Director, Long QT Syndrome/Genetic Heart Rhythm Clinic at Mayo Clinic
Pediatric Cardiology
Dr. Michael J. Ackerman, MD
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Dr. Michael J. Ackerman works in the field of Pediatric Cardiology. He studied medicine at Mayo Medical School. Mayo Medical School has a rank of 27 in research and a 42 in primary care He has 29 awards "America's Top Doctors", "Dean's Recognition Award", "Center for Individualized Medicine Award", "Department of Medicine Outstanding Investigator Award", "Elected Member", "Inductee", "Teacher of the Year", "Distinguished Service Award", "25th Young Investigator Award", "Medical School Continuing Medical Education Faculty of the Year", "Travel Award", "15th Annual Niland Lecturer", "Young Investigator Award (Section on Perinatal Pediatrics)", "Young Investigator Award Finalist", "Best Pediatric Poster Award", "Donald C. Balfour Research Award", "Clinical Fellow Research Award", "Outstanding Presentation Award", "Pediatric Resident Research Award", "Best Poster Award", "Molecular Medicine Award", "Distinguished Fellowship Award", "Medical Student Award", "Karis Award", "International TaeKwonDo Club of the Year", "Phi Beta Kappa", "Torrison Research Scholarship", "Regional TaeKwonDo Instructor of the Year" and "Fellow (FACC)". Michael Ackerman is a published physician. He has 96 papers published. The most current publication "Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes."
Publications
- Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes.
- Electromechanical window negativity in genotyped long-QT syndrome patients: relation to arrhythmia risk.
- Rationale and Objectives for ECG Screening in Infancy.
- Novel Timothy syndrome mutation leading to increase in CACNA1C window current.
- Beta-Blockers in the Treatment of Congenital Long QT Syndrome: Is One Beta-Blocker Superior to Another?
- Impact of Left Ventricular Hypertrophy on QT Prolongation and Associated Mortality.
- Heart-Rate-Corrected QT Interval Evolution in Premature Infants During the First Week of Life.
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
- Atypical atrioventricular nodal reentry tachycardia in a child with polyvalvular dysplasia.
- Etiologies of Sudden Cardiac Death in National Collegiate Athletic Association Athletes.
- Marked, transient, emotion-triggered QT accentuation in an adolescent female with type 1 long QT syndrome.
- Loss-of-function of the Voltage-gated Sodium Channel NaV1.5 (Channelopathies) in Patients with Irritable Bowel Syndrome.
- Distinguishing Hypertrophic Cardiomyopathy-Associated Mutations from Background Genetic Noise.
- Prevalence and spectrum of electroencephalogram-identified epileptiform activity among patients with long QT syndrome.
- Confirmation of Cause and Manner of Death Via a Comprehensive Cardiac Autopsy including Whole Exome Next-Generation Sequencing.
- QTc Interval Prolongation and Severe Apneas Associated With a Change in Infant Positioning.
- Surgical myectomy improves pulmonary hypertension in obstructive hypertrophic Cardiomyopathy.
- Sympathetic nerve activity and simulated diving in healthy humans.
- FGF12 is a candidate Brugada syndrome locus.
- Deformation patterns in genotyped patients with hypertrophic Cardiomyopathy.
- A KCNQ1 Mutation Contributes to the Concealed Type 1 Long QT Phenotype by Limiting the Kv7.1 Channel Conformational Changes Associated with PKA Phosphorylation.
- Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization.
- Stroke or Transient Ischemic Attack in Patients With Transvenous Pacemaker or Defibrillator and Echocardiographically Detected Patent Foramen Ovale.
- Uncompressed high-definition videoconferencing tools for telemedicine and distance learning.
- Junctophilin-2 is necessary for T-tubule maturation during mouse Heart development.
- Maternal mosaicism confounds the neonatal diagnosis of type 1 Timothy syndrome.
- Prognostic implications of mutation-specific QTc standard deviation in Congenital long QT syndrome.
- Safety of sports for athletes with implantable cardioverter-defibrillators: results of a prospective, multinational registry.
- Impact of Genetics on the Clinical Management of Channelopathies.
- Institution-wide QT alert system identifies patients with a high risk of mortality.
- Personalized medicine: genetic diagnosis for inherited cardiomyopathies/channelopathies.
- Prevention of sudden cardiac death with implantable cardioverter-defibrillators in children and adolescents with hypertrophic Cardiomyopathy.
- Malignant Bileaflet Mitral Valve Prolapse Syndrome in Patients with Otherwise Idiopathic Out of Hospital Cardiac Arrest.
- Risk of Death in Long-Term Follow-Up of Patients With Apical Hypertrophic Cardiomyopathy.
- Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations.
- Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A.
- Does Low-dose Droperidol Increase the Risk of Polymorphic Ventricular Tachycardia or Death in the Surgical Patient?
- Electrocardiographic interpretation in athletes: the 'Seattle criteria'.
- Normal electrocardiographic findings: recognising physiological adaptations in athletes.
- Abnormal electrocardiographic findings in athletes: recognising changes suggestive of Cardiomyopathy.
- Abnormal electrocardiographic findings in athletes: recognising changes suggestive of primary electrical Disease.
- Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes.
- Genetic testing in heritable cardiac arrhythmia syndromes: differentiating pathogenic mutations from background genetic noise.
- Three Principles for Determining the Relevancy of Store-and-Forward and Live Interactive Telemedicine: Reinterpreting Two Telemedicine Research Reviews and Other Resea...
- A KCNQ1 Mutation Causes a High Penetrance for Familial Atrial Fibrillation.
- Arrhythmias: Epinephrine test for sudden cardiac death-is it too early?
- Repeat long QT syndrome genetic testing of phenotype-positive cases: Prevalence and etiology of detection misses.
- Mechanism of Loss of Kv11.1 K+ Current in Mutant T421M-Kv11.1 Expressing Rat Ventricular Myocytes: Interaction of Trafficking and Gating.
- Return to play? Athletes with Congenital long QT syndrome.
- Outcome of septal myectomy for obstructive hypertrophic Cardiomyopathy in children and young adults.
- Ranolazine inhibits shear sensitivity of endogenous Na (+) current and spontaneous action potentials in HL-1 cells.
- Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death.
- TGF?-inducible early gene-1 (TIEG1) mutations in hypertrophic Cardiomyopathy.
- Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify Disease severity in patients with type 1 long QT syndrome in an allele-speci...
- Connexin43 Mutation Causes Heterogeneous Gap Junction Loss and Sudden Infant Death.
- A Novel Rare Variant in SCN1Bb Linked to Brugada Syndrome and SIDS by Combined Modulation of Nav1.5 and Kv4.3 Channel Currents.
- QTc Values Among Children and Adolescents Presenting to the Emergency Department.
- Congenital type 1 long QT syndrome unmasked by a highly caffeinated energy drink.
- Trigger-Specific Ion-channel Mechanisms, Risk Factors, and Response to Therapy in Type 1 Long QT Syndrome.
- Call for a Sudden Cardiac Death Registry: Should Reporting of Sudden Cardiac Death be Mandatory?
- Microvascular function is selectively impaired in patients with hypertrophic Cardiomyopathy and sarcomere myofilament gene mutations.
- Loss-of-Function Mutations in the KCNJ8-Encoded Kir6.1 KATP Channel and Sudden Infant Death Syndrome.
- Risk of Syncope in Family Members Who Are Genotype Negative for a Family-Associated Long QT Syndrome Mutation.
- HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies This document was developed as a partnership between t...
- Meaningful images.
- Anesthetic management of patients with Brugada syndrome: a case series and literature review.
- Left Ventricular Noncompaction Syndrome Masquerading or Misdiagnosed as Congenital Long QT Syndrome: Remember QT Prolongation Does Not Equal Long QT Syndrome.
- Distinguishing arrhythmogenic right ventricular Cardiomyopathy/dysplasia-associated mutations from background genetic noise.
- Risk of Recurrent Cardiac Events After Onset of Menopause in Women With Congenital Long-QT Syndrome Types 1 and 2.
- The Diagnostic Utility of Recovery Phase QTc During Treadmill Exercise Stress Testing in the Evaluation of Long QT Syndrome.
- The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current.
- Electrocardiographic changes and Arrhythmias following percutaneous atrial septal defect and patent foramen ovale device closure.
- Electrocardiographic and oximetric changes during partial complex and generalized seizures.
- Holter Monitoring in the Evaluation of Congenital Long QT Syndrome.
- Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.
- Slow QT interval adaptation to Heart rate changes in normal ambulatory subjects.
- Left Cardiac Sympathetic Denervation in a Pediatric Patient with Hypertrophic Cardiomyopathy and Recurrent Ventricular Fibrillation.
- Mutation and Gender Specific Risk in Type-2 Long QT Syndrome: Implications for Risk Stratification for Life-Threatening Cardiac Events in Patients with Long QT Syndrome.
- Genotype-Specific QT Correction for Heart Rate and the Risk of Life Threatening Cardiac Events in Adolescents with the Congenital Long-QT Syndrome.
- Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice.
- Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
- Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
- Tagging the EMR.
- Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.
- Clinical spectrum in a family with tropomyosin-mediated hypertrophic Cardiomyopathy and sudden death in childhood.
- Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals.
- R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial Atrial fibrillation.
- PLN-encoded phospholamban mutation in a large cohort of hypertrophic Cardiomyopathy cases: summary of the literature and implications for genetic testing.
- Mutation type is not clinically useful in predicting prognosis in hypertrophic Cardiomyopathy.
- The prevalence and diagnostic/prognostic utility of sinus arrhythmia in the evaluation of Congenital long QT syndrome.
- Trigger-specific risk factors and response to therapy in long QT syndrome type 2.
- A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of Cardiomyopathy.
- Exercise extreme caution when calling rare genetic variants novel arrhythmia syndrome susceptibility mutations.
- Role of family history of sudden death in risk stratification and prevention of sudden death with implantable defibrillators in hypertrophic Cardiomyopathy.
- Implantable cardioverter defibrillator therapy for Congenital long QT syndrome: a single-center experience.
Schools
Mayo Medical School
Mayo Grad School MedMayo Fndn
Conditions Treated
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
- Congenital Heart Disease
- Hypertension
- View All
Doctors Specialties
- Pediatric Cardiology
Accepted Insurances
Awards
- America's Top Doctors
- Dean's Recognition Award
- Center for Individualized Medicine Award
- Department of Medicine Outstanding Investigator Award
- Elected Member
- Inductee
- Teacher of the Year
- Distinguished Service Award
- 25th Young Investigator Award
- Medical School Continuing Medical Education Faculty of the Year
- Travel Award
- 15th Annual Niland Lecturer
- Young Investigator Award (Section on Perinatal Pediatrics)
- Young Investigator Award Finalist
- Best Pediatric Poster Award
- Donald C. Balfour Research Award
- Clinical Fellow Research Award
- Outstanding Presentation Award
- Pediatric Resident Research Award
- Best Poster Award
- Molecular Medicine Award
- Distinguished Fellowship Award
- Medical Student Award
- Karis Award
- International TaeKwonDo Club of the Year
- Phi Beta Kappa
- Torrison Research Scholarship
- Regional TaeKwonDo Instructor of the Year
- Fellow (FACC)
Education
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Mayo School of Graduate Medical Education -
Mayo Medical School
Hospital
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Mayo Clinic - Rochester, Minnesota
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