Clinical Fellow in Surgery, Brigham and Women's Hospital

General Surgery

Doctor Peleg M. Horowitz, MD practices General Surgery. Peleg Horowitz is a published MD as well. He has 35 publications published. The latest was: High hydrostatic pressure can reverse aggregation of protein folding intermediates and facilitate acquisition of native structure.

Publications

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• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.
• Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.
• Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
• Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro.
• A possible link between astrocyte activation and tau nitration in Alzheimer's disease.
• Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro.
• N-terminal fragments of tau inhibit full-length tau polymerization in vitro.
• Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.
• Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.
• Self-assembly of Abeta(1-42) into globular neurotoxins.
• The 4,4'-dipyridyl disulfide-induced formation of GroEL monomers is cooperative and leads to increased hydrophobic exposure.
• The binding of bis-ANS to the isolated GroEL apical domain fragment induces the formation of a folding intermediate with increased hydrophobic surface not observed in ...
• Rhodanese as a thioredoxin oxidase.
• High hydrostatic pressure can reverse aggregation of protein folding intermediates and facilitate acquisition of native structure.
• Reversible oligomerization and denaturation of the chaperonin GroES.
• Residual structure in urea-denatured chaperonin GroEL.
• Mutation in the interdomain tether influences the stability and refolding of the enzyme rhodanese.
• Photoincorporation of 4,4'-bis(1-anilino-8-naphthalenesulfonic acid) into the apical domain of GroEL: specific information from a nonspecific probe.
• The sulfurtransferase activity and structure of rhodanese are affected by site-directed replacement of Arg-186 or Lys-249.
• Mutations of noncatalytic sulfhydryl groups influence the stability, folding, and oxidative susceptibility of rhodanese.
• The chaperonin assisted and unassisted refolding of rhodanese can be modulated by its N-terminal peptide.
• Physical characterization of a reactivatable liposome-bound rhodanese folding intermediate.
• GroEL and GroES increase the specific enzymatic activity of newly-synthesized rhodanese if present during in vitro transcription/translation.
• A chaperone-mimetic effect of serum albumin on rhodanese.
• Analysis of the perturbation of phospholipid model membranes by rhodanese and its presequence.
• Intrinsic fluorescence of succinyl-CoA synthetase and four tryptophan mutants. Tryptophan 76 and tryptophan 248 of the beta-subunit are responsive to CoA binding.
• Shielding of tryptophan residues of avidin by the binding of biotin.
• Studies of the secondary structures of amelogenin from bovine tooth enamel.
• Detection of energy transfer between tryptophan residues in the tubulin molecule and bound bis(8-anilinonaphthalene-1-sulfonate), an inhibitor of microtubule assembly,...
• Detection, characterization, and quenching of the intrinsic fluorescence of bovine heart cytochrome c oxidase.
• Bis(8-anilinonaphthalene-1-sulfonate) as a probe for tubulin decay.
• Differential binding of the fluorescent probe 8-anilinonaphthalene-2-sulfonic acid to rhodanese catalytic intermediates.
• A study of the quenching of the intrinsic fluorescence of succinyl-CoA synthetase from Escherichia coli by acrylamide, iodide, and coenzyme A.
• Fluorescence detection of increased local flexibility induced by coenzyme A in succinyl-coA synthetase from Escherichia coli.

Schools

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• Northwestern Center Feinberg School of Medicine

Doctors Specialties

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• Neurosurgery
• General Surgery

Accepted Insurances

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Hospital

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• Brigham and Women's Hospital

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