Associate Professor, Pediatrics, Washington University in St. Louis School of Medicine

Pediatric Cardiology

Doctor Patrick Y. Jay, MD works in the field of Pediatric Cardiology. He attended Washington University School of Medicine in St. Louis. Patrick Y. Jay has written publications. He has 44 publications published with PubMed. The lastest paper is: 'Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.'

Publications

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• The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.
• Reprogramming the conduction system: Onward toward a biological pacemaker.
• Rhythm genes sing more than one tune: noncanonical functions of cardiac ion channels.
• The maternal-age-associated risk of Congenital heart disease is modifiable.
• Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated Cardiomyopathy in a mouse model.
• Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
• A Single Misstep in Cardiac Development Explains the Co-Occurrence of Tetralogy of Fallot and Complete Atrioventricular Septal Defect in Down Syndrome.
• Tissue Doppler Septal Tei Index Indicates Severity of Illness in Pediatric Patients With Congestive Heart Failure.
• Association of genes with physiological functions by comparative analysis of pooled expression microarray data.
• Enhanced Cardiac PI3K? Signaling Mitigates Arrhythmogenic Electrical Remodeling in Pathological Hypertrophy and Heart Failure.
• GATA4 Deficiency Impairs Ovarian Function in Adult Mice.
• Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.
• Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated Cardiomyopathy.
• Heterogeneity of genetic modifiers ensures normal cardiac development.
• Loss of glypican-3 function causes growth factor-dependent Defects in cardiac and coronary vascular development.
• Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
• HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated Cardiomyopathy.
• Genetic wiring diagram of the cardiac conduction system.
• PI3K(p110alpha) inhibitors as anti-cancer agents: minding the Heart.
• Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung Defects.
• Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic Cardiomyopathy.
• Dilated Cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.
• Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes.
• Absence of Msx2 does not affect cardiac conduction or rescue conduction Defects associated with Nkx2-5 mutation.
• Function follows form: cardiac conduction system Defects in Nkx2-5 mutation.
• Transcriptional regulation of cardiac conduction system development: 2004 FASEB cardiac conduction system minimeeting, Washington, DC.
• Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.
• Elucidating the molecular and genetic interactions responsible for Congenital heart disease.
• Forces in cell locomotion.
• Insights into the Genetic Structure of Congenital Heart Disease from Human and Murine Studies on Monogenic Disorders.
• Ex vivo, microelectrode analysis of conduction through the AV node of wild-type and Nkx2-5 mutant mouse Hearts as guided by a Cx40-eGFP transgenic reporter.
• A mechanical function of myosin II in cell motility.
• Capping protein levels influence actin assembly and cell motility in dictyostelium.
• Studies of mechanical aspects of amoeboid locomotion.
• Surface particle transport mechanism independent of myosin II in Dictyostelium.
• Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.
• A mouse model of congenital heart disease: cardiac Arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
• Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
• Molecular genetics of Congenital diaphragmatic defects.
• The 16th Asian Pacific Congress of Cardiology (APCC).
• Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2-5.
• Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans.
• Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy.

Schools

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• Washington Center School of Medicine

• Chldn39s Hospital

Procedures Preformed

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• Cardiac Imaging

Conditions Treated

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• Arrhythmias (incl. Atrial Fibrillation)
• Cardiomegaly
• Cardiomyopathy
• Coarctation of the Aorta
• View All

Doctors Specialties

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• Pediatric Cardiology

Accepted Insurances

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Education

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• Boston Children's Hospital
• Washington University School of Medicine in St. Louis

Hospital

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• St. Louis Children's Hospital

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