Professor, Medicine, Perelman School of Medicine
Endocrinology
Dr. Mitchell A. Lazar, MD
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Mitchell Lazar practices Endocrinology. He graduated from Stanford University School of Medicine. Stanford University School of Medicine is a one of the best medicals schools. Stanford University School of Medicine is ranked 2/25 in Research/PrimaryCare. He received 3 awards: "Elected Member", "Whos Who in Medicine and Healthcare" and "Super Doctor". Dr. Mitchell A. Lazar is a published doctor and has 100 publications published. The lastest was: 'Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.'
Publications
- HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation.
- Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.
- Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo.
- Nutrient-sensing nuclear receptors coordinate autophagy.
- Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes.
- Integrator Regulates Transcriptional Initiation and Pause Release following Activation.
- Behavioral Changes and Dopaminergic Dysregulation in Mice Lacking the Nuclear Receptor Rev-erbα
- Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis.
- Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
- Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor.
- Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer.
- The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.
- Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ
- Cell-specific integration of nuclear receptor function at the genome.
- Pruning of the Adipocyte Peroxisome Proliferator-Activated Receptor γ Cistrome by Hematopoietic Master Regulator PU.1.
- Physiology. The health risk of obesity--better metrics imperative.
- Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3Â in vivo.
- A Novel Adipose-Specific Gene Deletion Model Demonstrates Potential Pitfalls of Existing Methods.
- Double SET point: G9a makes its mark in adipogenesis.
- Dissociating fatty liver and diabetes.
- Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome.
- Clocks, metabolism, and the epigenome.
- Physiology. De-meaning of metabolism.
- Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.
- Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract.
- Forming functional fat: a growing understanding of adipocyte differentiation.
- Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.
- Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification.
- Diet-induced lethality due to loss of HDAC3 in heart and skeletal muscle.
- A hormone sends instant messages to the genome.
- Human resistin: found in translation from mouse to man.
- Species-specific strategies underlying conserved functions of metabolic transcription factors.
- A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
- Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice.
- HDAC3 is a critical negative regulator of long-term memory formation.
- Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor al...
- Endogenous ligands for nuclear receptors: digging deeper.
- Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.
- GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
- The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo.
- Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
- E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.
- Propagation of adipogenic signals through an epigenomic transition state.
- Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages.
- Fingered for a fat fate.
- Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism.
- Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.
- Endoplasmic reticulum stress regulates adipocyte resistin expression.
- Brown fat in humans: turning up the heat on obesity.
- Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.
- Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.
- Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.
- New developments in adipogenesis.
- Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins.
- Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.
- Retinol saturase promotes adipogenesis and is downregulated in obesity.
- PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
- Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment.
- Developmental biology. How now, brown fat?
- Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
- Adipokines and the peripheral and neural control of energy balance.
- DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
- Bifunctional role of Rev-erbalpha in adipocyte differentiation.
- Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
- Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
- Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids.
- Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.
- PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.
- Central resistin induces hepatic insulin resistance via neuropeptide Y.
- Mechanisms of obesity-associated insulin resistance: many choices on the menu.
- A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.
- Sweet dreams for LXR.
- CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans.
- International Union of Pharmacology. LXIII. Retinoid X receptors.
- International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
- International Union of Pharmacology. LX. Retinoic acid receptors.
- The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1.
- Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.
- Loss of resistin improves glucose homeostasis in leptin deficiency.
- The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks.
- A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.
- HIV protease inhibitor-specific alterations in human adipocyte differentiation and metabolism.
- Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue.
- Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.
- The humoral side of insulin resistance.
- The many faces of PPARgamma.
- Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.
- PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1.
- Gaining weight: the Keystone Symposium on PPAR and LXR.
- Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter.
- The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.
- Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone.
- The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.
- Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.
- Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.
- Resistin is an inflammatory marker of atherosclerosis in humans.
- Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
- Activation of SOCS-3 by resistin.
- How obesity causes diabetes: not a tall tale.
Schools
Stanford University School Of Medicine
Brigham and Women39s Hospital
Massachusetts General Hospital
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
- Super Doctor
Education
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Brigham and Women's Hospital -
Massachusetts General Hospital -
Stanford University School of Medicine
Hospital
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Hospital of the University of Pennsylvania
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