Professor, Pathology, UCSD School of Medicine
Pathology
Dr. Nissi M. Varki, MD
Nissi M. Varki practices Pathology. Dr. Nissi M. Varki is a published doctor. He published 99 publications, including: 'Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.'
Publications
- Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.
- Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens.
- The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expans...
- A red meat-derived glycan promotes inflammation and cancer progression.
- Host adaptation of a bacterial toxin from the human pathogen salmonella typhi.
- Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) Is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
- Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.
- Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
- Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGF-1 Receptor.
- Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies.
- Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates.
- Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor.
- Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proest...
- A phenotype survey of thirty-six mutant mouse strains with gene targeted defects in glycosyltransferases or glycan-binding proteins.
- Using unfixed, frozen tissues to study natural mucin distribution.
- Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Mechanisms underlying gastrointestinal Incorporation of the non-human sialic acid Xeno-autoantigen, N-gly...
- Evolution of Siglec-11 and Siglec-16 Genes in Hominins.
- Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
- Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology.
- The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.
- Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium.
- A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome.
- Molecular basis of metastasis.
- Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.
- Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression.
- alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.
- Diversity in cell surface sialic acid presentations: implications for biology and disease.
- Expression of the human copper influx transporter 1 in normal and malignant human tissues.
- L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest.
- A human-specific gene in microglia.
- Combining Parenting and a Science Career.
- Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies.
- Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.
- Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients.
- Human-specific regulation of alpha 2-6-linked sialic acids.
- Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
- Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, i...
- Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
- Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans.
- Corrigendum: involvement of a non-human sialic Acid in human cancer.
- Involvement of a Non-Human Sialic Acid in Human Cancer.
- Tumor infiltrating B-cells are increased in prostate cancer tissue.
- Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase.
- Deletion of JAM-C, a candidate gene for heart defects in Jacobsen syndrome, results in a normal cardiac phenotype in mice.
- ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.
- Effects of ACE2 inhibition in the post-myocardial infarction heart.
- SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
- Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.
- Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.
- Human-specific expression of Siglec-6 in the placenta.
- N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.
- System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution.
- A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination.
- Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection.
- RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.
- Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease.
- The Ashwell receptor mitigates the lethal coagulopathy of sepsis.
- B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.
- Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis.
- Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection.
- Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid.
- Tumor promotion by caspase-resistant retinoblastoma protein.
- Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas.
- The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on uveal melanoma rabbit model.
- Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for m...
- IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart.
- Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium.
- Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.
- A second uniquely human mutation affecting sialic acid biology.
- Pictures in molecular medicine: three-dimensional visualization of intravascular tumor cells in mice.
- P-selectin, carcinoma metastasis and heparin: novel mechanistic connections with therapeutic implications.
- IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy.
- Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity.
- Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis.
- A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses.
- Ras activation in human breast cancer.
- Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin...
- Analysis of MLH1 and MSH2 expression in ovarian cancer before and after platinum drug-based chemotherapy.
- The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.
- Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs.
- Human intestinal epithelial cells express receptors for platelet-activating factor.
- Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium.
- Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.
- Chemokine receptor expression by human intestinal epithelial cells.
- Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials.
- De-N-acetyl-gangliosides in humans: unusual subcellular distribution of a novel tumor antigen.
- Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.
- P-selectin deficiency attenuates tumor growth and metastasis.
- Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma.
- Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy.
- Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow.
- Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy.
- An IgG monoclonal antibody against Dictyostelium discoideum glycoproteins specifically recognizes Fucalpha1,6GlcNAcbeta in the core of N-linked glycans. Localized expr...
- Expression and regulation of the neural cell adhesion molecule L1 on human cells of myelomonocytic and lymphoid origin.
- Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy.
- DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.
- Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing.
- Lymphocyte-mediated alopecia in C57BL/6 mice following successful immunotherapy for melanoma.
Doctors Specialties
- Pathology
Accepted Insurances
Education
-
Scripps Clinic -
Creighton University
Helpful Reviews
Similar Doctors
|
Dr. Jack D. Bui, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Stephen R. Carlson, MD |
|
|
Dr. Pamela D. Boswell, DO
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Howard S. Robin, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Scott R. Vandenberg, MD
This Doctor is OpenDoctor Recommended.
|