Physician

Medical Genetics

Dr. Norihiko Kawamata, MD

Norihiko Kawamata, MD works in the field of Medical Genetics. Norihiko Kawamata is a published doctor and has 83 publications published. The lastest was: 'P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833.'

Publications

Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.
Genetic differences between Asian and Caucasian chronic lymphocytic leukemia.
Epstein-Barr virus-associated T-cell acute lymphoblastic leukaemia.
Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the ...
A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4.
Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms.
Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors.
[Zygomycosis: two case reports and review of reported cases in the literature in Japan].
Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis.
Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.
Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow.
Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders.
Discovery of epigenetically masked tumor suppressor genes in endometrial cancer.
ERCC5 is a novel biomarker of ovarian cancer prognosis.
Chronic phase of ETV6-ABL1 positive CML responds to imatinib.
Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray.
Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray.
Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence...
Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.
Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas.
Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.
Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.
Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and...
Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.
High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray.
Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.
SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.
Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.
Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic le...
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.
Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseu...
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo.
Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer.
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.
Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genot...
Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray.
Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia.
2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth.
SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells.
Molecular analysis of tumor suppressor genes, Rb, p53, p16INK4A, p15INK4B and p14ARF in natural killer cell neoplasms.
Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas.
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.
P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833.
Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias.
Molecular analysis of a family of cyclin-dependent kinase inhibitor genes (p15/MTS2/INK4b and p18/INK4c) in non-small cell lung cancers.
Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias.
Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas.
Point mutations of the Mxil gene are rare in prostate cancers.
Detection of chimaeric transcripts of the immunoglobulin heavy chain and BCL6 genes by reverse-transcriptase polymerase chain reaction in B-cell non-Hodgkin''s lymphomas.
Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.
Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a KrÃƒÂ¼ppel-like zinc-finger protein.
Variant translocation of the BCL6 gene to immunoglobulin kappa light chain gene in B-cell lymphoma.
All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells: distinct expression of thrombomodu...
p27/Kip1 mutation found in breast cancer.
Alterations of the p15, p16,and p18 genes in osteosarcoma.
Dlk1 in normal and abnormal hematopoiesis.
Dominant-negative mechanism of leukemogenic PAX5 fusions.
mdm-2 oncogene expression in non-Hodgkin's lymphomas.
A novel mutation that leads to a congenital factor XI deficiency in a Japanese family.
Identification of marker genes including RUNX3 (AML2) that discriminate between different myeloproliferative neoplasms and normal individuals.
Recognition DNA sequence of a novel putative transcription factor, BCL6.
Biallelic DNA rearrangements and deletions within the BCL-6 gene in B-cell non-Hodgkin''s lymphoma.
DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies.
Methylation analysis of asparagine synthetase gene in acute lymphoblastic leukemia cells.
[Mantle cell lymphoma with marked lymphocytosis at the presentation and with discordant morphology between the lymph node and peripheral blood].
Two Burkitt-type lymphoma/leukemia-derived cell lines presenting 3q27 translocations and immunoglobulin/BCL6 chimeric transcripts.
The organization of the BCL6 gene.
Determination of a common clonal origin of gastric and pulmonary mucosa-associated lymphoid tissue lymphomas presenting five years apart.
A case of chronic lymphocytic leukaemia with myeloid associated antigen.
[Primary splenic lymphoma with hypoplastic bone marrow].
[Clinical effects of combination therapy with cefozopran and tobramycin for severe infections in patients with hematologic diseases].
[Primary pulmonary non-Hodgkin''s lymphoma in a patient with dermatomyositis].
Treatment with granulocyte colony-stimulating factor for pneumonia in a patient with a variant form of X-linked chronic granulomatous disease.
[Autoimmune hemolytic anemia].
Percutaneous intracavitary antifungals for a patient with pulmonary aspergilloma; with a special reference to in vivo efficacies and in vitro susceptibility results.

Doctors Specialties

Medical Genetics

Accepted Insurances

Education

Cedars-Sinai Medical Center
Tokyo Medical and Dental University

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