Physician

Internal Medicine

Michael P. Bova, MD is an expert in the field of Internal Medicine. He received awards:"Meaningful Use Stage 1 Certification". Doctor Michael P. Bova, MD is a published physician. He has 39 papers published. The most current publication "Mutation of alpha B-crystallin: effects on chaperone-like activity." Doctor Michael P. Bova, MD is registered with Medicare.

Publications

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• Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors.
• Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain.
• Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors.
• Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
• Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
• Development of a Novel ?-Secretase Binding Assay Using the AlphaScreen Platform.
• Design and synthesis of Highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
• Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors.
• A Label-Free Approach to Identify Inhibitors of {alpha}4{beta}7- Mediated Cell Adhesion to MadCAM.
• Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
• The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.
• Subunit exchange, conformational stability, and chaperone-like function of the small heat shock protein 16.5 from Methanococcus jannaschii.
• Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease.
• Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target.
• Structure and function of the conserved domain in alphaA-crystallin. Site-directed spin labeling identifies a beta-strand located near a subunit interface.
• Acute and Chronic administration of cocaine produces hyperthermia in the rat.
• Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.
• Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-Di-o-tolylguanidine on body temperature in the rat: interactions wi...
• Lens alpha-crystallin: function and structure.
• Subunit exchange of alphaA-crystallin.
• Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.
• Subunit exchange of small heat shock proteins. Analysis of oligomer formation of alphaA-crystallin and Hsp27 by fluorescence resonance energy transfer and site-directe...
• Mutation of alpha B-crystallin: effects on chaperone-like activity.
• Lens alpha-crystallin: chaperone-like properties.
• Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies.
• Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's Disease-related toxicity in human neurons.
• Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer''s Disease.
• Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
• Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
• Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.
• N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
• Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1'' substituents.
• Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
• Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
• Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
• Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2'' substituents.
• Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
• Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's Disease.

Schools

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• Southern Illinois University School Of Medicine

• So Il University

• Southern Ill University

• Siu Affil Hospital

Procedures Preformed

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• Joint Injection

Conditions Treated

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• Anemia
• Anxiety
• Arthritis
• Asthma
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Doctors Specialties

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• Internal Medicine

Accepted Insurances

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• Assurant Health
• Blue Card PPO
• Blue Choice
• Blue Cross Blue Shield of Illinois PPO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• Open Access
• Commercial Insurance Company
• CoreSource
• Platinum PPO
• Coventry Health Care of Missouri
• First Health (Coventry Health Care) PPO
• Golden Rule
• HealthLink PPO
• Choice Care PPO
• Medicare MCR
• Medico
• MultiPlan PPO
• PHCS Network PPO
• NGS CoreSource
• Principal Life
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• United Healthcare

Awards

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• Meaningful Use Stage 1 Certification

Education

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• Southern Illinois University

Hospital

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• St. John's Hospital

Drug Facts

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NPI NUMBER		1861489510
NPPES Provider LastName		BOVA
NPPES Provider FirstName		MICHAEL
NPPES Provider ZIPCode		627048400
NPPES Provider State		IL
Specialty Description		Internal Medicine
Total Claim Count		10908.0
Distinct Opioid Count		10.0
Opioid Claim Count		807.0
Percent Opioid Claims		7.4

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1861489510
Last Name Of The Provider	BOVA
First Name Of The Provider	MICHAEL
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