Professor, Internal Medicine, Washington University School of Medicine

Hematology

Philip Majerus works in the field of Hematology. He attended Washington University School of Medicine in St. Louis. He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Philip Majerus is a published doctor and has 100 publications published. The lastest was: 'The measurement of thrombin in clotting blood by radioimmunoassay.'

Publications

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• The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death.
• Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans.
• Wandering through the laboratory.
• Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
• INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia.
• Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.
• Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase.
• Phosphoinositide phosphatases and disease.
• MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.
• A discrete signaling function for an inositol pyrophosphate.
• Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
• Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate.
• The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
• Increased levels of inositol hexakisphosphate (InsP6) protect HEK293 cells from tumor necrosis factor (alpha)- and Fas-induced apoptosis.
• Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression.
• Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
• The pathway for the production of inositol hexakisphosphate in human cells.
• Blasts from the past.
• The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin.
• The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.
• Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.
• Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
• Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.
• Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.
• The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.
• The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase.
• Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death.
• Variations in fibrinolytic activity of human whole saliva.
• Ochratoxin A (OTA) in coffee: nation-wide evaluation of data collected by German Food Control 1995-1999.
• The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.
• Occurrence of ochratoxin A (OTA) in wines: influence of the type of wine and its geographical origin.
• [Thin-layer chromatography and high-pressure liquid chromatography in mycotoxin analysis].
• Susceptibility of anaerobic microorganisms to hypothiocyanite produced by lactoperoxidase.
• A rapid, sensitive and economic method for the detection, quantification and confirmation of aflatoxins.
• Sterilization potential of the CO2 laser.
• [Antiseptic properties of saliva and metabolism of activated oxygen in neutrophils: comparison of the 2 enzymatic bactericidal systems and of their behavior in an acid...
• Candidicidal activity of the human recombinant myeloperoxidase system.
• Human genetics. Bad blood by mutation.
• Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography.
• Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.
• Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells.
• Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.
• Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
• Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitro.
• Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.
• The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.
• Properties of type II inositol polyphosphate 5-phosphatase.
• The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
• The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets.
• Purification and characterization of human coagulation factor V.
• Bradykinin-stimulated release of arachidonate from phosphatidyl inositol in mouse fibrosarcoma cells.
• Diglyceride lipase: a pathway for arachidonate release from human platelets.
• Factor Va-dependent binding of factor Xa to human platelets.
• Purification and properties of human coagulation factor VII.
• Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.
• Characterization and assay of diacylglycerol lipase from human platelets.
• Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982.
• Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands.
• The interaction of human coagulation factor Va with platelets.
• Discovery of an arachidonoyl coenzyme A synthetase in human platelets.
• Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets.
• Development and characterization of a tissue culture cell line with essential fatty acid deficiency.
• Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.
• The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets.
• Thrombin-induced hydrolysis of phosphatidylinositol in human platelets.
• Activation of coagulation factor V by a platelet protease.
• Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase.
• Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase.
• Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets.
• Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.
• Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III.
• The isolation and characterization of inositol polyphosphate 4-phosphatase.
• Structure and function of thrombomodulin: a natural anticoagulant.
• The phosphatidylinositol pathway of platelets and vascular cells.
• Cyclic hydrolase-transfected 3T3 cells have low levels of inositol 1,2-cyclic phosphate and reach confluence at low density.
• Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts.
• Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosph...
• Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.
• The George M. Kober Lecture: molecular mechanisms of intracellular signal transduction.
• Diverse proteins homologous to inositol monophosphatase.
• Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.
• Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
• Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
• Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.
• Identification of a phosphodiesterase that converts inositol cyclic 1:2-phosphate to inositol 2-phosphate.
• Mammalian cells that express Bacillus cereus phosphatidylinositol-specific phospholipase C have increased levels of inositol cyclic 1:2-phosphate, inositol 1-phosphate...
• Inositol phosphate biochemistry.
• The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular tran...
• Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments.
• The perturbation of thrombin binding to human platelets by anions.
• The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.
• Binding of the products of prothrombin activation to human platelets.
• Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone.
• The measurement of thrombin in clotting blood by radioimmunoassay.
• Editorial: Why aspirin?
• Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin.
• Evidence for a single class of thrombin-binding sites of human platelets.
• The binding of human and bovine thrombin to human platelets.
• Acetylation of prostaglandin synthase by aspirin.

Schools

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• Washington Center School of Medicine

• Clinical Center At The Nih

• Mass Gen Hospital

Doctors Specialties

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• Internal Medicine
• Hematology

Accepted Insurances

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Awards

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• Elected Member
• Whos Who in Medicine and Healthcare

Education

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• National Institutes of Health Clinical Center
• Massachusetts General Hospital
• Washington University School of Medicine in St. Louis

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