Professor, Critical Care Medicine, University of Pittsburgh School of Medicine
Pediatrics
Dr. Patrick M. Kochanek, MD
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Patrick Kochanek works in the field of Pediatrics. He went to University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10 in research and 19 in primary care medicine He over the years received 1 awards: "Fellow (FCCM)". Patrick M. Kochanek, MD is a published physician. He published 99 publications, including: 'Ultrastructure of diaschisis lesions following traumatic brain injury.'
Publications
- Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.
- Probenecid and N-acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.
- Ultrastructure of diaschisis lesions following traumatic brain injury.
- Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
- 20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Card...
- Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion.
- Acute CSF interleukin-6 trajectories after TBI: Associations with neuroinflammation, polytrauma, and outcome.
- It might be time to let cooler heads prevail after mild traumatic brain injury or concussion.
- Emerging therapies in traumatic brain injury.
- Patterns of multiorgan dysfunction after pediatric drowning.
- The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.
- Effect of Administration of Neuromuscular Blocking Agents in Children With Severe Traumatic Brain Injury on Acute Complication Rates and Outcomes: A Secondary Analysis...
- 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors.
- Role for mammalian chitinase 3-like protein 1 in traumatic brain injury.
- Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion.
- Unique Brain Region-Dependent Cytokine Signatures After Prolonged Hypothermic Cardiac Arrest in Rats.
- Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.
- Finding a faster and safer way to "catch a cold" after cardiac arrest: We may be getting closer.
- A mitochondrial pathway for biosynthesis of lipid mediators.
- Blood Brain Barrier is Impermeable to Solutes and Permeable to Water after Experimental Pediatric Cardiac Arrest.
- Serum amyloid A is increased in children with abusive head trauma: A gel-based proteomic analysis.
- Hemorrhagic shock shifts the serum cytokine profile from pro-to anti-inflammatory after experimental traumatic brain injury in mice.
- Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI.
- IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study.
- Authors' Response to Letter to the Editor, "Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease - A Case Report"
- Cerebrospinal Fluid Mitochondrial DNA - A Novel DAMP in Pediatric Traumatic Brain Injury.
- Regional TNFα mapping in the brain reveals the striatum as a neuroinflammatory target after ventricular fibrillation cardiac arrest in rats.
- Interleukin 6 and apolipoprotein e as predictors of acute brain dysfunction and survival in critical care patients.
- Will the next breakthrough for neuroprotection after cardiac arrest come out of thin air?
- Making an IMPACT in traumatic brain injury research.
- Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental pediatric cardiac arrest.
- Minocycline attenuates brain tissue levels of TNF-α produced by neurons after prolonged hypothermic cardiac arrest in rats.
- Extracorporeal versus conventional cardiopulmonary resuscitation after ventricular fibrillation cardiac arrest in rats: a feasibility trial.
- Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice.
- Effect of a Single Dose of Propofol and Lack of Dextrose Administration in a Child With Mitochondrial Disease: A Case Report.
- Regional Brain Injury on Conventional and Diffusion Weighted MRI is Associated with Outcome After Pediatric Cardiac Arrest.
- Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway.
- Role of CD73 in Renal Sympathetic Neurotransmission in the Mouse Kidney.
- Therapeutic Hypothermia Decreases Phenytoin Elimination in Children with Traumatic Brain Injury.
- Influence of ATP-Binding Cassette Polymorphisms on Neurological Outcome After Traumatic Brain Injury.
- Temperature management in neurological and neurosurgical intensive care units.
- Pediatric traumatic brain injury in 2012: the year with new guidelines and common data elements.
- Effect of hyperoxia on resuscitation of experimental combined traumatic brain injury and hemorrhagic shock in mice.
- Screening of Biochemical and Molecular Mechanisms of Secondary Injury and Repair in the Brain after Experimental Blast-Induced Traumatic Brain Injury in Rats.
- Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice.
- Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent.
- MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice.
- Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat.
- Therapeutic Hypothermia for Refractory Status Epilepticus in a Child with Malignant Migrating Partial Seizures of Infancy and SCN1A Mutation: A Case Report.
- Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury.
- SEVERE BRIEF PRESSURE CONTROLLED HEMORRHAGIC SHOCK AFTER TRAUMATIC BRAIN INJURY EXACERBATES FUNCTIONAL DEFICITS AND LONG-TERM NEUROPATHOLOGICAL DAMAGE IN MICE.
- Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations.
- Cerebrospinal Fluid Levels of High-Mobility Group Box 1 and Cytochrome C Predict Outcome after Pediatric Traumatic Brain Injury.
- Reviewer thank you.
- Mass critical care for children: Implications for adult critical care.
- Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome.
- The Utility of Near Infrared Spectroscopy in Detecting Intracranial Hemorrhage in Children.
- Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.
- Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.
- "Lost in translation?" Noninvasive cerebral monitoring after cardiac arrest.
- Unmasking Sex-Based Disparity in Neuronal Metabolism.
- Mitochondrial Injury after Mechanical Stretch of Cortical Neurons in vitro: Biomarkers of Apoptosis and Selective Peroxidation of Anionic Phospholipids.
- Cardiac Arrest and Therapeutic Hypothermia Interaction with Isoform-specific Cytochrome P450 Drug Metabolism.
- Expression of the 2'',3''-cAMP-adenosine pathway in astrocytes and microglia.
- Autophagy in acute brain injury: Feast, famine, or folly?
- A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy.
- Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations.
- Cerebrovascular response in children following severe traumatic brain injury.
- Relationship between hyperglycemia and outcome in children with severe traumatic brain injury.
- Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury.
- CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI.
- Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorr...
- Normoxic versus hyperoxic resuscitation in pediatric asphyxial cardiac arrest: effects on oxidative stress.
- Pediatric Critical Care Medicine: re-tooling to accommodate growth and success while preserving excellence.
- Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs.
- Fever control and application of hypothermia using intravenous cold saline.
- Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury.
- Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxides.
- Brain-systemic temperature gradient is temperature-dependent in children with severe traumatic brain injury.
- Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs.
- Intracranial pressure-monitoring systems in children with traumatic brain injury: Combining therapeutic and diagnostic tools.
- Titrating oxygen during and after cardiopulmonary resuscitation.
- How I cool children in neurocritical care.
- Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.
- Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice.
- Neurological sequelae of 2009 influenza A (H1N1) in children: a case series observed during a pandemic.
- Influence of PARP-1 polymorphisms in patients after traumatic brain injury.
- Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues.
- A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest.
- Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest.
- Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemody...
- Relationship between increases in pancreatic enzymes and cerebral events in children after traumatic brain injury.
- Postcardiac arrest syndrome: focus on the brain.
- Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury.
- Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats.
- Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury.
- Pediatric neurointensive care: 2008 update for the Rogers' Textbook of Pediatric Intensive Care.
- Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death.
Schools
University Of ChicagoThe Pritzker School Of Medicine
University Calif San Diego
Chldns Hospital National Med Center
Doctors Specialties
- Pediatric Critical Care Medicine
- Pediatrics
Accepted Insurances
Awards
- Fellow (FCCM)
Education
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Children's National Medical Center - George Washington University -
University of California San Diego -
University of Chicago Pritzker School of Medicine
Hospital
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UPMC Presbyterian Shadyside
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