Seldin Professor and Director, Pulmonary and Critical Care Medicine, Washington University School of Medicine
Pulmonology
Dr. Michael J. Holtzman, MD
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Michael Holtzman is an expert in the field of Pulmonology. He attended Northwestern University Feinberg School of Medicine. Northwestern University Feinberg School of Medicine is ranked 19/29 in Research/PrimaryCare. He has 2 awards "Member" and "Fellow". Michael J. Holtzman is a published doctor and has 101 publications published. The lastest was: 'Resistance to Fas-mediated T cell apoptosis in asthma.'
Publications
- IL13 activates autophagy to regulate secretion in airway epithelial cells.
- OSCAR Is a Receptor for Surfactant Protein D That Activates TNF-α Release from Human CCR2+ Inflammatory Monocytes.
- Myb permits multilineage airway epithelial cell differentiation.
- Linking Acute Infection to Chronic Lung Disease. The Role of IL-33-Expressing Epithelial Progenitor Cells.
- A novel mode of ISG15 mediated protection against influenza A virus and Sendai virus in mice.
- The role of airway epithelial cells and innate immune cells in chronic respiratory disease.
- Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
- The red journal at 25 years. Looking back and looking ahead.
- Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory d...
- Circulating TSLP associates with decreased wheezing in non-atopic preschool children: Data from the URECA birth cohort.
- Volatile-Sensing Functions for Pulmonary Neuroendocrine Cells.
- High-Throughput Screening Normalized to Biological Response: Application to Antiviral Drug Discovery.
- Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life.
- Molecular heterogeneity in the choroid plexus epithelium: the 22-member ?-protocadherin family is differentially expressed, apically localized, and implicated in CSF r...
- Alternatively activated macrophages and airway disease.
- Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb.
- Host epithelial-viral interactions as cause and cure for asthma.
- Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.
- Tracking cell lineage to rediscover (again) the switch from ciliated to mucous cells.
- Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts.
- Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma.
- Viral and host strategies to take advantage of the innate immune response.
- Alternatively activated macrophages as cause or effect in airway disease.
- Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
- Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.
- New immune pathways from chronic post-viral lung disease.
- Macrophage chitinase 1 stratifies chronic obstructive lung disease.
- Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
- Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma.
- Oxidative damage to nucleic acids in severe emphysema.
- The role of CLCA proteins in inflammatory airway disease.
- Immune pathways for translating viral infection into chronic airway disease.
- Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
- Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection.
- Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection.
- Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
- Controls for lung dendritic cell maturation and migration during respiratory viral infection.
- STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma.
- A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells.
- Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.
- Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells.
- Chemokine complexity: the case for CCL5.
- Immunogenetic programs for viral induction of mucous cell metaplasia.
- Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.
- Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.
- Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation.
- Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness.
- Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.
- Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense.
- CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.
- Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment.
- Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment.
- Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness.
- A centennial history of research on asthma pathogenesis.
- Defining and adjusting divergent host responses to viral infection.
- Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease.
- "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease.
- Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway.
- Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholip...
- Drug development for asthma.
- Transition, sunlight, and the art of journal maintenance.
- Apoptosis in the airways: another balancing act in the epithelial program.
- Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.
- Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture.
- Where are the gaps in asthma research? A counter-perspective.
- Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma.
- Viral induction of a chronic asthma phenotype and genetic segregation from the acute response.
- Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway.
- Determinants of outcome for patients admitted to a long-term ventilator unit.
- Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm.
- Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease.
- Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion.
- Regulation of T cell apoptosis.
- Interleukin 12 p40 production by barrier epithelial cells during airway inflammation.
- Cross-talk between interleukin 1beta (IL-1beta) and IL-6 signalling pathways: IL-1beta selectively inhibits IL-6-activated signal transducer and activator of transcrip...
- Perennial goals for the millennium.
- Could asthma be worsened by stimulating the T-helper type 1 immune response?
- Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization.
- Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
- Resistance to Fas-mediated T cell apoptosis in asthma.
- Direct suppression of Stat1 function during adenoviral infection.
- Matching scientific with societal interests: charges for the new editor.
- Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo.
- Control of epithelial immune-response genes and implications for airway immunity and inflammation.
- Targeted inhibition of interferon-gamma-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1.
- Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2.
- The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?
- Stat1 depends on transcriptional synergy with Sp1.
- Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
- A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells.
- Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.
- A molecular switch between lung development and cancer: is the tumor suppressor Rb turned on during bronchial epithelial cell differentiation and turned off in small c...
- Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the ...
- Does gene therapy call for "STAT" immunity and inflammation at the epithelial barrier?
- Prostaglandin H synthase and lipoxygenase gene families in the epithelial cell barrier.
- Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
- A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes V delta 1+ gamma delta T cell adherence and t...
- Selective differences in vascular endothelial- vs. airway epithelial-T cell adhesion mechanisms.
- Barbiturates depress vagal motor pathway to ferret trachea at ganglia.
- Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs.
Schools
Northwestern Center Feinberg School of Medicine
Duke Med Center
University Calif
Doctors Specialties
- Pulmonology
Accepted Insurances
Awards
- Member
- Fellow
Education
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Duke University Hospital -
Northwestern University Feinberg School of Medicine
Hospital
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Barnes-Jewish Hospital
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