Physician

Pathology

Michael Ittmann works in the field of Pathology. He went to medical school at NYU School of Medicine. Michael M. Ittmann is a published doctor and has 101 publications published. The lastest was: 'Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B.'

Publications

---

• A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation.
• Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.
• The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells.
• Interaction of the Androgen Receptor, ETV1, and PTEN Pathways in Mouse Prostate Varies with Pathological Stage and Predicts Cancer Progression.
• Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis.
• Stromal TGF-β signaling induces AR activation in prostate cancer.
• The Prostate Cancer TMPRSS2:ERG Fusion Synergizes with the Vitamin D Receptor (VDR) to Induce CYP24A1 Expression Limiting VDR Signaling.
• Recruitment of CD34(+) Fibroblasts in Tumor-Associated Reactive Stroma: The Reactive Microvasculature Hypothesis.
• The senescence-associated secretory phenotype promotes benign prostatic hyperplasia.
• T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo.
• FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma.
• Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin.
• Semaphorin 4F as a Critical Regulator of Neuroepithelial Interactions and a Biomarker of Aggressive Prostate Cancer.
• Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.
• Genes Upregulated in Prostate Cancer Reactive Stroma Promote Prostate Cancer Progression In Vivo.
• Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia.
• The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer.
• A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.
• HLA-restricted NY-ESO-1 peptide immunotherapy for metastatic castration resistant prostate cancer.
• Endocrine Fibroblast Growth Factor FGF19 Promotes Prostate Cancer Progression.
• Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.
• Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.
• COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.
• Highly Specific Targeting of the TMPRSS2/ERG Fusion Gene Using Liposomal Nanovectors.
• Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity.
• IRIS iQ200 workstation as a screen for performing urine culture.
• Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression.
• Common Structural and Epigenetic Changes in the Genome of Castration Resistant Prostate Cancer.
• GLIPR1 suppresses prostate cancer development by targeted oncoprotein destruction.
• GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding r...
• Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing.
• FGFR-4 Arg388 enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling.
• Detection of recurrent rearrangement breakpoints from copy number data.
• INPP4B: the New Kid on the PI3K Block.
• Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk.
• Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.
• Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens.
• SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
• Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer.
• Relaxin/RXFP1 signaling in prostate cancer progression.
• Cancer-related axonogenesis and neurogenesis in prostate cancer.
• Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt.
• Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death.
• Relaxin promotes prostate cancer progression.
• Hypoxic adipocytes pattern early heterotopic bone formation.
• Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurre...
• Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression.
• Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer...
• RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.
• Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate.
• Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer.
• Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model.
• The role of caveolin-1 in androgen insensitive prostate cancer.
• Impact of preimmunization on adenoviral vector expression and toxicity in a subcutaneous mouse cancer model.
• Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation.
• Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression.
• The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo.
• Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.
• Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.
• TGF-?1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.
• Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4.
• Dicer ablation impairs prostate stem cell activity and causes prostate atrophy.
• Global gene expression analysis of reactive stroma in prostate cancer.
• Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX.
• DNA methylation and aberrant expression of Sprouty1 in human prostate cancer.
• GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.
• Paths of FGFR-driven tumorigenesis.
• DNA methylation of the PITX2 gene promoter region is a strong independent prognostic marker of biochemical recurrence in patients with prostate cancer after radical pr...
• Genomic profiling of prostate cancers from African American men.
• Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression.
• Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.
• Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts.
• Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach.
• Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway.
• Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition.
• Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling.
• Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
• Oxygen tension directs chondrogenic differentiation of myelo-monocytic progenitors during endochondral bone formation.
• Age-related DNA methylation changes in normal human prostate tissues.
• The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase.
• Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma.
• Increased expression of the metastasis-associated gene Ehm2 in prostate cancer.
• Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer.
• A working group classification of focal prostate atrophy lesions.
• SRC-3 is required for prostate cancer cell proliferation and survival.
• PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer.
• Bystin in perineural invasion of prostate cancer.
• Mutation of the androgen receptor causes oncogenic transformation of the prostate.
• The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
• Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer.
• CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer.
• Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.
• Enhancement of both cellular and humoral responses to genetic immunization by co-administration of an antigen-expressing plasmid and a plasmid encoding the pro-apoptot...
• Inhibition of proliferation and survival of melanoma cells by adenoviral-mediated expression of dominant negative fibroblast growth factor receptor.
• FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia.
• Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia.
• The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.
• Growth and survival mechanisms associated with perineural invasion in prostate cancer.
• The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression.
• Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B.

Doctors Specialties

---

• Anatomic Pathology
• Pathology

Accepted Insurances

---

Education

---

• NYU School of Medicine
• Case Western Reserve University School of Medicine

Hospital

---

• Michael E. DeBakey Veterans Affairs Medical Center

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Clifford D. Sauls, MD This Doctor is OpenDoctor Recommended.
	Dr. Luan D. Truong, MD This Doctor is OpenDoctor Recommended.
	Dr. Rodolfo Laucirica, MD This Doctor is OpenDoctor Recommended.
	Dr. Sarah K. Hartman, MD This Doctor is OpenDoctor Recommended.
	Dr. Nour Sneige, MD This Doctor is OpenDoctor Recommended.
	Dr. Gregg A. Staerkel, MD This Doctor is OpenDoctor Recommended.
	Dr. Zainab A. Almatar, MD This Doctor is OpenDoctor Recommended.
	Dr. Jose A. Gomez, MD
	Dr. Susan L. Haley, MD
	Dr. Guohui Lu, MD This Doctor is OpenDoctor Recommended.
	Anupma Nayak, MB
	Dr. Diana Bell Matesoi, MD

---

Doctor Directory | TOS | twitter | FB | Angel | blog