Physician

Internal Medicine

Dr. Paulos Berhanu practices Internal Medicine. He graduated from Loma Linda University School of Medicine. He has 1 awards "Fellow (FACE)". Paulos Berhanu has written publications. He has 38 publications published with PubMed. The lastest paper is: 'Insulin signal transduction by a mutant human insulin receptor lacking the NPEY sequence. Evidence for an alternate mitogenic signaling pathway that is independent of ...'

Publications

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• Retinopathy in patients of Tikur Anbessa Hospital diabetic clinic.
• Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.
• Profile of coronary artery risk factors in Ethiopian diabetic patients.
• Insulin signal transduction by a mutant human insulin receptor lacking the NPEY sequence. Evidence for an alternate mitogenic signaling pathway that is independent of ...
• Insulin internalization in the absence of the insulin receptor tyrosine kinase domain is insufficient for mediating intracellular biological effects.
• Protein tyrosine phosphatase 1B interacts with the activated insulin receptor.
• The amino acid sequence GPLY is not necessary for normal endocytosis of the human insulin receptor B isoform.
• Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.
• Photoaffinity labeling of insulin receptors in viable cultured human lymphocytes. Demonstration of receptor shedding and degradation.
• Internalization and molecular processing of insulin receptors in isolated rat adipocytes.
• Internalization and intracellular processing of insulin and insulin receptors in adipocytes.
• Effects of insulin and insulin-like agents on the glucose transport system of cultured human fibroblasts.
• Insulin-stimulated glucose transport in cultured fibroblasts from normal and noninsulin-dependent (type II) diabetic human subjects.
• Metabolism of photoaffinity-labeled insulin receptors by adipocytes. Role of internalization, degradation, and recycling.
• Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing.
• Degradation of insulin receptors in rat adipocytes.
• Structural differences between insulin receptors in the brain and peripheral target tissues.
• Epidermal growth factor-urogastrone receptor: selective alteration in simian virus 40 transformed mouse fibroblasts.
• Insulin receptors on cultured hypothalamic cells: functional and structural differences from receptors on peripheral target cells.
• Insulin-stimulated glucose transport and insulin internalization share a common postbinding step in adipocytes.
• Effects of metalloendoprotease inhibitors on insulin binding, internalization and processing in adipocytes.
• Insulin internalization and degradation in adipocytes from normal and type II diabetic subjects.
• Adipocyte insulin receptor. Generation of a cryptic domain of the alpha-subunit during internalization of hormone-receptor complexes.
• Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy.
• Chymotrypsin substrate analogues inhibit endocytosis of insulin and insulin receptors in adipocytes.
• Replacement of the human insulin receptor transmembrane and cytoplasmic domains by corresponding domains of the oncogene product v-ros leads to accelerated internaliza...
• Insulin downregulates the steady-state level of its receptor's messenger ribonucleic acid.
• The NPEY sequence is not necessary for endocytosis and processing of insulin-receptor complexes.
• Selective reduction in receptors for epidermal growth factor-urogastrone in chemically transformed tumorigenic Syrian hamster embryo fibroblasts.
• Effect of pioglitazone in combination with insulin therapy on glycaemic control, insulin dose requirement and lipid profile in patients with type 2 diabetes previously...
• Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.
• Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed.
• Profile of diabetic ketoacidosis in a predominantly African American urban patient population.
• Analysis of serum lipids and lipoproteins in Ethiopian diabetic patients.
• Human insulin receptor juxtamembrane domain independent insulin signaling.
• Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus.
• Effects of pioglitazone on lipid and lipoprotein profiles in patients with type 2 diabetes and dyslipidaemia after treatment conversion from rosiglitazone while contin...

Schools

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• Loma Linda University

• Johns Hopkins Hospital

• L a Co Usc Med Center

• Loma Linda University Med Center

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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Awards

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• Fellow (FACE)

Education

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• Johns Hopkins University
• Loma Linda University
• University of Southern California - LAC+USC Medical Center
• Loma Linda University School of Medicine

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