He has 79 publications published with PubMed. The lastest paper is: 'Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase.' He is registered with Medicare and accepts Medicare payments.
Publications
- Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 Diabetes.
- Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.
- Transcriptional Activity of the Islet β Cell Factor Pdx1 is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9.
- Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 Diabetes.
- 12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.
- Editorial: in praise of scientific review officers.
- Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
- Editorial: the vulnerable physician-scientist.
- Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β Cells via Activation of the Mammalian Target of Rapamycin Pathway.
- From immunobiology to β-cell biology: The changing perspective on type 1 Diabetes.
- SYNTAXIN 4 UPREGULATION INCREASES EFFICIENCY OF INSULIN RELEASE IN PANCREATIC ISLETS FROM HUMANS WITH AND WITHOUT TYPE 2 Diabetes MELLITUS.
- Mouse and human islets survive and function after coating by biosilicification.
- Deoxyhypusine Synthase Promotes Differentiation and Proliferation of Th1 Cells in Autoimmune Diabetes.
- Divergent Compensatory Responses to High Fat Diet Between C57BL6/J and C57BLKs/J Inbred Mouse Strains.
- Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in Diabetes mellitus.
- Detection of Islet β-Cell Death in Vivo by Multiplex PCR Analysis of Differentially Methylated DNA.
- Protective effects of polyamine depletion in mouse models of type 1 Diabetes: implications for therapy.
- Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 Diabetes.
- Achieving "PeaK-A" Insulin Secretion.
- Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15(null) Mice, Leading to Protection against Type 1 Diabetes Development.
- Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet ?-Cells.
- Mitogen-Inducible Gene 6 Triggers Apoptosis and Exacerbates ER Stress-Induced β-Cell Death.
- Mouse Islet of Langerhans Isolation using a Combination of Purified Collagenase and Neutral Protease.
- Targeting Regulatory T Cells In The Treatment Of Type 1 Diabetes Mellitus.
- Saturated free fatty acids: islet β cell "stressERs".
- Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study.
- Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine.
- Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice.
- Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
- Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 Diabetes.
- Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
- The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced Diabetes and pancreatic beta-cell dysfunction.
- An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.
- Hypusine: a new target for therapeutic intervention in diabetic inflammation.
- The unique hypusine modification of eIF5A promotes islet beta cell inflammation and Dysfunction in mice.
- Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
- Inducible pluripotent stem cells: not quite ready for prime time?
- Stem cells and the future of organ transplantation.
- Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.
- Expression and function of Set7/9 in pancreatic islets.
- Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance ...
- Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.
- Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation.
- Development of insulin-producing cells from primitive biologic precursors.
- Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.
- Research resource: nuclear hormone receptor expression in the endocrine pancreas.
- Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.
- Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
- Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.
- Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
- A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.
- Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.
- Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.
- Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.
- The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter.
- The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
- Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formati...
- The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation:...
- Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.
- Transcription factors direct the development and function of pancreatic beta cells.
- Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter bi...
- Visible light-initiated interfacial thiol-norbornene photopolymerization for forming islet surface conformal coating.
- Characterization of a novel polyclonal anti-hypusine antibody.
- Regulation of the pancreatic pro-endocrine gene neurogenin3.
- Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.
- Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.
- Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
- The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.
- Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase.
- Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/Type I insulin-like growth factor receptors.
- Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation.
- An insulin-like growth factor I/insulin hybrid exhibiting high potency for interaction with the Type I insulin-like growth factor and insulin receptors of placental pl...
- Physicochemical characterization of bovine retinal arrestin.
- Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.
- Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions.
- Differential expression of cell cycle proteins during ageing of pancreatic islet cells.
- AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
- Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.
Schools
University Of ChicagoThe Pritzker School Of Medicine
University Calif
Conditions Treated
- Adrenogenital Disorders
- Diabetes Type 1
- Diabetes Type 2
- Hyperlipidemia
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- America's Top Doctors
- Indianapolis Monthly
- Elected Member
Education
-
UCSF -
University of Chicago Pritzker School of Medicine
Drug Facts
| NPI NUMBER | 1417099771 | |
| NPPES Provider LastName | MIRMIRA | |
| NPPES Provider FirstName | RAGHAVENDRA | |
| NPPES Provider ZIPCode | 462025109 | |
| NPPES Provider State | IN | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 41.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1417099771 |
| Last Name Of The Provider | MIRMIRA |
| First Name Of The Provider | RAGHAVENDRA |
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