Physician
Preventive Medicine
Dr. Patrick J. Stover, MD
|
|
Give Review
Dr. Patrick J. Stover practices Preventive Medicine. He went to St. George's University School of Medicine. Patrick Stover is a published doctor and has 87 publications published. The lastest was: 'Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.'
Publications
- MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.
- Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.
- Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.
- Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.
- Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
- Serine Hydroxymethyltransferase anchors the de novo thymidylate synthesis pathway to the nuclear lamina for DNA synthesis.
- Competition between Sumoylation and Ubiquitylation of Serine Hydroxymethyltransferase 1 Determines its Nuclear Localization and its Accumulation in the Nucleus.
- Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
- Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.
- Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.
- Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
- Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of apc(min)-mediated intestinal cancer risk.
- Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.
- One-carbon metabolism-genome interactions in folate-associated pathologies.
- A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair.
- Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1.
- Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.
- Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.
- 5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.
- SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis.
- Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice.
- Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions.
- Mouse models to elucidate mechanisms of folate-related cancer pathologies.
- Folate-mediated one-carbon metabolism.
- Convergence of genetic, nutritional and inflammatory factors in gastrointestinal cancers.
- A ferritin-responsive internal ribosome entry site regulates folate metabolism.
- Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.
- Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.
- Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.
- Inhibition of 5,10-methenyltetrahydrofolate synthetase.
- Methenyltetrahydrofolate synthetase is a high-affinity catecholamine-binding protein.
- Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase.
- Nutrition and developmental biology--implications for public health.
- Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma.
- Influence of human genetic variation on nutritional requirements.
- Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
- Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication.
- Physiology of folate and vitamin B12 in health and disease.
- Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus.
- Nutritional genomics.
- New paradigms for nutrient control of genome translation.
- Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation.
- Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers.
- Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.
- Bringing individuality to public health recommendations.
- Securing the future of nutritional sciences through integrative graduate education.
- Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
- Mthfs is an Essential Gene in Mice and a Component of the Purinosome.
- Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.
- Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase.
- Vitamin B12 and older adults.
- PhenX: a toolkit for interdisciplinary genetics research.
- High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.
- Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
- Human nutrition and genetic variation.
- No association between cSHMT genotypes and the risk of breast cancer in the Nurses'' Health Study.
- Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene.
- 5-Formyltetrahydrofolate regulates homocysteine remethylation in human neuroblastoma.
- Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
- Mimosine is a cell-specific antagonist of folate metabolism.
- Purification and properties of a folate-catabolizing enzyme.
- Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein.
- Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers.
- Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis.
- Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism.
- New perspectives on folate catabolism.
- Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification.
- Biomarkers of folate status in NHANES: a roundtable summary.
- Biomarkers of vitamin B-12 status in NHANES: a roundtable summary.
- Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathway.
- Escherichia coli serine hydroxymethyltransferase. The role of histidine 228 in determining reaction specificity.
- Evidence for the accumulation of a stable intermediate in the nonenzymatic hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate.
- Enzymatic mechanism for the hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate by serine hydroxymethyltransferase.
- Synthesis of (6S)-5-formyltetrahydropteroyl-polyglutamates and interconversion to other reduced pteroylpolyglutamate derivatives.
- 5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase.
- Treatment of pyoderma gangrenosum with cyclosporine: results in seven patients.
- Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.
- A partnership with vendors.
- Primary structure and tetrahydropteroylglutamate binding site of rabbit liver cytosolic 5,10-methenyltetrahydrofolate synthetase.
- Folylpoly-gamma-glutamate synthetase.
- Evidence that 5-formyltetrahydropteroylglutamate has a metabolic role in one-carbon metabolism.
- Purification and properties of rabbit liver 5,10-methenyltetrahydrofolate synthetase.
- Diffraction grade crystals of Escherichia coli serine hydroxymethyltransferase.
- The metabolic role of leucovorin.
- Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.
- Tracking skin integrity: a template for hospital and vendor collaboration.
Doctors Specialties
- Occupational Medicine
- Preventive Occupational Medicine
- Preventive Medicine
Accepted Insurances
Education
-
University of Michigan School of Public Health -
St. George's University School of Medicine
Helpful Reviews
Similar Doctors
|
|
Dr. Deborah L. Duncan, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Heidi M. Bauer, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Donald W. Lawrenchuk, MD |
|
|
Dr. Leroy A. Waite Jr., DO
This Doctor is OpenDoctor Recommended.
|