Professor of Pediatrics, University Wisc
Pediatric Hematology & Oncology
Dr. Paul M. Sondel, MD
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Paul Sondel practices Pediatric Hematology & Oncology. He went to Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care He over the years received 4 awards: "America's Top Doctors", "America's Top Doctors for Cancer", "Elected Member" and "Whos Who in Medicine and Healthcare". Dr. Paul M. Sondel has written publications. He has 40 publications published with PubMed. The lastest paper is: 'NK Cell-based Immunotherapies in Pediatric Oncology.'
Publications
- NK Cell-based Immunotherapies in Pediatric Oncology.
- Rhamnose Glycoconjugates for the Recruitment of Endogenous Anti-Carbohydrate Antibodies to Tumor Cells.
- Antitumor effects of anti-CD40/CpG immunotherapy combined with gemcitabine or 5-fluorouracil chemotherapy in the B16 melanoma model.
- Phase I trial of fenretinide delivered orally in a novel organized lipid complex in patients with relapsed/refractory neuroblastoma: A report from the new approaches t...
- Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the Hu14.18 antibody increases intratumoral CD8+ T...
- Intratumoral Delivery of Low Doses of Anti-CD40 mAb Combined With Monophosphoryl Lipid A Induces Local and Systemic Antitumor Effects in Immunocompetent and T Cell-Def...
- Enhancement of the anti-melanoma response of Hu14.18K322A by + CpG.
- An optimized multi-parameter flow cytometry protocol for human T regulatory cell analysis on fresh and viably frozen cells, correlation with epigenetic analysis, and c...
- T-cell-independent Antitumor Effects of CD40 Ligation.
- Intratumoral hu14.18-IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention.
- Phase II trial of hu14.18-IL2 for patients with metastatic melanoma.
- Phase II Study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: A report from the Child...
- Soluble interleukin-2 receptor ? activation in a Children's Oncology Group randomized trial of interleukin-2 Therapy for Pediatric Acute Myeloid Leukemia.
- Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy.
- Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface.
- Suppression of T-Cell Expansion by Melanoma is Exerted on Resting Cells.
- Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting.
- Clinical Cancer Therapy by NK Cells via Antibody-Dependent Cell-Mediated Cytotoxicity.
- Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in mice.
- Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.
- Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study.
- Anti-GD2 Strategy in the Treatment of Neuroblastoma.
- Immunogenicity of the hu14.18-IL2 immunocytokine molecule in adults with melanoma and children with neuroblastoma.
- Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma.
- Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia.
- Highlights of the First International "Immunotherapy in Pediatric Oncology: Progress and Challenges" Meeting.
- Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
- Phase I study of ch14.18 with granulocyte-macrophage colony-stimulating factor and interleukin-2 in children with neuroblastoma after autologous bone marrow transplant...
- Immunotherapy for pediatric cancer.
- A phase I study of immunization using particle-mediated epidermal delivery of genes for gp100 and GM-CSF into uninvolved skin of melanoma patients.
- In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages.
- Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects.
- CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro.
- Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody.
- Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapy.
- Safety of interleukin-12 gene therapy against cancer: a murine biodistribution and toxicity study.
- Pleasant memories: remembering immune protection while forgetting about graft-versus-host disease.
- Determination of peak serum levels and immune response to the humanized anti-ganglioside antibody-interleukin-2 immunocytokine.
- Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.
Schools
Harvard Medical School
University Minn Hosps
University Wisc Hospital
University Of Wisconsin Madison
Doctors Specialties
- Pediatrics
- Pediatric Hematology
- Oncology
Accepted Insurances
- Choice Plus POS II
- Anthem Blue Cross Blue Shield HMO
- Anthem Blue Cross Blue Shield PPO
- Blue Preferred Plus POS
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Group Employees PPO
- Blue Cross Accord
- Great West Healthcare-Cigna PPO
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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University of Wisconsin -
University of Minnesota at Fairview -
Harvard Medical School
Hospital
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Meriter UnityPoint Health -
University of Wisconsin Hospital and Clinics
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