Physician

Hematology

Niramol Savaraj is an expert in the field of Hematology. He went to medical school at Medical College of Georgia. Dr. Niramol Savaraj is a published doctor. He published 47 publications, including: 'Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin.'

Publications

---

• Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin.
• Arginine deprivation in Cancer therapy.
• Combination of Arginine Deprivation with TRAIL Treatment as a Targeted-Therapy for Mesothelioma.
• Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.
• Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals.
• TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation.
• Sp1 Oscillation Is Involved in Copper Homeostasis Maintenance by Regulating hCtr1 Expression.
• The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma.
• Topoisomerase I inhibitors in the treatment of primary CNS Malignancies: an update on recent trends.
• Targeted cellular metabolism for Cancer chemotherapy with recombinant arginine-degrading enzymes.
• 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.
• The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines.
• Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.
• Mechanistic comparison of human high-affinity copper transporter 1-mediated transport between copper ion and cisplatin.
• Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins.
• Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia ...
• Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1.
• Topoisomerase I inhibitors for the treatment of brain tumors.
• Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation.
• Merkel cell Carcinomas.
• The roles of copper transporters in cisplatin resistance.
• Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose.
• Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors.
• Pegylated arginine deiminase: a novel antiCancer enzyme agent.
• Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver Cancers.
• Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated...
• Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development.
• Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma.
• Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies.
• Overcoming cisplatin resistance by mTOR inhibitor in lung Cancer.
• Redox regulation of matrix metalloproteinase gene family in small cell lung Cancer cells.
• Cyclosporine A, alpha-lnterferon and interleukin-2 following chemotherapy with BCNU, DTIC, cisplatin, and tamoxifen: a phase II study in advanced melanoma.
• Differential sensitivity to 2-deoxy-D-glucose between two Pancreatic cell lines correlates with GLUT-1 expression.
• Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells.
• Pilot study of estramustine added to radiosurgery and radiotherapy for treatment of high grade glioma.
• 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung Cancers in vivo.
• Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors.
• Overexpression of mutated MRP4 in cisplatin resistant small cell lung Cancer cell line: collateral sensitivity to azidothymidine.
• Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma ce...
• Recombinant leukocyte interferon, doxorubicin, and 5FUDR in patients with hepatocellular Carcinoma-A phase II trial.
• Design of antineoplastic agents based on the ''2-phenylnaphthalene-type'' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline d...
• Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).
• Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule.
• Phase II trial of Paclitaxel and Dacarbazine with filgrastim administration in advanced malignant melanoma.
• Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal Carcinoma.
• A phase I study of 4'-0-tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics.

Conditions Treated

---

• Anemia
• Breast Cancer
• Carcinoma in Situ
• Colorectal Cancer
• View All

Doctors Specialties

---

• Hematology
• Medical Oncology
• Oncology

Accepted Insurances

---

• Blue Cross Blue Shield
• CHAMPVA
• Cigna
• Commercial Insurance Company
• Emblem Health
• GEHA
• Humana
• Medicare MCR
• Tricare
• United Healthcare

Education

---

• Medical College of Georgia
• Jackson Memorial Hospital - Jackson Health System
• Mahidol University Faculty of Medicine

Hospital

---

• Miami Veterans Affairs Healthcare System

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Gotardo Rodrigues, MD This Doctor is OpenDoctor Recommended.
	Dr. Javier Barquet Sr., MD This Doctor is OpenDoctor Recommended.
	Dr. Gustavo L. Fernandez-Castro, MD This Doctor is OpenDoctor Recommended.
	Dr. Afzal H. Khan, MD This Doctor is OpenDoctor Recommended.
	Dr. Barry M. Kinzbrunner, MD This Doctor is OpenDoctor Recommended.
	Dr. Alexandra Stefanovic, MD This Doctor is OpenDoctor Recommended.
	Dr. Sarkis Y. Anac, MD This Doctor is OpenDoctor Recommended.
	Dr. Juan P. Alderuccio, MD This Doctor is OpenDoctor Recommended.
	Dr. Jennifer R. Chapman-Fredricks, MD This Doctor is OpenDoctor Recommended.
	Dr. Jorge H. Forcada, MD

---

Doctor Directory | TOS | twitter | FB | Angel | blog