Professor, Pathology and Laboratory Medicine, UCLA School of Medicine
Pathology
Dr. Peter Tontonoz, MD
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Peter Tontonoz works in the field of Pathology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He received awards:"Elected Member" and "Investigator". Doctor Peter Tontonoz, MD is also published. He has 102 publications published. The lastest publication: "Palmoplantar Keratoderma in Slurp2-Deficient Mice.'
Publications
- The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis.
- Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.
- The orphan nuclear receptor nur77 is a determinant of myofiber size and muscle mass in mice.
- Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.
- Estrogen Receptor (ER)α-regulated Lipocalin 2 Expression in Adipose Tissue Links Obesity with Breast Cancer Progression.
- Genetic architecture of insulin resistance in the mouse.
- The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.
- The LXR-Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice.
- SUMOylation Places LRH-1 in PROXimity to Lipid Metabolism.
- Eosinophils in fat: pink is the new brown.
- Transgenic Expression of Dominant-Active IDOL in Liver Causes Diet-Induced Hypercholesterolemia and Atherosclerosis in Mice.
- Liver X receptors in lipid metabolism: opportunities for drug discovery.
- Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
- The GPIHBP1-LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries.
- Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.
- Palmoplantar Keratoderma along with Neuromuscular and Metabolic Phenotypes in Slurp1-Deficient Mice.
- LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition.
- The nuclear receptor LXRα controls the functional specialization of splenic macrophages.
- Reciprocal regulation of hepatic and adipose lipogenesis by liver x receptors in obesity and insulin resistance.
- Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.
- Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.
- Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPAR? Specifies Lipid Storage versus Thermogenic Gene Programs.
- Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice.
- Vestigial-like 3 is an inhibitor of adipocyte differentiation.
- Metabolism: Drug discovery goes for a swim.
- Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization.
- Feedback Regulation of Cholesterol Uptake by the LXR-IDOL-LDLR Axis.
- LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.
- The number of x chromosomes causes sex differences in adiposity in mice.
- Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.
- Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon.
- SIRT1 Regulation-It Ain't All NAD.
- Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice.
- Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.
- FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.
- GPIHBP1, an endothelial cell transporter for lipoprotein lipase.
- The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.
- The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
- TLE3 is a dual-function transcriptional coregulator of adipogenesis.
- Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.
- Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.
- Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.
- LXR deficiency confers increased protection against visceral Leishmania infection in mice.
- Licensing PPAR? to work in macrophages.
- LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression.
- Genome-wide association studies identify new targets in cardiovascular disease.
- Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.
- Liver x receptor signaling pathways and atherosclerosis.
- The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.
- The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
- Peroxisome proliferator-activated receptor gamma dances with different partners in macrophage and adipocytes.
- Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.
- Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
- Negative regulation of Hedgehog signaling by liver X receptors.
- LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
- Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt.
- The small molecule phenamil induces osteoblast differentiation and mineralization.
- A Nurr1 pathway for neuroprotection.
- T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.
- Before they were fat: adipocyte progenitors.
- TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.
- Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.
- The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.
- Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors.
- Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow.
- HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.
- Integration of metabolism and inflammation by lipid-activated nuclear receptors.
- LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
- Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation.
- ApoE promotes the proteolytic degradation of Abeta.
- Fat and beyond: the diverse biology of PPARgamma.
- Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and ...
- Adopting new orphans into the family of metabolic regulators.
- Endocrine functions of adipose tissue.
- N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
- Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
- Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.
- Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle.
- The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.
- STAMPing out Inflammation.
- Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2.
- A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor.
- A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.
- The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages.
- NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
- Phosphorylation of the liver X receptors.
- Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.
- The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis.
- Liver X receptors as integrators of metabolic and inflammatory signaling.
- Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia.
- Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.
- SUMOylation and PPARgamma: wrestling with inflammatory signaling.
- Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
- A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
- Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.
- Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
- Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists.
- PPARs in atherosclerosis: the clot thickens.
- Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
- Palmoplantar Keratoderma in Slurp2-Deficient Mice.
- Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet.
Schools
Harvard Medical School
University Ca San Diego Med Center
Doctors Specialties
- Pathology
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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University of California San Diego -
Harvard Medical School
Hospital
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Ronald Reagan UCLA Medical Center
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